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Immunohistological study of glandular development in the human infant larynx

Research Project

Project/Area Number 11671716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKurume University School of Medicine

Principal Investigator

NAKASHIMA Tadashi  Kurume University, Department of Otolaryngology, Professor, 医学部, 教授 (70117183)

Co-Investigator(Kenkyū-buntansha) UMENO Hirohito  Kurume University, Department of Otolaryngology, Assistant Professor, 医学部, 講師 (40203583)
HIBI Seishi  Kurume University, Department of Otolaryngology, Assistant Professor, 医学部, 講師 (40173190)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsinfant larynx / development / total development score / glandular acini / subglottis / supraglottis / 喉頭 / 小児 / 局所生体防御能 / 上気道
Research Abstract

To elucidate the development of the mucosal defense system and its relation to the pathogenesis of diseases in the human larynx, we directed our attention to the changes in the laryngeal structures at the level of subglottic larynx of human infants who died within two years after birth. By making a transverse section at the level of the cricoid cartilage, the area as well as the diameter of each subglottic structure were both examined. A transverse section at the level of the supralottis was also examined at the level of the apex of the arytenoid cartilage. The microscopic view of each plane was transported to the image analyzing system and then the area of the mucosa as well as the glandular acini in the mucosa were both estimated. In this study, the results were analyzed not only by their age at death but also based on the total development score(TDS)which was estimated by adding the age at birth and the gestational period.
The areas of the whole structure, cricoid ring, subglottic mu … More cosa and inner cavity(available area)increased in close correlation with the TDS.In contrast to the increased iameter of the inner cavity, the thickness of the mucosa was almost at the same size. In order to predict the actual development of the local immune function due to the presence of the mucosal glandular system, we investigated the ratio of the area occupied by the glands. The average area of the mucosa or glandular acinic at the level of the false vocal cord was almost three times larger than that of the subglottis. At both levels, the area occupied by the glands increased according to the age at death and became more evident according to the total development score(TDS). However, there were no significant differences during the period of endotracheal intubation. These results indicate the stability of the subglottic airway with advancing age in the human infant larynx. It was also suggested that the glandular structure at the level of subglottic or supraglottic larynx in human infants develops constantly and equally after the birth. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Minoru Hirano: "Fibroblasts in human vocal fold mucosa"Acta Otolaryngol(Stockh). 119. 271-276 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato: "Electron microscopic and immunohistochemical investigation of Reinke's edema"Ann Otol Rhinol Laryngo. 108. 1682-1692 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato: "Laser arytenoidectomy for bilateral median vocal fold fixation."Laryngoscope. 111. 168-171 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 梅野 博仁: "声帯粘膜の細胞外マトリックスの加齢的変化"喉頭. 12. 69-73 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirohito Umeno: "Management of impaired vocal fold movement during sleep in a patient with Shy-Drager syndrome."Am J Otolaryngol . 21. 344-348 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato : "Ultrastructure of the vocal process of the arytenoid cartilage"Ann Otol Rhinol Laryngo. 109. 650-653 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中島 格: "CLIENT 21 No.14喉頭"病理組織検査. 8 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minoru Hirano, Kiminori Sato, Tadashi Nakashima: "Fibroblasts in human vocal fold mucosa."Acta Otolaryngol(Stockh). 119. 271-276 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato, Minoru Hirano, Tadashi Nakashima: "Electron microscopic and immunohistochemical investigation of Reinke's edema."Ann Otol Rhinol Laryngol. 108. 1682-1672 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirohito Umeno, Yoshihisa Ueda, Kazunori Mori, Keiichi Chijiwa, Tadashi Nakashima, Nasser M.Kotby: "Management of impaired vocal fold movement during sleep in a patient with Shy-Drager syndrome."Am J Otolaryngol. 21. 34-348 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato, Minoru Hirano, Tadashi Nakashima: "Ultrastructure of the vocal process of the arytenoid cartilage"Ann Otol Rhinol Laryngol. 109. 650-653 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minoru Hirano, Kiminori Sato, Tadashi Nakashima: "Fibroblasts in geriatric vocal fold mucosa."Acta Otolaryngol. 120. 336-340 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shun-ichi Yonekawa, Hiroyuki Fukunaga, Hirohito Umeno, Kazunori Mori, Tadashi Nakashima: "Subglottic airway becomes stable with age in the human infant larynx"Acta Otolaryngol. 120. 444-449 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kiminori Sato: "Laser arytenoidectomy for bilateral median vocal fold fixatio"Laryngoscope. 111. 168-171 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 梅野博仁: "声帯粘膜の細胞外マトリックスの加齢的変化"喉頭. 12. 69-73 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirohito Umeno: "Management of impaired vocal fold movement during sleep in patient with Shy-Drager syndrome."Am J Otolaryngol. 21. 34-38 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kiminori Sato: "Ultrastructure of the vocal process of the arytenoid cartilag"Ann Otol Rhinol Laryngology. 109. 650-653 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shun-ichi Yonekawa: "Subglottic airway becomes stable with age in the human infar larynx"Acta Otolaryngol. 120. 444-449 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉田義一: "嚥下咽頭期に関わる咽喉頭筋:支配運動ニューロンと筋線維タイプ"口咽科. 12. 269-279 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中島格: "CLIENT21No.14喉頭"病理組織検査. 8 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 香田 千絵子: "機能性発声障害の臨床的検討"音声言語医学. 40. 1-7 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Minoru Hirano: "Fibroblasts in human vocal fold mucosa"Acta Otolaryngol (Stockh). 119. 271-276 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中島 格: "早期喉頭癌の直達鏡下レーザー手術のコツ"耳鼻臨床. 92. 916-917 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 千々和圭一: "腫瘍進展部位からみた声門上癌の治療法と治療成績"日気食会報. 50. 463-469 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kiminori Sato: "Electron microscopic and immunohistochemical investigatio of Reinke's edema"Ann Otol Rhinol Laryngol. 108. 1068-1072 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森 一功: "T1,T2喉頭癌の機能保存治療"喉頭. 11. 47-52 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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