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Molecurar immunological study of VKH disease

Research Project

Project/Area Number 11671722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionAKITA UNIVERSITY

Principal Investigator

YAMAKI Kunihiko  Akita University, School of Medicine, associate proffessor, 医学部, 助教授 (20125751)

Co-Investigator(Kenkyū-buntansha) KONNO Seiki  Akita University, School of Medicine, Research Associate, 医学部, 助手 (00312710)
SAKURAGI Shozo  Akita University, School of Medicine, Proffesor, 医学部, 教授 (80006767)
亀谷 修平  秋田大学, 医学部, 助手 (30302269)
近藤 功  秋田大学, 医学部, 助手 (50234927)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsTyrosinase / Transgenic rats / MHC / Expression
Research Abstract

We have reported that tyrosinase family protein can induce autoimmune disease similar to Vogt-Koyanagi Harada disease (VKH). The lymphocytes from PBMC with VKH disease patients proliferate against tyrosinase family proteins. These results suggest that tyrosinase family proteins are antigens specific to VKH.
In this project, we further confirmed these results and studied the immune reactions involved in VKH.To clarify the development and differentiation of autoreactive T cells in VKH, we are now making the transgenic Lewis rats expressing tyrosinase. Lewis rats lacks the tyrosinase, but are sensitive to the various kind of autoimmune disease. The Lewis rats that express tyrosinase in different organs and periods will be effective to study the central and peripheral tolerance against autoantigens.
We are planing to make the transgenic rats that will express tyrosinase under the promoter of arrestin for retina specific expression, β-actin for ubiquitous expression and tyrosinase for melanocyte. We are now making the siblings of the rats bearing the transgene.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] KUNIHIKO YAMAKI: "Ocular and Extraocular Inflammation Induced by Immunization of Tyrosinase Related Protein land 2 Lewis Rats"EXPERIMENTAL EYE RESEARCH. 71. 361-369 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] KUNIHIKO YAMAKI: "Tyrosinase Family Proteins Are Antigens Specific to Vogt-Koyanagi-Harada Disease"The Journal of Immunology. 165. 7323-7329 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kunihiko Yamaki, Isao Kondo, Hideo Nakamura, Mika Miyano, Seiki Konnno, and Synozo Sakuragi.: "Ocular and Extraocular Inflammation Induced by Immunization of Tyrosinase Related Protein 1 and 2 in Lewis Rats."Experimental Eye Reseach. 71. 361-369 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kunihiko Yamaki, Kiyoko Gocho, KOichi Hayakawa, Isao Kondo, and Shozo Sakuragi.: "Tyrosinase Family Proteins Are Antigens Specific to Vogt-Koyanagi-Harada Disease."The Journal of Immunology. 165. 7323-7329 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] KUNIHIKO YAMAKI: "Ocular and Extraocular Inflammation Induced by Immunization of Tyrosinase Related Protein 1 and 2 in Lewis Rats"EXPERIMENTAL EYE RESEARCH. 71. 361-369 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] KUNIHIKO YAMAKI: "Tyrosinase Family Proteins Are Antigens Specific to Vogt-Koyanagi-Harada Disease"The Journal of Immunology. 165. 7323-7329 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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