| Project/Area Number |
11671792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | KAWASAKI MEDICAL SCHOOL |
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Principal Investigator |
MORIGUCHI Takahiko KAWASAKI MEDICAL SCHOOL, MEDICINE, PROFESSOR, 医学部, 教授 (10111816)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasuhiro KAWASAKI MEDICAL SCHOOL, MEDICINE, RESIDENT, 医学部, 助手
浜崎 多美子 川崎医科大学, 医学部, 助手 (70299212)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Keloid / fibroblasts / growth factors / collagenase / 創傷治癒 / 細胞増殖 / Fibroblasts / TGF-β / TNF-α / コラーゲン代謝 / 相互作用 |
|---|
| Research Abstract |
Regarding wound repair, there are important but as yet unknown factors involved in the regulation of fibroblast function in the formation of hypertrophic scars and keloids. If these factors could be clarified, new therapies for keloids could be developed.
Recently, some researchers have reported that growth factors and cytokines possess some abilities to control hypertrophic scar and keloid formation.
The purpose of this study was to investigate whether the collagenase activity in human keloid fibroblasts is stimulated by two kinds of growth factors, TNF -α and TGF-β. Increased levels of collagenase activity were found in human keloid fibroblasts following exposure to TNF - α. A decreased level of collagenase activity was found in human keloid fibroblasts following exposure to both TNF - α and TGF- β. These results indicate that TGF- β can inhibit collagenase activity in human keloid fibroblasts stimulated by TNF - α, suggesting that growth factors and cytokines may play a therapeutic role in keloid formation.
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