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Relationship between expression of E1AF and histological malignancies of oral squamous cell carcinoma

Research Project

Project/Area Number 11671863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

ONO Mitsunobu  Hokkaido Univ., Graduate School of Dental Medicine, Inst., 大学院・歯学研究科, 助手 (50281829)

Co-Investigator(Kenkyū-buntansha) YASUDA Motoaki  Hokkaido Univ., Graduate School of Dental Medicine, Inst., 大学院・歯学研究科, 助手 (90239765)
HIGASHINO Fumihiro  Hokkaido Univ., Graduate School of Dental Medicine, Inst., 大学院・歯学研究科, 助手 (50301891)
SHINDOH Masanobu  Hokkaido Univ., Graduate School of Dental Medicine, Associate Prof., 大学院・歯学研究科, 助教授 (20162802)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsets transcription factor E1AF / Oral squamous cell carcinoma / MMP / VEGF / Lymph node metastasis
Research Abstract

E1AF is an ets-oncogene family transcription factor. Previous reports have noted that E1AF can up-regulate transcription from multiple matrix metalloprotease (MMP) genes that confers invasive phenotype on human cancer cells. We have reported that the close correlation of E1AF expression and cancer cell malignancy by in vitro studies. This Implies that E1AF expression may contribute to predict the prognosis of patients with oral squamous cell carcinoma. In the present study, we have investigated the expression level of E1AF, MT1-MMP as well as vascular endothelial growth factor (VEGF) and evaluated the correlation to the metastatic potential in oral cancer patients.
Thirty-two cases of pathologically diagnosed as squamous cell carcinoma were investigated. All cases were T1 or T2 in the clinical staging. Lymph node metastasis was identified in 18 of the 32 cases examined. E1AF was positive 11 of the 32 cases, and lymph node metastasis was identified in 7 of the 11 E1AF positive cases (63.3 %). Five of the 32 cases were MT1-MMP positive, and all 5 cases were among the E1AF positive case. Four of the 5 MT1-MMP positive cases showed lymph node metastasis. VEGF was positive in 11 cases and lymph node metastasis was observed in 10 of the 11 VEGF positive cases (90.9%) that was statistically significant. There were 17 cases of which E1AF or VEGF was positive, and lymph node metastasis was identified in 12 of the 17 cases (70.6%). There were 15 cases in which E1AF and VEGF both were negative, and lymph node metastasis was identified in only 6 of these 15 cases (40%). These results indicate that the expression of E1AF and VEGF are important factors to predict the invasive and metastatic potential of oral squamous cell carcinomas.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 松沢祐介: "口腔扁平上皮がんの予後因子の検討-E1AF・MT1-MMP・VEGFの発現と転移との関連-"北海道歯学雑誌. 21. 285-293 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shindon M.: "BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma"Oral Oncal.. 36. 444-449 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hanzawa M.: "Hepatocyto growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes."Carcinogenesis. 21. 1079-1085 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 堀向弘眞: "肝細胞増殖因子(HGF)刺激における口腔扁平上皮がんの浸潤性におよぼすetsがん遺伝子群転写因子E1AFの役割"北海道歯学雑誌. 20. 167-175 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Horimukai H.: "The role of E1AF, an ets-oncogene family transcription factor, in hepatocyte growth factor (HGF) stimulation of oral squamous cell carcinoma cell invasion."Hokkaido J.Dent.Sci.. 20. 167-175 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shindoh, M., Adachi, M., Higashino, F., Yasuda, M., Hida, K., Ono, M., Nishioka, K., Takayama, S., Reed, J.C., Imai, K., Totsuka, Y., Kohgo, T.: "BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma."Oral Oncol. 36 (5). 444-449 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hanzawa, M., Shindoh, M., Higashino, F., Yasuda, M., Ono, M., Hida, K, Kohgo, T., Nakamura, M., Notani, K., Totsuka, Y., Yoshida, K., Fujinaga, K.: "Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma (SCC) cell invasion by activating matrix metalloproteinase genes."Carcinogenesis. 21 (6). 1079-1085 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsuzawa Y.: "Expression of E1AF, MT1-MMP, and VEGF as predictive factors for the metastasis of oral squamous cell carcinomas."Hokkaido J.Dent.Sci.. 21. 285-293 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary

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Published: 1999-04-01   Modified: 2016-04-21  

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