| Project/Area Number |
11671867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUJITA Minoru Hiroshima University, Dental School, Associate Professor, 歯学部, 助教授 (90116658)
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| Co-Investigator(Kenkyū-buntansha) |
HIROKAWA Yutaka Hiroshima University, Midical School, Associate Professor, 医学部, 助教授 (40116653)
NAITO Kumiko Hiroshima University, Dental School, Research Associate, 歯学部, 助手 (10155632)
赤木 由紀夫 広島大学, 医学部・附属病院, 助手 (40222509)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | RADIATION THERAPY / HYPERFRACTIONATION / ORAL CANCER / CHEMOTHERAPY / LATE COMPLICATION |
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| Research Abstract |
Eighty two patients with previously untreated and biopsy-proven squamous cell carcinoma of the oral cavity were treated by hyperfractionated radiotherapy(HF) with chemotherapy to improve treatment results of radiotherapy. Two-year survival rates of T1 to 4 were 80.4%, 65.5%, 32.7%, and 5.8%, respectively. There was not any findings which improved survival rates by HP alone. However, combined chemotherapy seemed to improve local control rates than HF alone treatment. A higher local control rate was obtained in the patients with lower stages of tumors, and it was considered in the standpoint of organ preservation that a smaller size of buccal carcinoma should be an indication for HF combined with chemotherapy.The results showed followings ; l)The total dose of 80Gy or more was tolerable to patients in the HF alone using a fraction size of 1.2 or 1.4Gy, and 70-74Gy in the HF combined with chemotherapy. 2)Smaller tumors were good candidates for HF with or without chemotherapy, but in larger tumors the goal of HF should be down-staging for a curative operation. 3)Both local and regional controls influenced the survival. 4)Acute reactions in HF alone were torelable to patients, but those in the combined treatment often needed a split of 1-2 weeks. 5)The severest late complication was the mandibular bone necrosis. It was found about 1.5 to 2 years after the treatment. It might be most important to exclude the mandible from an irradiated field as much as possible. This would be accomplished with a computer-simulation system which provide careful treatment planning. Urgent treatment of dental diseases which might be a source of infection should be advisable before radiotherapy. Intensive dental care was necessary not only before radiotherapy but also during and after it. The improvement of this complication should be a breakthrough for further application of HF with and without chemotherapy to oral cancers.
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