| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Research Abstract |
The stimulatory effects of fructooligosaccharides (FOS), increase intestinal calcium absorption, calcium balance and bone mineral density in rats. It has been speculated that this effect involves the production of short-chain fatty acids (SCFAs) in the large intestine, resulting from fermentation, since SCFAs stimulate the proliferation of epithelium cells in the intestine and reduce luminal pH.The enhanced calcium absorption produced by FOS-feeding might enhance bone volume. Mean while, gastrectomy-evoked osteopenia has been well known in human and animals. We present that enhanced mineral absorption due to FOS consumption reflects on bone in intact and gastrectomized rats. The intact rats fed control or 5% FOS-containing diet for 2 weeks (Exp. 1). Either sham-operated or gastrectomized rats fed control diet or 7.5% FOS-containing diet for 5 weeks (Exp. 2). Four weeks after sham-operation or gastrectomy, each rat fed control diet or 7.5% FOS-containing diet for 6 weeks (Exp. 3). After dietary treatments, either femur, tibia or mandibula was removed to examine bone volume or mineral density. Trabecular bone volume in the femoral metaphysis increased, in addition, enhanced mineral concentrations (Ca and Mg) were observed in the metaphysis, diaphysis and neck in the Exp. 1. Both cortical and trabecular bone in the femoral metaphysis and mandibula were markedly decreased in gastrectomized rats, meanwhile, FOS consumption completely prevented the femoral bone loss in the Exp. 2. FOS consumption partially improved the bone loss following gastrectomy in the Exp. 3. These results suggest that FOS consumption, physiologically or pathologically, induces a beneficial effect on bone. If similar effect in humans, treatment with FOS might help improve bone volume and mineral concentrations in various osteopenias.
|
