| Project/Area Number |
11671884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Nihon University |
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Principal Investigator |
AKIRA Fujii Dentistry at Matsudo, Pharmacology, Professor, 松戸歯学部, 教授 (70102564)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Yoshiaki Dentistry at Matsudo, Oral Surgery 2, Associate Professor, 松戸歯学部, 助教授 (10147720)
MATSUMOTO Hiroko Dentistry at Matsudo, Pharmacology, Research Assistant, 松戸歯学部, 助手 (50221594)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Osteoporosis / Mandible / pQCT / Rat / BMD / BMC / Femur / Trabecular bone |
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| Research Abstract |
The change of mandible during the development of osteoporosis is not studied extensively. The present investigation was undertaken to clarify the distinction between mandible and femtur in experimental osteoporosis rats and the possibility of new medication. Experimental osteoporosis in aged female rats (n=40) were prepared after ovariectomy (OVX) and maintained on refined calcium controlled (0.01% Ca) semisynthetic diet. Sham-operated group (n=20), intact control group (n=20), and the organic germanium compound, poly-trans (2-carboxy-ethyl) germaniumsesquioxide (Ge-132), -treated group (n=20) were used in the present study. The osteoporosis was developed in femur at 3 months after the initiation of the experiment. Mandible was extracted and subjected to bone mineral density (BMD) and bone mineral content (BMC) analyses using peripheral quantitative computed tomography (pQCT) Bone Scanner (XCT Research SA, Stratec Medizintechnic GmbH, Germany). The bone absorption of trabecular bone underneath the molar was found in rat mandible but not in cortical bone. Ge-132 gave significantly higher BMD of trabecular bone under the first molar. This indicates that the osteoporosis might get the fragility of alveolar bone and the depression of articulation, but treatment with Ge-132 on osteoporosis rats might prevent partially the bone absorption in mandible.
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