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Study of the effects of bisphenol A in the dental pulp tissue

Research Project

Project/Area Number 11671901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionMeikai university

Principal Investigator

KATAYAMA Tadashi  Mikai unversity, School of Dentsitry, Professor, 歯学部, 教授 (10105596)

Co-Investigator(Kenkyū-buntansha) YOKOSE Satoshi  Mikai Unversity, school of Dentisry, Assistant Professor, 歯学部, 助教授 (90245803)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsBisphenol A / Dental pulp tissue / HPLC / Mouse / OVXラット / エストロゲン / in vivo
Research Abstract

In order to examine the amount of bisphenol A (BPA) taken in the dental pulp tissues of mouse after peritoneal injection, we performed the HPLC analysis in the homogenized dental pulp tissues. The eight weeks old male mice were peritoneally injected BPA (100 μg/g body weight), and the dental pulp tissues were extracted from lower incisors after half and one hour of the injection, respectively. Then serums were also collected to analyze the amount of BPA.
The BPA levels of the dental pulp tissues indicated 100μg/g after half hour of the injection, and the levels were kept for one hour after the injection. On the other hand, serum levers of BPA reached to 1μg/μl after half hour of the injection and the levels were kept for one hour after the injection.
These results suggest that BPA is taken in the dental pulp tissue throughout the blood system and may be accumulated in the dental pulp tissue.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 菅原正之,横瀬敏志: "ヒト歯髄細胞における副甲状腺ホルモンの影響"日本歯科保存学雑誌. 44(1). 132-139 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 門倉弘志,横瀬敏志 他: "マウス下顎切歯におけるPTH/PTHrP receptor mRNAの発現"日本歯科保存学雑誌. 43(2). 572-577 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Sugawara and S.Yokose: "In vitro effect of parathyroid hormon in human dental pulp cells."The Japanese J.Conservative Dentistry. 44(1). 132-139 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kadokura, S.Yokose. et al.: "Demonstration of mRNA expression of PTH/PTHrP receptor in mouse mandibular incisor."The Japanese J.Conservative Dentistry. 43(2). 572-577 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 菅原正之,横瀬敏志: "ヒト歯髄細胞における副甲状腺ホルモンの影響"日本歯科保存学雑誌. 44(1). 132-139 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 門倉弘志,横瀬敏志 他: "マウス下顎切歯におけるPTH/PTHnP receptor mRNAの発現"日本歯科保存学雑誌. 43(2). 572-577 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 横瀬 敏志 他: "歯髄培養細胞におけるHomeobox遺伝子発現に及ぼすE_2の影響"日本歯科保存学会雑誌. 42(秋季号). 63-63 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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