| Project/Area Number |
11671931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
IRIE Masao Okayama University, School of Dentistry, Assistant Professor, 歯学部, 助手 (90105594)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Kunio Okayama University, School of Dentistry, Associate Professor, 歯学部, 助教授 (90202952)
SUZUKI Kazuomi Okayama University, School of Dentistry, Professor, 歯学部, 教授 (30050058)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | GBR / GTR / barrier membrane / Bone formation / Bone regeneration / alginate / Sodium alginate / Sodium choloride |
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| Research Abstract |
The aim of this study is to evaluate the usefulness of alginate membrane that can be formed immediately upon the reaction of sodium alginate and sodium chloride as an self setting barrier membrane of GBR.
We found alginate membrane was formed on the surface of bone defect without making clearance when the bone defect was filled with sodium alginate aqueous solution followed by dropping sodium chloride aqueous solution. When the tibiae of rats where GBR was made was taken out from the experimental animals 2, 4 and 8 weeks after surgery, we found bone was regenerated in the experimental group using 3% sodium alginate aqueous solution and 3% sodium chloride aqueous solution.
In the case of control group which bone defect was made and applied no GBR, bone defect was filled with connective tissue. The results cleary demonstrated that alginate membrane is useful as barrier membrane of GBR.
However, we found new bone was deformed when alginate membrane was made with using 10% sodium alginate aqueous solution and 3% sodium chloride aqueous solution, indicating that condition to prepare alginate membrane is important for the better bone regeneration. Also, we found poor bone formation on the skin site of bone defect when alginate membrane was prepared in advance and applied to the bone defect.
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