| Project/Area Number |
11671970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
INOUE Nobuo Hokkaido Univ., Grad.School of Dentistry, Prof., 大学院・歯学研究科, 教授 (20091415)
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| Co-Investigator(Kenkyū-buntansha) |
MINOWA Kazuyuki Hokkaido Univ., Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (30209845)
YAMAGUCHI Taihiko Hokkaido Univ., Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (90200617)
TOTSUKA Yasunori Hokkaido Univ., Grad.School of Dentistry, Prof., 大学院・歯学研究科, 教授 (00109456)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | blood flow volume / masticatory muscles / energy metabolism / 31P-MRS |
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| Research Abstract |
The purpose of this study was to clarify the the influences of regional tissue blood flow volume (RTVF volume) on energy metabolism in deep and superficial part of masseter muscle (Mm)
1. Establishment of 31P-Chemical Shift Imaging (CSI) for human Mm.
We have succeeded in analyzing energy metabolism in both deep and superficial part of Mm. It has become clear that the superficial part of Mm contains more phosphocreatine (PCr) than deep part. This result suggests that deep and superficial part of Mm need to be measured separately in analyzing energy metabolism.
2. Establishment of analyzing methods of RTVF volume.
A three wavelength spectrophotometric method were used. As the parameters of RTVF volume, total hemoglobin (Hb) volume, and ratio and period of change in Hb were selected. It was demonstrated that RTVF volume in Mm changes as head and/or upper half of body lean, and that we need to keep head and body position stable.
3. Establishment of condition for exercise task.
Among several condition for exercise task such as maximal clenching, gum chewing and so on, 10 kgf clenching for 20 sec. was considered to be adequate.
4. Measurements in healthy people and patients with temporomandibular disorders (TMD).
As for the energy metabolism, PCr in Mm of TMD patients was lower than that of healthy people. In other words, it was suggested that energy level of Mm in TMD patients was lower than that of healthy people. However, we could not obtain obvious conclusion concerning RTVF volume because of wide variation of the data. Therefore, to diminish the influence of the wide variation and to confirm the relation between energy metabolism and RTVF volume, we need to gather more data in further studies by using the analyzing methods established in this study.
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