| Project/Area Number |
11672010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
ICHINOHE Tatsuya TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY,PROFESSOR, 歯学部, 教授 (40184626)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Yuzuru TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, PROFESSOR, 歯学部, 教授 (00085747)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2002: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2001: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2000: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Rat / Rabbit / Noxious stimulation / Hemodynamic response / Hypertension / Trigeiainal nerve |
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| Research Abstract |
In rabbits, systolic blood pressure (SBP) showedbiphagic (depressor followedby presjsor) responses following electrical stimulation of the mental nerve. Depressor response, known as the trigeminal depressor response, wasprominent after low frequency stimulations. Fentanyl inhibited depressor response, whereas clonidine, neostigmine and L-phenylisopropyladenosine inhibited pressor response. At t|ie sane time, clonidine and L-phenylisopropyladenosine produced a dose-dependent SBP reduction. In contrast, SBP mainly showed pressor responses following electrical stimulation of the mentalnerve in rats. Although fentanyl revealed no effects on SBP change, clonidine, as in the rabbit experiments, inhibited pressor response along witha dose-dependent SBP reduction.
Electrical stimulation of the mental nerve for more than 30 sec produced sustained SBP elevation.Fentanyl and clonidine may modulate these SBP responses.
These results suggest that appropriate combinations of these agents that act at different siteof the nociceptive mechanisms may result in safe and effective total intravenous anesthesi for oral and maxillofacial surgery.
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