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EFFECTS OF FINE-GRAINED DIETS AND TOOTH ABSENCE ON THE GROWTH, AGING AND LIFE SPAN IN SAM P-1 MICE

Research Project

Project/Area Number 11672069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 矯正・小児・社会系歯学
Research InstitutionASAHI UNIVERSITY

Principal Investigator

IIUMA Mitsuo  ASAHI UNIVERSITY DEPARTMENT, TITLE OF POSITION: PEDLATRIC DENTISTRY, 歯学部・小児歯科, 助教授 (70184364)

Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsSAM Mouse / Aging / Soft Food / Loss of teeth / Life Span / 活動周期 / 歯の喪失
Research Abstract

The purpose of this study was to investigate the effects of tooth absence and powdered food on general growth, progression of aging and longevity
Ninety-three senescence accelerated mice (SAM P-Ita) were employed in the study. Mice displayed signs characteristic of early stage physiological aging and exhibited approximately one year of longevity. Animals were partitioned into five experimental groups consisting of the Control group (pellet food from five weeks after birth, no extraction), the Powdered group (powdered food from five weeks after birth, no extraction), the Upper / lower molar extraction group (pellet food, upper and lower all molar extraction at five weeks after birth) and the Upper molar extraction (pellet food, upper all molar extraction) and Lower molar extraction group (pellet food, lowerall molar extraction). Body weight, food consumption, senescence grading score (based on the conventions proposed by Council for SAM Research), locomotor activity over 24 hours, amiloidosis of tongue and life span were measured. Student's t-test was utilized for statistical analysis
No differences in body weight and food consumption were observed between groups Senescence grading scores and amiloidosis from 20 weeks after birth were the highest among all groups. Those of control group were the lowest. Activity and survival rate of the powdered group were the lowest among all groups. Those of control group were the highest. No difference were found among three extraction groups. These findings suggest powdered food and molar absence affects senescence and life span

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 鈴木康秀, 飯沼光生, 安井清子, 高田真希, 峯田淑子, 田村康夫: "歯の喪失が老化促進マウス(SAMP1)の成長・老化に及ぼす影響"小児歯科学雑誌. 40巻1号. 103-113 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 平良梨津子, 飯沼光生, 鈴木康秀, 田村康夫: "粉末食飼育が老化促進マウス(SAMP1)の成長・老化に及ぼす影響"小児歯科学雑誌. 37巻4号. 798-809 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] RITSUKO TAIRA, MITSUO IINUMA, YASUHIDE SUZUKI and YASUO TAMURA: "EFFECTS OF FINE-GRAINED DIETS ON GROWTH AND AGING IN SENESCENCE ACCELERATED MICE"JPN. J. PED. DENT. 37(4). 798-809 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] YASUHIDE SUZUKI, MITSUO IINUMA, SAYOKO YASUI, MAKI TAKATA, YOSHIE MINEDA and YASUO TAMURA: "EFFECTS OF TOOTH ABSENCE ON THE GROWTH, AGING AND LIFE SPAN IN SAM P-1 MICE"JPN. J. PED. DENT. 40(1). 103-113 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 鈴木康秀, 飯沼光生, 安井清子, 高田真希, 峯田淑子, 田村康夫: "歯の喪失が老化促進マウス(SAMP1)が成長老化に及ぼす影響"小児歯科学雑誌. 40巻1号. 103-113 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木康秀, 飯沼光生, 安井清子, 高田真希, 峯田淑子, 田村康夫: "歯の喪失が老化促進マウス(SAMP1)が成長老化に及ぼす影響"小児歯科学雑誌. 40巻1号(3月発刊のため未定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 飯沼光生: "咀嚼の発達と老化・寿命 その1吸啜から咀嚼への移行に歯の果たす役割は?"小児歯科臨床. 6巻6号. 66-73 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 飯沼光生: "咀嚼の発達と老化・寿命 その2咀嚼の発達に離乳は必須であろうか?"小児歯科臨床. 6巻7号. 59-65 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 飯沼光生: "咀嚼の発達と老化・寿命 その3咀嚼の低下が老化、寿命に影響を及ぼすだろうか?"小児歯科臨床. 6巻8号. 71-77 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 飯沼光生: "歯の喪失が老化促進マウスの成長、老化に及ぼす影響"老化促進モデルマウス研究協議会誌. 16. 35-36 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 発表者(飯沼光生 他): "歯界展望 増刊号 歯科医学と健康の創造 第19回日本歯科医学会総会、第22回アジア太平洋歯科大会"医歯薬出版株式会社. 381 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 平良梨津子、飯沼光生他: "粉末食飼育が老化促進マウス(SAM P1)の成長・老化に及ぼす影響"小児歯科学雑誌. 37巻4号. 798-809 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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