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MEF plays a role in the pathogenesis of alveolar proteinosis.

Research Project

Project/Area Number 11672174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionKumamoto University

Principal Investigator

KAI Hirofumi  Faculty of Pharmaceutical Sciences, Kumamoto University, Associate Professor, 薬学部, 助教授 (30194658)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsGM-CSF / MEF / ETS / EPITHELIUM / lysozyme
Research Abstract

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), a cytokine being expressed in lung epithelial cells, has a major role in the immune, differentiating and inflammatory milieu of airway. We found that ETS-2 positively transactivated GM-CSF expression by protein kinase C pathway and that MEF inhibited ETS-2 binding to DNA consensus sequence (GGAA) in the GM-CSF promoter.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Y.Isohama,M.Kanemaru,H.Kai,K.Takahama and T.Miyata: "Interaction between β-adrenergic signaling and protein kinase C increases cytoplasmic Ca^<2+> in alveolar type II cells."Life Sciences. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takahashi K., et al.: "Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats"Nippon Yakurigaku Zasshi. 116・6. 371-378 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okumura M., et al.: "Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes"European Journal of Pharmacology. 403. 189-194 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kai, et al.: "MEF up-regulates lysozyme transcription in epithelial cells"J.Biol.Chem.. 274. 20098-20102 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nagayama,H.Kai, et al.: "Characterization of CFTR expression in a human pulmonary mucoenidermoid carcinoma cell line NCIH292 cells."FEBS Letter. 455. 215-218 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Okumura,H.Kai, et al.: "Effects of eosinophil-granule MBP on phosphatidylcholine secretion in rat type II pneumocytes."Am.J.Physiol.. 276. 763-768 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Okumura, H.Kai, et al.: "Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes."Eur.J.Pharmacol.. 403. 189-194 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Suzuki, F.Shono, H.Kai, T.Uno, and M.Uyeda: "Inhibition of topoisomerases by fatty acids."J.Enz.Inhib.. 15. 357-366 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kai, et al.: "MEF up-regulates lysozyme transcription in epithelial cells."J.Biol.Chem.. 274. 20098-20102 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nagayama, H.Kai, et al.: "Characterization of CFTR expression in a human pulmonary mucoepidermoid carcinoma cell line, NCIH292 cells."FEBS Letter. 455. 215-218 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Okumura, H.Kai, et al.: "Effects of eosinophil-granule MBP on phosphatidylcholine secretion in rat type II pneumocytes."Am.J.Physiol.. 276. L763-L768 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Isohama,M.Kanemaru,H.Kai,K.Takahama and T.Miyata: "Interaction between β-adrenergic signaling and protein kinase C increases cytoplasmic Ca^<2+> in alveolar type II cells."Life Sciences. 印刷中. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takahashi K., et al.: "Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats"Nippon Yakurigaku Zasshi. 116・6. 371-378 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okumura M., et al.: "Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes"European Journal of Pharmacology. 403. 189-194 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Tai: "Effect of deoxyribonuclease 1 on tracheal mucociliary transport and airway secretion in anaesthetized quails"Pharmacol.Rev.Commun.. 10. 257-264 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kai: "MEF up-regulates lysozyme transcription in epithelial cells."J.Biol.Chem.. 274. 20098-20102 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Okumura: "Effects of eosinophil-granule major basic protein on phosphatidylcholine secretion in rat type II pneummocytes"Am.J.Physiol.. 276. 763-768 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Nagayama: "Characterization of CFTR expression in a human pulmonary mucoepidermoid carcinoma cell line,NCIH292 cells"FEBS Letter. 455. 215-218 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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