MEF plays a role in the pathogenesis of alveolar proteinosis.
| Project/Area Number |
11672174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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|---|
| Research Institution | Kumamoto University |
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Principal Investigator |
KAI Hirofumi Faculty of Pharmaceutical Sciences, Kumamoto University, Associate Professor, 薬学部, 助教授 (30194658)
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|---|
| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | GM-CSF / MEF / ETS / EPITHELIUM / lysozyme |
|---|
| Research Abstract |
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), a cytokine being expressed in lung epithelial cells, has a major role in the immune, differentiating and inflammatory milieu of airway. We found that ETS-2 positively transactivated GM-CSF expression by protein kinase C pathway and that MEF inhibited ETS-2 binding to DNA consensus sequence (GGAA) in the GM-CSF promoter.
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Report
(3 results)
Research Products
(18 results)
