| Project/Area Number |
11672217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
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| Research Institution | Kyoritsu College of Pharmacy |
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Principal Investigator |
MASHINO Tadahiko Kyoritsu College of Pharmacy, Faculty of Pharmaceutical Sciences, Associate Professor (90165697)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Satoko Kyoritsu College of Pharmacy, Faculty of Pharmaceutical Sciences, Research Associate (70223518)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Vitamin C / Vitamin E / Ascorbic acid / Tocopherol / Antioxidant / reductic acid / キサンチンオキシダーゼ / 痛風治療薬 |
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| Research Abstract |
Reactive oxygen species (ROS) and free radicals induce oxidative stress and play the important role in developing and/or progression of human diseases such as cancer. So, antioxidants are expected to be a good lead compounds for medicines. In this study, we developed excellent antioxidants based vitamin C and E.
1. Vitamin E analogs
We designed and synthesized benzo[h]chroman compounds (BC) which had benzene ring fused with vitamin E skelton and examined superoxide and OH radical quenching activity by ESR spin-trapping methods. Both activities were higher than that of trolox, which is vitamin E water-soluble analog.
2. Vitamin C analogs
Reductic acid (RA) which has a 2,3-enediol moiety conjugated with a carbonyl group in a five-membered carbon ring was synthesized. RA inhibited xanthine oxidase activity, while ascorbic acid did not.
RA quenched free radicals and also decreases active oxygen production. RA is thought to be a more potent inhibitor of active oxygen toxicity than ascorbic acid.
Xanthine oxidase produces uric acid, which plays a crucial role in goat. Therefore, xanthine oxidase inhibitor works as a medicine for goat. RA is thought to be a promising inhibitor for oxidative stress and remedy for goat.
Our data showed that BC and RA serves as a new starting structure for the design of pharmacologically effective compounds such as cancer.
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