| Project/Area Number |
11672223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
|
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| Research Institution | NATIONAL INSTITUTE OF HEALTH SCIENCES |
|---|
Principal Investigator |
KURIHARA Masaaki 国立医薬品食品衛生研究所, 有機化学部, 第一室長 (20205206)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYATA Naoki 国立医薬品食品衛生研究所, 有機化学部, 部長 (50114674)
|
|---|
| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | enediyne / Bergman reaction / trigger / DNA cleavage |
|---|
| Research Abstract |
It is an interesting challenge to design alternate frameworks and triggering mechanisms, with the goal of producing a stable enediyne which can be activated under controlled conditions, especially in away which directs the cytotoxicity toward a specific pathogen or tissue.
I found simple trigger of cycloaromatization in enediyne system. This enediyne compound were activated by deprotection to cleave DNA.
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