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Vascular effect of insulin as a vasoactive peptide and its resistance

Research Project

Project/Area Number 11672261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

KAWASAKI Hiromu  Okayama University, Graduate School of Natural Science and Technology, Professor, 大学院・自然科学研究科, 教授 (60125151)

Co-Investigator(Kenkyū-buntansha) KUROSAKI Yuji  Okayama University, Graduate School of Natural Science and Technology, Associate Professor, 大学院・自然科学研究科, 助教授 (90161786)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsINSULIN / VASCULAR RESPONSIVENESS / PERIARTERIAL NERVE FUNCTION / INSULIN-RESISTANT RAT / CALCITONIN GENE-RELATED PEPTIDE-CONTAINING NERVE / MESENTERIC RESISTANCE ARTERY / ADRENERGIC NERVE / 含硫アミノ酸タウリン / 血管内皮機能 / 交感神経 / 血管拡張性神経
Research Abstract

Vascular responsiveness and effect of long-term treatment (4 weeks) with troglitazone, taurine, L-compound (novel angiotensin II antagonist) or combined treatment of both drugs on vascular responsiveness were studied in the mesenteric artery of fructose-fed insulinresistant rats. Male SD rats (6-week-old) were divided into six groups : control group ; high-fructose (60%) chow-fed group (FFR), 0.2% troglitazone-treated FFR, taurine (3%) in drinking water-treated FFR, 0.002% L-compound-treated FFR or 0.2% troglitazone plus 3% taurine-treated FFR.After the 10-hr fast, blood samples were obtained, and mean blood pressure (MBP) were measured. There was no significant difference in blood glucose and MBP among each groups, whereas serum immunoreactiveinsulin and triglyceride value were higher in FFR than in normal rat. Taurine, troglitazone, L-compound or troglitazone+taurine treatment decreased serum levels of insulin and triglyceride in FFR.In perfused mesenteric vascular beds, periarterial nerve stimulation (PNS)-induced vasoconstriction was greater in FFR than in control. Treatment with troglitazone but not taurine reduced PNS-induced vasoconstriction. In preparation with active tone by methoxamine in the presence of guanethidine, calcitonin gene-related peptide (CGRP)-and sodium nitroprusside-induced vasodilation were no change among each groups. PNS-, acetylcholine-, and insulin-induced vasodilation were smaller in FFR than in normal rat. Taurine, troglitazone, L-compound or troglitazone +taurinetreatment augmented these responses. These results suggest that, in mesenteric artery of FFR, taurine as well as troglitazone restores decreased CGRP-nerved function, endothelial function and insulin-induced vasodilation.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 川崎博已 他2名: "インスリンの血管作用"日本薬理学雑誌. 115巻. 28-293 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawasaki H, Kuroda S, Mimaki Y: "Vascular effects of insulin."Folia Pharmacol.Jpn. 115. 287-293 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川崎博已 他2名: "インスリンの血管作用"日本薬理学雑誌. 115巻. 28-293 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川崎博己他2名: "インスリンの血管作用"日本薬理学雑誌. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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