| Project/Area Number |
11672269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Nagano College of Nursing |
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Principal Investigator |
IWATSUKI Kazuhiko College of Nursing, Nursing, Professore, 看護学部, 教授 (20004666)
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA Shigetoshi Shinshu University, School of Medicine, Professore, 医学部, 教授 (30004659)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | PRESSURE SORE / ADENOSINE / CPA / CGS21680 / ADENOSINE A_<2A> / DOG PANCREATIC EXOCRINE SECRETION / アデノシンA_<2A>受容体 / イヌ摘出脾動脈 / α,β-methyleneATP / P2X-プリン受容体 |
|---|
| Research Abstract |
Effects of adenosine receptor agonists of the pancreatic exocrine secretion were examined in anesthetized dogs. Graded doses of CGS21680 (1-300 nmol/kg), a selective adenosine A_<2A> receptor agonist, produced dose-dependent increasein the secretory rate of pancreatic juice, with a maximum effect at approximately 30 nmol/kg. However, CPA (1-300 nmol/kg), a selective adenosine A_1 receptor agonist, did not cause the pancreatic secretion. CGS21680 (3-30 nmol/kg) and secretin (0.01-0.03 pmol/kg) increased the bicarbonate concentration in pancreatic juice and decreased the protein concentration. DMPX (5-50 nmol/kg), a weak adenosine A_<2A> receptor antagonist, caused a progressive parallel shift to the right in the dose -response curve for CGS21680-induced pancreatic secretion without changes in the maximal response. DPCPX (100 nmol/kg), a selective A_1 adenosine receptor antagonist, did not antagonize the CGS21680-induced pancreatic secretion. These results suggest the existence of adenosine A_<2A> receptors in the exocrine cells of dog pancreas, involved in the water and bicarbonate secretory response.
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