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Plant components modifies the absorption, metabolism and excretion of xenobiotics.

Research Project

Project/Area Number 11680136
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 食生活
Research InstitutionUniversity of Shizuoka

Principal Investigator

KINAE Naohide  Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Prof., 食品栄養科学部, 教授 (00046286)

Co-Investigator(Kenkyū-buntansha) HIMOI Kayoko  Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Assist. Prof., 食品栄養科学部, 助手 (10162728)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsantioxidative potency / antimutaenicity / radical scavenging pote / catechin / sea lettuce / flavonoid / metabolism / adsorption / MX / ベンツ(a)ピレン / 吸収 / 排泄 / 抗酸化物質 / 食物繊維 / ベンズ(a)ピレン
Research Abstract

In this study several effective components were isolated from green tea and seaweeds, which show antioxidative, radical scavenging and antimutagenic activities. The modification potency of these components to absorption, metabolism and excretion of xenobiotics were examined in vivo and in vitro.
1. The methanol extract of sea lettuce (Ulva pertusa kjellman) showed antioxidative activity in a dose dependent manner at the range of 0.5 to 5.0 mg/ml. But the potency of water extract was 20 % compared to that of the methanol extract. And radical scavenging activity (ED_50) of the methanol extract was 0.7-1.6 mg/ml. Moreover, the methanol extract inhibited the mutagenicity of MelQx and Trp P-1 which were formed in cooked meat arid fish.
2. Green tea extract suppressed the mutagenicity of nitrosomorpholine (34% in 0.5 mg/plate, 70 % in l.0 mg/plate). Green tea extract also inhibited the formation of nitrosomorpholine in rat oral administered sodium nitrite and morpholine.
3. Several flavonoids containing quercetin and rutin, and food fiber such as chitin, chitosan and cellulose showed the strong adsorption potency to DOT having carcinogenicity and endocrine disrupting activity.
From these data, the intake of plant components including flavonoids may. be beneficial tool to detoxify many xenobiotics by modification of absorption, metabolism and excretion steps.

Report

(3 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Miyake, Y.: "Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats"J. Agric. Food Chem.. 48(8). 3217-3224 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arai, Y.: "Dietary intake of flavonol, flavone and isoflavone in Japanese women: The quercetin intake inversely associated with the plasma LDL cholesterol concentration"J. Nutrition. 133. 2243-2250 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi, K.: "Metabolic fate of luteolin and its functional activity at focal site"Bio-Factors. 12. 181-186 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinae, N: "Functional properties of wasabi and horseradish"Bio-Factors. 13. 265-269 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi, K.: "Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cells"Mutat. Res.. 480-481(1-2). 371-378 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi, K.: "Deglucuronidation of aflavonoid, luteolin monoglucuronide, during inflammation"Drug Metab Dispos. 29(12). 1521-1524 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 下位香代子: "食品と開発"植物ブラボノイドの最新機能研究. 3 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 木苗直秀: "Food & Food Ingredients Journal of Japan"沢ワサビの機能性を考える. 7 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyake Y., Shimoi K., Kumazawa S., Yamamoto K., Kinae N. and Osawa T.: "Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats"J. Agric. Food Chem.. 48(8). 3217-3224 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arai Y,, Watanabe S., Kimira M., Onodera J., Chida A. Onodera H., Ikeno T., Shimoi K,. Mochizuki R., and Kinae N.: "Dietary intake of Nutrition flavonol, flavone and isoflavone in Japanese women : The quercetin intake inversely associated with the plasma LDL cholesterol concentration"J. Nutrition. 130. 2243-2250 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi K., Saka N., Kaji K., Nozawa R. and Kinae N.: "Metabolic fate of luteolin and its functional activity at focal site"Bio-Factors. 12. 181-186 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] kinae N. Masuda H., Shin I. S., Furugori M. and Shimoi K.: "Functional properties of wasabi and horseradish"Bio-Factors. 13. 265-269 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi K., Okitsu A., Green M. H. L., Lowe J. E., Ohta T., Kaji K., Terato H. Ide H. and Kjnae N.: "Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cells"Mutat. Res.. 480-481(1-2). 371-378 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimoi K., Saka,N., Nozawa,R., Sato,M., Amano I., Nakayama T. and Kinae N.: "Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation"Drug Metab Dispos.. 29(12). 1521-1524 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyake Y.,Kinae N., et al: "Identification and antioxidant activity of flavonoid metabolites in plasma urine of eriocitrin-treated rats."J.Agric.Food Chem.,. 48. 3217-3224 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Arai Y.,Kinae N., et al: "Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse corrlation between quercetin and plasma LDL cholesterol concentration."J.Nutr.,. 130. 2243-2250 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimoi K.,Kinae N., et al: "Metabolic fate of luteolin and its functional activity at focal site."Biofactors. 12. 181-186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kinae N., et al: "Functional properties of wasabi and horseradish."Biofactors. 13. 265-269 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 下位香代子,木苗直秀: "植物フラボノイドの最新機能研究"食品と開発. 35(6). 8-10 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishikawa A,Kinae N.et al.: "Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine"Cancer Res.,. 59(9). 2045-2049 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirose A,Kinae N.et al.: "3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX):Toxicological properties and risk assessment in drinking water"Rev.Environ.Health. 14(3). 103-120 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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