| Project/Area Number |
11680328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Science University of Tokyo |
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Principal Investigator |
ISAO Yoshimura Science University of Tokyo, Faculty of Engineering Professor, 工学部, 教授 (30010797)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大森 崇 東京理科大学, 工学部, 助手 (50318218)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | toxicological expesiment / date analysis / dose-respose relationship / mouse lymphoma assay / transformation assay / synergism / マウスリンフォーマ試験 / 代謝協同阻害試験 / 統計解析 / 用量反応関係 / インビトロ毒性試験 / 実験計画 |
|---|
| Research Abstract |
This study addressed some statistical issues realized in in-vitro toxicological experiments such as the mouse lymphoma assay, transformation assay, and mutagenecity tests.A new method for data analysis was proposed on the mouse lymphoma assay, the result of which was presented and discussed at the workshop held on March 14-16, 2001 at San Diego. The content will be submitted to the "Mutation Research" by four authors Omori, Hayashi, Homma and Yoshimura. The utilization of a Margolin procedure in a validation study on the transformation assay was proposed, the result of which was published on the "Alternatives to Laboratory Animals." A proposal for the design and analysis
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