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Vascular regulation by kringles of HGF and molecular cloning of a novel kringle-containing protein

Research Project

Project/Area Number 11680631
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionOsaka University

Principal Investigator

MATSUMOTO Kunio  Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90201780)

Co-Investigator(Kenkyū-buntansha) KOSHIMIZU Uichi  Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (50281126)
FUNAKOSHI Hiroshi  Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40273685)
NAKAMURA Toshikazu  Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 (00049397)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsHGF / kringle domain / NK4 / angiogenesis / tumor angiogenesis / Kremen / metastasis / pancreatic cancer / 肝細胞増殖因子 / HGT / 癌治療 / クリングル / 制癌剤
Research Abstract

Various proteins containing kringle domains play diverse roles in tissue regeneration, blood coagulation/fibrinolysis, neural development, and blood vessel regulation. Identification of a novel kringle-containing molecule is likely to lead to further understanding of blood vessel regulation, including angiogenesis and anti-angiogenesis. In the present study, to study regulatory mechanisms by which kringle domains exhibit angio-regulatory functions, we analyzed angiostatic action of NK4, previously identified as HGF-antagonist. Likewise, we succeeded in molecular cloning of a novel kringle-containg molecule, Kremen.
1) NK4 as angiogenesis inhibitor : NK4, a four kringles-cpontaining HGF-antagonist, inhibited proliferation and migration of vascular endothelial cells in culture. Likewise, NK4 inhibited angiogenesis in CAM and cornea assays in vivo. Together with a previously characterized biological action of NK4 as HGF-antagonist, therapeutic potential of NK4 for treatment of metastatic c … More ancers were tested. NK4 administered into mice potently suppressed metastasis, tumor angiogenesis, and tumor growth of cancers, including lung, breast, and pancreatic cancers. NK4 will become a potent anti-cancer agent, targeting malignant behavior of cancer.
2) Using a newly established cloning strategy for kringle-containg proteins, 'Kringle-SAGE', we cloned cDNA for Kremen. Kremen is composed of 473 amino acids and is type-I transmembrane protein. Kremen contains unique domains, kringle domain and CUB domain in its extracellular region, while it has no specific conserved functional motif in its intracellular region. Kremen mRNA is expressed in diverse tissues, while it is up-regulated during muscular and neural differentiation. Kringle domain of Although Kremen may have some roles in vascular regulation and differentiation of muscular and neural cells, its roles remain to be further addressed. A newly established method for comprehensive cloning of kringle-proteins, Kringle-SAGE is powerful in molecular cloning of kringle proteins. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (203 results)

All Other

All Publications (203 results)

  • [Publications] T.Ueki, et al.: "Hepatocyte growth factor gene therapy of liver cirrhosis in rats"Nature Med.. 5. 226-230 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Liu, et al.: "Upregulation of hepatocyte growth factor receptor : an amplification and targeting mechanis for hepatocyte growth factor action in acute renal failure."Kidney Intem.. 55. 442-453 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Tahara, et al.: "Hepatocyte gowth factor leads to recovery from alcohol-induced fatty liver in rats"J.Clin.Invest.. 103. 313-320 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Wojta, et al.: "Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Evidence for a paracrine loop in wound healing"Lab.Invest.. 79. 427-438 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Z.Jiao, et al.: "Effect of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long Evans Cinamon rats"Jp.J.Cancer Res.. 90. 496-506 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Azuma, et al.: "Effect of hepatocyte growth factor on chronic rejection in rat renal allografts"Transplat.Proc.. 31. 854-855 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Takada, et al.: "Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats"Transpl.Int.. 12. 27-32 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ueda, et al.: "Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart"Annals.Thoracic Surg.. 67. 1726-1731 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kosai, et al.: "Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice"Hepatology. 30. 151-159 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Hasina, et al.: "Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line"Brit.J.Cancer. 80. 1708-1717 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kitajima, et al.: "Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds"Develop.Dyn.. 215. 206-214 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Taniura-Matsumoto, et al: "Prostaglandin production in mouse mammary carcinoma cells confers invasive growth potential by inducing hepatocyte growth factor in fibroblasts"Brit.J.Cancer. 81. 194-202 (1999)

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      2000 Final Research Report Summary
  • [Publications] M.Kato, et al.: "Efficient extraction by the liver govems the overall elimination of hepatocyte growth factor in rats."J.Pharmacol.Exp.Therap.. 290. 373-379 (1999)

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      2000 Final Research Report Summary
  • [Publications] R.Morishita, et al.: "Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as a cytokine supplement therapy"Hypertention. 33. 1379-1384 (1999)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.G.Jiang, et al.: "Hepatocyte growth factor/scatter factor decreases the expression of occuludin and transendothelial resistance (TER) and increased paracellular permeability in human vascular endothelial cells"J.Cell.Physiol.. 181. 319-329 (1999)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] C.C.Fehlner-Gardiner, et al.: "Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cells"Differentiation. 65. 27-42 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Deleu, et al.: "Immediate early gene expression in dog thyrocytes in response to growth proliferation and differentiation stimuli"J.Cell.Physiol.. 182. 342-354 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Deleu, et al.: "IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis"Mol.Cell.Endocrinol.. 149. 41-51 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hayashi, et al.: "Potential role of hepatocyte growth factor, a novel angiogenic growth factor in peripheral arterial disease : Downregulation of HGF in response to hypoxia in vascular cells"Circulation. 100. II301-II308 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nagahori, et al.: "Interferon-gamma upregulates the c-Met/HGF receptor expression in alvedar epithelial cells"Am.J.Respir.Cell Mol.Biol.. 21. 490-497 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] O.Amano, et al.: "Enhancement by hepatocyte growth factor (HGF) of bone and cartilage formation duringt embryonic mouse mandibular development in vitro"Arch.Oral Biol.. 44. 935-946 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Nishimura, et al.: "Prostate stromal cell-derived hepatocyte growth factor induces invasion of prostate cancer cells DU 145 through Tumor-stromal interaction"Prostate. 41. 145-153 (1999)

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      2000 Final Research Report Summary
  • [Publications] W.Sun, et al.: "Differential expression of hepatocyte growth factor and its receptor, c-Met in the rat retina during development"Brain Res.. 851. 46-53 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Uchiyama, et al.: "Hepatocyte growth factor and invasion-stimulatory activity are induced in pleural fluid by surgery in lung cancer patients"Brit.J.Cancer. 81. 721-726 (1999)

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      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Prevention of renal damage by Angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats"Hypertension. 34. 279-284 (1999)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Okura, et al.: "Analysis of neurotrophic factor of hepatocyte growth factor (HGF) in the adult hypoglossal nerve axotomy model"Eur J.Neurosci.. 11. 4139-4144 (1999)

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      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] T.Sumi, et al.: "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by Rho-and Cdc42-activated LIM-kinase2"J.Cell Biol.. 147. 1519-1532 (1999)

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      2000 Final Research Report Summary
  • [Publications] M.K.Jones, et al.: "HGF triggers activation of Cox-2 gene in rat gastric epithelial cells : Action mediated through the ERK2 signalling pathway"FASEB J.. 13. 2186-2194 (1999)

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      2000 Final Research Report Summary
  • [Publications] Y.Kawano, et al.: "Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo"J.Cell Biol.. 147. 1023-1037 (1999)

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      2000 Final Research Report Summary
  • [Publications] W.G.Jiang, et al.: "Antagonistic effect of NK4, a novel HGF variant, on in vitro angiogenesis of human vascular endothelial cells"Clin.Cancer Res.. 5. 3695-3703 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] C.Parr, et al.: "NK4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the matility and invasion of colon cancer cells"Intem.J.Cancer. 85. 563-570 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] S.Hiscox,: "Inhibition of HGF/SF-induced breast cancer cell matility and invasion by the HGF/SF variant, NK4"Breast Cancer Res.& Treat.. 59. 245-254 (2000)

    • Description
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      2000 Final Research Report Summary
  • [Publications] M.Nakano,: "Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts"Transplantation. 69. 214-221 (2000)

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      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice"Kidney Int.. 57. 937-948 (2000)

    • Description
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      2000 Final Research Report Summary
  • [Publications] W.Sum, et al.: "A sensitive quantification method for evaluating the level of hepatocyte growth factor (HGF) and c-met/HGF receptor mRNA in the nervous system using competitive RT-PCR"Brain Res.Protocol. 5. 190-197 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Beppu, et al.: "Elevation of serum hepatocyte growth factor concentration in patients with gastric cancer is mediated by production by tumor tissue"Anticancer Res.. 20. 1263-1268 (2000)

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      2000 Final Research Report Summary
  • [Publications] M.Aoki, et al.: "Angiogentesis induced by hepatocyte growth factor in non-infarcted myocardium and iufarcted myocardium : up-regalation of essential transcription factor for angiogenesis, ets"Gene Therapy. 7. 417-427 (2000)

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      2000 Final Research Report Summary
  • [Publications] T.Yamada, et al.: "Enhanced expression of hepatocyte growth factor by pulmonary ischemia reperfusion injury in the rat"Am.J.Resp.Crit Care Med.. 162. 707-715 (2000)

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    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Taniyama, et al.: "Potential contribution of a novel anti-fibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamster"Circulation. 102. 246-252 (2000)

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      2000 Final Research Report Summary
  • [Publications] T.Kunisaka, et al.: "Keratinocyte expression of transgenic hepatocyte growth factor (HGF) affects melanocyte development, leading to dermal melanocytosis"Mech.Dev.. 94. 67-78 (2000)

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      2000 Final Research Report Summary
  • [Publications] G.H.Lai, et al.: "Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated"intestinal-type"of biliary cancer chemically-induced in rat liver"Hepatology. 31. 1257-1265 (2000)

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      2000 Final Research Report Summary
  • [Publications] J.-M.Otte, et al.: "Functional expression of HGF and its receptor in human colorectol Cancer"Digestion. 61. 237-246 (2000)

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      2000 Final Research Report Summary
  • [Publications] O.Muto, et al.: "HGF/SF-induced spreading of MDCK cells corelates with disappearance of barmotin/7H6, a tight junction-associated protein, from the cell membrane"Cell Biol.Intern.. 24. 439-446 (2000)

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      2000 Final Research Report Summary
  • [Publications] T.Kikuchi, et al.: "Secretory leukoprotease inhibitor augments hepatocyte growth factor production in human lung fibroblasts"Am.J.Respir.Cell Mol.Biol.. 23. 364-370 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Hayashi, et al.: "In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelization and inhibition neointimal formation after balloon injury in rat model"Gene Therapy. 7. 1664-1671 (2000)

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      2000 Final Research Report Summary
  • [Publications] H.Nakagami, et al.: "Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells"J.Hypertension. 18. 1411-1420 (2000)

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      2000 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF"J.Clin.Invest.. 106. 1511-1519 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Kuba, et al.: "HGF/NK4, a four-kringle fragment of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice"Cancer Res.. 60. 6737-6743 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Kuba, et al.: "Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells"Biochem.Biophys.Res Commun.. 279. 846-852 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Hepatocyte growth factor in renal regeneration, renal disease, and potential therapeutics"Curr.Opin.Nephrol.Hypertention. 9. 395-402 (2000)

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      2000 Final Research Report Summary
  • [Publications] G.Shiota, et al.: "In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats"FEBS Lett.. 470. 325-330 (2000)

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      2000 Final Research Report Summary
  • [Publications] T.Takahashi, et al.: "Functional involvement of LIM-kinase in Xenopus oocyte maturation"Develop.Biol.. 229. 554-567 (2001)

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      2000 Final Research Report Summary
  • [Publications] T.Sumi, et al.: "Specific activation of LIM-kinase 2 via phosphorylation of the threonine-505 by ROCK, a Rho-dependent protein kinase"J.Biol.Chem. 147. 670-676 (2001)

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      2000 Final Research Report Summary
  • [Publications] H.Azuma, et al.: "Hepatocyte growth factor prevents development of chronic allograft nephropathy in an experimental rat transplant model"J.Am.Soc.Nephrol.. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy"Kidney Int.. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] N.Maehara, et al.: "NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells"Br.J.Cancer. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] N.Tsuzuki, et al.: "Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia"Neurol.Res.. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein"Biochim.Biophys.Acta. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Hepatocyte growth factor : renotropic role and potential therapeutics for renal diseases"Kidney Int.. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] H.Ueda,, et al.: "A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats"Cardiovascular Res.. (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.(分担執筆): "Cancer Metastasis : Molecular & Cellular Mechanisms and Clinical Interventions"Kluwer Academic Publishers(分担分). 50 (2000)

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      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.(分担執筆): "Growth Factors and Their Receptors in Cancer Metastasis"Kluwer Academic Publishers (In press). (2001)

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      2000 Final Research Report Summary
  • [Publications] T.Ueki, et al.: "Hepatocyte growth factor gene therapy of liver cirrhosis in rats."Nature Medicine. 5. 226-230 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Liu, et al.: "Upregulation of hepatocyte growth factor receptor : an amplification and targeting mechanis for hepatocyte growth factor action in acute renal failure."Kidney Intern.. 55. 442-453 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Tahara, et al.: "Hepatocyte gowth factor leads to recovery from alcohol-induced fatty liver in rats."J.Clin.Invest.. 103. 313-320 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Wojta, et al.: "Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Evidence for a paracrine loop in wound healing."Lab.Invest. 79. 427-438 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Z.Jiao, et al.: "Effect of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long Evans Cinamon rats."Jp.J.Cancer Res.. 90. 496-504 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Azuma, et al.: "Effect of hepatocyte growth factor on chronic rejection in rat renal allografts."Transplat.Proc.. 31. 854-855 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Takada, et al.: "Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats."Transpl.Int.. 12. 27-32 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ueda, et al.: "Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart."Annals.Thoracic Surg.. 67. 1726-1731 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kosai, et al.: "Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice."Hepatology. 30. 151-159 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Hasina, et al.: "Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line."Brit.J.Cancer. 80. 1708-1717 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kitajima, et al.: "Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds."Develop.Dyn.. 215. 206-214 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Taniura-Matsumoto, et al.: "Prostaglandin production in mouse mammary carcinoma cells confers invasive growth potential by inducing hepatocyte growth factor in fibroblasts."Brit.J.Cancer. 81. 194-202 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Kato, et al.: "Efficient extraction by the liver governs the overall elimination of hepatocyte growth factor in rats."J.Pharmacol.Exp.Therap.. 290. 373-379 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Morishita, et al.: "Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as a cytokine supplement therapy."Hypertention. 33. 1379-1384 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.G.Jiang, et al.: "Hepatocyte growth factor/scatter factor decreases the expression of occuludin and transendothelial resistance (TER) and increased paracellular permeability in human vascular endothelial cells."J.Cell.Physiol.. 181. 319-329 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] C.C.Fehlner-Gardiner, et al.: "Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cells."Differentiation. 65. 27-42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Deleu, et al.: "Immediate early gene expression in dog thyrocytes in response to growth proliferation and differentiation stimuli."J.Cell.Physiol.. 181. 342-354 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Deleu, et al.: "IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis."Mol.Cell.Endocrin.. 149. 41-51 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hayashi, et al.: "Potential role of hepatocyte growth factor, a novel angiogenic growth factor in peripheral arterial disease : Downregulation of HGF in response to hypoxia in vascular cells."Circulation. 100. II-301-308 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nagahori, et al.: "Interferon-gamma upregulates the c-Met/HGF receptor expression in alvedar epithelial cells."Am.J.Respir.Cell Mol.Biol.. 21. 490-497 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] O.Amano, et al.: "Enhancement by hepatocyte growth factor (HGF) of bone and cartilage formation during embryonic mouse mandibular development in vitro."Arch.Oral Biol.. 44. 935-946 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Nishimura, et al.: "Prostate stromal cell-derived hepatocyte growth factor induces invasion of prostate cancer cells DU 145 through Tumor-stromal interaction."Prostate. 41. 145-153 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.Sun, et al.: "Differential expression of hepatocyte growth factor and its receptor, c-Met in the rat retina during development."Brain Res.. 851. 46-53 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Uchiyama, et al.: "Hepatocyte growth factor and invasion-stimulatory activity are induced in pleural fluid by surgery in lung cancer patients."Brit.J.Cancer.. 81. 721-726 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Prevention of renal damage by Angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats."Hypertension.. 34. 279-284 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Okura, et al.: "Analysis of neurotrophic factor of hepatocyte growth factor (HGF) in the adult hypoglossal nerve axotomy model."Eur J.Neurosci.. 11. 4139-4144 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Sumi, et al.: "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by Rho-and Cdc42-activated LIM-kinase2."J.Cell Biol.. 147. 1519-1532 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.K.Jones, et al.: "HGF triggers activation of Cox-2 gene in rat gastric epithelial cells : Action mediated through the ERK2 signalling pathway."FASEB J.. 13. 2186-2194 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Kawano, et al.: "Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo."J.Cell Biol.. 147. 1023-1037 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.G.Jiang, et al.: "Antagonistic effect of NK4, a novel HGF variant, on in vitro angiogenesis of human vascular endothelial cells."Clin.Cancer Res.. 5. 3695-3703 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] C.Parr, et al.: "NK4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the matility and invasion of colon cancer cells."Intern.J.Cancer. 85. 563-570 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hiscox, et al.: "Inhibition of HGF/SF-induced breast cancer cell matility and invasion by the HGF/SF variant, NK4."Breast Cancer Res. & Treat.. 59. 245-254 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Nakano, et al.: "Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts."Transplantation. 69. 214-221 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice."Kidney Intern.. 57. 937-948 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.Sun, et al.: "A sensitive quantification method for evaluating the level of hepatocyte growth factor (HGF) and c-met/HGF receptor mRNA in the nervous system using competitive RT-PCR."Brain Res.Protocol. 5. 190-197 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Beppu, et al.: "Elevation of serum hepatocyte growth factor concentration in patients with gastric cancer is mediated by production by tumor tissue."Anticancer Res.. 20. 1263-1268 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Aoki, et al.: "Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium : up-regalation of essential transcription factor for angiogenesis, ets."Gene Therapy. 7. 417-427 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Yamada, et al.: "Enhanced expression of hepatocyte growth factor by pulmonary ischemia reperfusion injury in the rat."Am.J.Resp.Crit Care Med.. 162. 707-715 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Taniyama, et al.: "Potential contribution of a novel anti-fibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamster."Circulation. 102. 246-252 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kunisada, et al.: "Keratinocyte expression of transgenic hepatocyte growth factor (HGF) affects melanocyte development, leading to dermal melanocytosis."Mech.Dev.. 94. 67-78 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] G.H.Lai, et al.: "Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated "intestinal-type" of biliary cancer chemically-induced in rat liver."Hepatology. 31. 1257-1265 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.-M.Otte, et al.: "Functional expression of HGF and its receptor in human colorectol"Cancer.Digestion. 61. 237-246 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] O.Muto, et al.: "HGF/SF-induced spreading of MDCK cells corelates with disappearance of barmotin/7H6, a tight junction-associated protein, from the cell membrane."Cell Biol.Intern.. 24. 439-446 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kikuchi, et al.: "Secretory leukoprotease inhibitor augments hepatocyte growth factor production in human lung fibroblasts."Am.J.Respir.Cell Mol.Biol.. 23. 364-370 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Hayashi, et al.: "In vivo transfer of human hepatocyte growth factor gene accelerates reendothelization and inhibition neointimal formation after balloon injury in rat model."Gene Therapy. 7. 1664-1671 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Nakagami, et al.: "Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells."J.Hypertension. 18. 1411-1420 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF"J.Clin.Invest.. 106. 1511-1519 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuba, et al.: "HGF/NK4, a four-kringle fragment of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice."Cancer Res.. 60. 6737-6743 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuba, et al.: "Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells."Biochem.Biophys.Res Commun.. 279. 846-852 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] G.Shiota, et al.: "In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats."FEBS Lett.. 470. 325-330 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Hepatocyte growth factor in renal regeneration, renal disease, and potential therapeutics."Curr.Opin.Nephrol.Hypertention. 9. 395-402 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Takahashi, et al.: "Functional involvement of LIM-kinase in Xenopus oocyte maturation."Develop.Biol.. 229. 554-567 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Sumi, et al.: "Specific activation of LIM-kinase 2 via phosphorylation of the threonine-505 by ROCK, a Rho-dependent protein kinase."J.Biol.Chem. 147. 670-676 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Azuma, et al.: "Hepatocyte growth factor prevents development of chronic allograft nephropathy in an experimental rat transplant model."J.Am.Soc.Nephrol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy."Kidney Intern.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Maehara, et al.: "NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells."Br.J.Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Tsuzuki, et al.: "Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia."Neurol.Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein."Biochim.Biophys.Acta. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ueda, et al.: "A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats."Cardiovascular Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Hepatocyte growth factor : renotropic role and potential therapeutics for renal diseases."Kid.Intern.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumoto et al.: "Hepatocyte growth factor and Met in tumour invasion-metastasis : from mechanisms to cancer prevention."Cancer Metastasis : Molecular & Cellular Mechanisms and Clinical Interventions Kluwer Academic Publishers. 143-193 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "HGF-c-Met receptor pathway in tumor invasion-metastasis and potential cancer treatment with NK4."Growth Factors and Their Receptors in Cancer Metastasis (eds, Jiang, W.G., Matsumoto, K., Nakamura, T.), Kluwer Academic Publisher, (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuba,K., et al.: "HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppress tumor growth and metastasis in mice"Cancer Res.. 60. 6737-6743 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuba,K., et al.: "Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells"Biochem.Biophys.Res Commun.. 279. 846-852 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Parr,C., et al.: "NK4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells"Int.J.Cancer. 85. 563-570 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiscox,S., et al.: "Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4"Breast Cancer Res.Treat.. 1627. 1-10 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakamura,T., et al.: "Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF"J.Clin.Invest.. 106. 1511-1519 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsumoto,K., et al.: "Hepatocyte growth factor in renal regeneration, renal disease, and potential therapeutics"Curr.Opin.Nephrol.Hypertention. 9. 395-402 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mizuno,S., et al.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice"Kidney Int.. 57. 937-948 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sun,W., et al.: "A sensitive quantification method for evaluating the level of hepatocyte growth factor and c-met/HGF receptor mRNA in the nervous system using competitive RT-PCR"Brain Res. Protocol. 5. 190-197 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Beppu,K., et al.: "Elevation of serum hepatocyte growth factor concentration in patients with gastric canter is mediated by production from tumor tissue"Anticancer Res.. 20. 1263-1268 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamada,T., et al.: "Enhanced expression of hepatocyte growth factor by pulmonary ischemia reperfusion injury in the rats"Am.J.Respir.Crit.Care Med.. 162. 707-715 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Aoki,M., et al.: "Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium : up-regulation of essential transcription factor for angiogenesis, ets."Gene Ther.. 7. 717-727 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakagami,H., et al.: "Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells"J.Hypertens.. 18. 1411-1420 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hayashi,K., et al.: "In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model"Gene Ther.. 7. 1664-1671 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Taniyama,Y., et al.: "Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensis II blockade in cardiomyopathic hamsters"Circulation. 102. 246-252 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sumi,T., et al.: "Specific activation of LIM-kinase 2 via phosphorylation of the threonine-505 by ROCK, a Rho-dependent protein kinase"J.Biol.Chem.. 147. 670-676 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maehara,N., et al.: "NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells"Br.J.Cancer. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakamura,T., et al.: "Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein"Biochim.Biophys.Acta.. 93513(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsumoto,K., et al.: "Hepatocyte growth factor : renotropic role and potential therapeutics for renal diseases"Kid.Inthern.. 59(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mizuno,S., et al.: "Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy"Kidney Intern.. 59(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Azuma,H., et al.: "Hepatocyte growth factor prevents development of chronic allograft nephropathy in an experimental rat transplant model"J.Am.Soc.Nephrol.. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuzuki,N., et al.: "Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia"Neurol.Res.. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda,H., et al.: "A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats"Cardiovascular Res. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsumoto,K. et al.(分担執筆): "Cancer Metastasis : Molecular & Cellular Mechanisms and Clinical Interventions"Kluwer Academic Publisher(分担分). 50 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsumoto,K. et al.(分担執筆): "Growth Factors and Their Receptors in Cancer Metastasis"Kluwer Academic Publisher(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Ueki et al.: "Hepatocyte growth factor gene therapy of live cirrhosis in rats"Nature Medicine. 5. 226-230 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Liu et al.: "Upregulation of hepatocyte growth factor receptor : an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure,"Kidney Intern. 55. 442-453 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Tahara,K.Matsumoto,T.Nukiwa and T.Nakamura.: "Hepatocyte gowth factor leads to recovery from alcohol-induced fatty live in rats"J. Clin. Invest.. 103. 313-320 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] J.Wojta et al.: "Hepatocyte gowth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothlial growth factor receptor flk-1 in human endothelial cells. Evidence for a paracrine loop in wound healing"Lab. Invest. 79. 427-438 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Z.Jiar et al.: "Effect of D-galactosamine hydrochloride and partial helatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long Evans Cinamon rats"Jpn. J. Cancer Res.. 90. 496-504 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Azuma et al.: "Effect of hepatocyle growth factor on chronic rejection in rat renal allografts"Transplat. Proc.. 31. 854-855 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Takada et al.: "Effect of hepatocyle growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats"Transpl. Int.. 12. 27-32 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Ueda et al.: "Gene transfection of hepatocy growth factor attenuates reperfusion injury in the heart"Annals, Thoracic Surg.. 67. 1726-1731 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Kosai,K.Matsumoto,and T.Nakamura.: "Hepatocyte growth factor prevents endotoxin-induced lehal hepaitc failure in mice"Hepatology. 30. 151-159 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] R.Hasina et al.: "Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line"Brit. J. Cancer. 80. 1708-1717 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] k.Kitajima,U.Koshimizu and T.Nakamura.: "Expression of a novel type of classic cadherin,PB-cadherin in developing brain and limb buds"Develop. Dyn.. 215. 206-214 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Taniura-Matsumoto,K.Matsumoto and T.Nakamura.: "Prostaglandin production in mouse mammary carcinoma cells confers invasive growth potential by inducing hepatocyte growth factor in fibroblasts"Brit. J. Cancer. 81. 194-202 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Kato,Y.Kato,T.Nakamura and Y.Sugiyama.: "Efficient extraction by the liver governs the overall elimation of hepatocyte growth factor in rats"J. Pharmacol. Exp. Therap.. 290. 373-379 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Morishita et al.: "Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy"Hypertention. 33. 1379-1384 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] W.G.Jiang et al.: "Hepatocyte growth factor/scatter factor decreases the expression of occuludin and transendothelial resistance (TER) and incerased paracellular permeability in human vascular endothelial cells"J. Cell. Physiol.. 181. 319-329 (1999)

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      1999 Annual Research Report
  • [Publications] C.C.Fehlner-Gardiner et al.: "Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cells"Differentiation. 65. 27-42 (1999)

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      1999 Annual Research Report
  • [Publications] S.Deleu et al.: "Immediate early gene expression in dog thyrocytes in respones to growth proliferation and differentiation stimuli"J. Cell. Physiol.. 181. 342-354 (1999)

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      1999 Annual Research Report
  • [Publications] S.Deleu et al.: "IGF-1 or insulin,and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis,and complement each other in inducing mitogenesis"Mole. Cell. Endocrin.. 149. 41-51 (1999)

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      1999 Annual Research Report
  • [Publications] S.Hayashi et al.: "Potential role hepatocyte growth factor,a novel angiogenic growth factor in peripheral arterial disease: Downregulation of HGF in response to hypoxia in vascular cells"Circulation. 100. II-301-308 (1999)

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      1999 Annual Research Report
  • [Publications] T.Nagahori et al.: "Interferon-gamma upregulates the c-Met/HGF receptor expression in alvedar epithelial cells"Am. J. Respir. Cell Mol. Biol.. 21. 490-497 (1999)

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      1999 Annual Research Report
  • [Publications] O.Amano,U.Koshimizu,T.Nakamura and S.Iseki: "Enhancement by hepatocyte growth factor (HGF) of bone and cartilage formation during embryonic mouse mandibular development in vetro"Arch. Oral Biol.. 44. 935-946 (1999)

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      1999 Annual Research Report
  • [Publications] K.Nishimura et al.: "Prostate stromal cell-derived hepatocyte growth factor induces invasion of prostate cancer cells DU 145 through Tumor-stromal interaction"Prostate. 41. 145-153 (1999)

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      1999 Annual Research Report
  • [Publications] W.Sun,H.Funakoshi and T.Nakamura: "Differential expression of hepatocyte growth factor and its receptor,c-Mell in the rat retina retina during development"Brain Res.. 851. 46-53 (1999)

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      1999 Annual Research Report
  • [Publications] A.Uchiyama et al.: "Hepatocyte growth factor and invasion-stimulatory activity are induced in pleural fluid by surgery in Lung cancer patients"Br. J. Cancer. 81. 721-726 (1999)

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      1999 Annual Research Report
  • [Publications] K.matsumoto et al.: "Prevention of renal damage by Angiotensin II blockade,accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats"Hypertension. 34. 279-284 (1999)

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      1999 Annual Research Report
  • [Publications] Y.Okura et al.: "Anaiysis of neurotrophic factor of hepatocyte growth factor (HGF) in the adult hypoglossal nerve axotomy model"Eur J. Neurosci.. 11. 4139-4144 (1999)

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      1999 Annual Research Report
  • [Publications] T.Sumi,K.Matsumoto,Y.Takai and T.Nakamura: "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by Rho-and Cdc-42-activated LIM-kinase 2"J. Cell Biol.. 147. 1519-1532 (1999)

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      1999 Annual Research Report
  • [Publications] M.K.Jones et al.: "HGF triggers activation of Cox-2 gene in rat gastric epithelial cells Action mediated through the ERK2 signalling pathway"FASEBJ.. 13. 2186-2194 (1999)

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      1999 Annual Research Report
  • [Publications] Y.Kawano et al.: "Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo"J. Cell Biol.. 147. 1023-1037 (1999)

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      1999 Annual Research Report
  • [Publications] F.Tamura et al.: "FK506 promotes liver regeneration by suppressing natural killer cell activity"J. Gastroenterol. and Hepatol.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] A.Uchiyama et al.: "Significance of locally-secreted hepatocyte growth factor after thoracic cancer surgery as a stimulator for postoperative cancer invasion"Jpn. J. Clin. Oncol.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] W.G.Jiang et al.: "Antagonistic effect of NK4,a novel HGF variant,on in vitro angiogenesis of human vascular endothelial cells"Clin. Cancer Res.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] S.Hiscox et al.: "Inhibition of HGF/SF-induced breast cancer cell matility and invasion by the HGF/SF variant,NK4"Breast Cancer Res. & Treat.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] M.Nakano et al.: "Hepatocyte growth factor is essential for amelioration of hyperglycemia in strepto zotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts"Transplantation. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] T.Yamada et al.: "Enhanced expression of hepatocyte growth factor by pulmonary ischemia reperfusion injiury in the rat"Am. J. Resp. Crit Care Med.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] S.Mizuno et al.: "Reciprocal balance between HGF and TGF-β a key determinant for pathological phenotypes in chronic renal disease"Kidney Intern.. 57. 937-948 (2000)

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      1999 Annual Research Report
  • [Publications] C.Parr et al.: "NK4,a new HGF/SF variant,is an antagonist to the influence of HGF/SF on the matility and invasion of colon cancer cells"Intern. Cancer. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] 中村敏一: "新しい腫瘍血管新生抑制物質 - malognostatin (NK4)"細胞工学. 18. 223-225 (1999)

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      1999 Annual Research Report
  • [Publications] 久場敬司、松本邦夫、中村敏一: "HGF による血管新生とその分子内クリングル断片 (NK4) による腫瘍血管新生阻害"実験医学. 17. 734-740 (1999)

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      1999 Annual Research Report
  • [Publications] 水野信哉、中村敏一: "HGF による急性および慢性腎不全の治療"腎と透析. 46. 494-498 (1999)

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      1999 Annual Research Report
  • [Publications] 久場敬司、中村敏一: "HGF と癌の浸潤・転移"Surgery Frontier6(No2):27-38. 6. 27-38 (1999)

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      1999 Annual Research Report
  • [Publications] 小清水右一、中村敏一: "HGF - 肝細胞癌に対する HGF の抗腫瘍作用"血液・免疫・腫瘍. 4. 40-45 (1999)

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      1999 Annual Research Report
  • [Publications] 中村隆弘、中村敏一: "肝再生の分子機序"別冊:医学のあゆみ、消火器疾患. 2. 68-73 (1999)

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      1999 Annual Research Report
  • [Publications] 久場敬司、中村敏一: "医学研究その15:血管新生 (Angiogenesis)"The Lung. 7. 94-99 (1999)

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      1999 Annual Research Report
  • [Publications] 水野信哉、中村敏一: "肝細胞増殖因子による腎再生"最新医学. 54. 59-69 (1999)

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      1999 Annual Research Report
  • [Publications] 角 智行、中村敏一: "細胞遊走における増殖因子の役割"医学のあゆみ. 191. 137-142 (1999)

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      1999 Annual Research Report
  • [Publications] 水野信哉、中村敏一: "肝再生と HGF"現代医療. 31. 69-78 (1999)

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      1999 Annual Research Report
  • [Publications] 松本邦夫、中村敏一: "HGF の臨床応用に向けて"Medical Academy News. 720/721. 12-12 (1999)

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      1999 Annual Research Report
  • [Publications] 船越 洋、中村敏一: "肝細胞増殖因子 (HGF) の検査値と各種疾患"日本臨牀. 37. 821-826 (1999)

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      1999 Annual Research Report
  • [Publications] 小清水右一、中村敏一: "形質転換成長因子 (TGF)"日本 臨牀. 37. 802-804 (1999)

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      1999 Annual Research Report
  • [Publications] 松本邦夫、中村敏一: "肝細胞の培養法"細胞生物学実験法. 1. 27-47 (1999)

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      1999 Annual Research Report
  • [Publications] 松本邦夫、中村敏一: "タンパク質の分析法"分子生物学プロトコール 改訂2版. 11章. 269-284 (1999)

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      1999 Annual Research Report
  • [Publications] 水野信哉、中村敏一: "HGF による腎疾患の治療"Annual Review 腎臓 2000. XII. 233-240 (2000)

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      1999 Annual Research Report
  • [Publications] 松本邦夫: "HGF による再生医学の実践"実験医学. 18. 424-430 (2000)

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      1999 Annual Research Report
  • [Publications] 松本邦夫、中村敏一: "HGF の分子内断片 NK4 による血管新生阻害と制癌"Molecular Medicine. 37. 276-282 (2000)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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