| Project/Area Number |
11680740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Shimane Medical University |
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Principal Investigator |
YASUI Yukihiko Shimane Med. Univ., Dept. of Anatomy, Professor, 医学部, 教授 (30174501)
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| Co-Investigator(Kenkyū-buntansha) |
TSUMORI Toshiko Shimane Med. Univ., Anatomy, Assistant Prof., 医学部, 助手 (30217377)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Limbic system / Amygadaloid body / Orofacial movement / Motor trigeminal nucleus / Facial nucleus / Premotor neuron / Reticular formation / Emotion / 小細胞性網様体 |
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| Research Abstract |
We have been studied on the control pathways from the central amygdaloid nucleus (ACe) to the motor trigeminal and facial nuclei. We examined the distribution of efferent fibers from the ACe and that of premotor neurons projecting directly to the motor trigeminal or facial nucleus, using a combined anterograde and retrograde tracing method with biotinylated dextranamine and cholera toxin B subunit.
As a result, the good overlapping distribution of the ACe fibers and premotor neurons was found mainly in the parvicellular reticular formation of the pons and medulla oblongata, additionally in the nucleus of the solitary tract and the sensory trigemunal nuclei. Whithin the parvicellular reticular formation, the bouton-like varicosities of the ACe fibers were often observed to be closely apposed to the somata and dendrites of the premotor neurons. In the electron microscopic level, it was revealed that the ACe fibers made asymmetrical synapses predominantly with dendrites and partly with somata of the premotor neurons. Furthermore, synaptic dense bodies were often observed in the active zone of the axo-dendritic synapses.
Thus, the present data suggest that the ACe may take part in the control of emotional orofacial movements through its descending projections to the motor trigeminal and facial nuclei via the parvicellular reticular neurons.
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