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Gene therapy against model mice with neurodegenerative disorder

Research Project

Project/Area Number 11680800
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

OGAWARA Midori  Tokyo Metropolitan Institute of Gerontology, Department of Molecular Genetics, Assistant, 分子遺伝学部門, 研究助手 (60100111)

Co-Investigator(Kenkyū-buntansha) 白澤 卓二  財団法人 東京都老人総合研究所, 分子遺伝学部門, 室長 (80226323)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsNeurodegeneration / Gene therapy / Isoaspartic acid / PIMT / Knockout mice / Transgenic mice / Adeno virus / Alzheimer's disease / メチル転移酵素 / 培養神経細胞 / 修復効果
Research Abstract

Protein isoaspartyl methyltransferase (PIMT) has been suggested to play a role in the repair of aged proteins spontaneously incorporated with isoaspartyl residues. Thus the lack of this repair system was expected to show an abnormal accumulation of isoaspartate in the brain of knockout animals with reference to the pathological implications of protein isomerization during aging. Recently, we reported knockout mice lacking the enzymatic activity for PIMT.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Shimizu,T.et al.: "Isoaspartate formation and neurodegeneration in Alzheimer's disease"Archives of Biochemistry and Biophysics. 381. 225-234 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimizu, T., Watanabe, A., Ogawara, M., Mori, H., and Shirasawa, T.: "Isoaspartate formation and neurodegeneration in Alzheimer's disease."Arch. Biochem. Biophys.. 381. 225-234 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimizu,T. et al.: "Isoaspartate formation and neurodegeneration in Alzheimer's disease"Archives of Biochemistry and Biophysics. 381. 225-234 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tomoda T. et al.: "A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons"Neuron. 24. 833-846 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakano H. et al.: "Targeted disruption of traf5 gene causes defects in CD40- and CD27- mediated lymphocyte activation"Proc Natl Acad Sci USA. 96. 9803-9808 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yan J. et al.: "Mouse ULK2, a novel member of the UNC-51-like protein kinases : unique features of functional domains"Oncogene. 18. 5850-5859 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukuda H. et al.: "Synthesis, Aggregation,and Neurotoxicity of the Alzheimer's Abetal-42 Amyloid Peptide and Its Isoaspartyl Isomers"Bioorganic & Medicinal Chemistry Letters. 9. 953-956 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto A. et al.: "Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy"J Neurosci. 18. 2063-2074 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Smith, C. D. et al.: "Crystallization and preliminary cryogenic X-ray diffraction analyses of protein L-isoaspartyl O-methyltransferase from human fetal brain"Proteins. 28. 457-460 (1997)

    • Related Report
      1999 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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