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Neural mechanisms of top-down control in primate prefrontal cortex : from single neuron to functional brain imaging

Research Project

Project/Area Number 11680803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionThe University of Tokyo

Principal Investigator

HASEGAWA Isao  The University of Tokyo, Graduate School of Medicine, Department of Physiology, 大学院・医学系研究科, 講師 (60282620)

Co-Investigator(Kenkyū-buntansha) TOMITA Hyoe  The University of Tokyo, Graduate School of Medicine, Department of Physiology, 大学院・医学系研究科, 助手 (50292727)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsmacaque / prefrontal cortex / single unit recording / functional MRI / 眼球運動 / 側頭葉 / 記憶検索 / スプリットブレイン / 体性感覚野
Research Abstract

It is important to understand the brain mechanisms underlying memory and cognition from cellular events to individual behaviors. Toward this objective, the present project aims to investigate the mechanisms of top-down memory control (Hasegawa et al Science 281, 814-818, 1998) combining (1)single cell recordings of neuronal activity and (2) functional magnetic resonance imaging (fMRl), using animal models with macaque monkeys.
(1) We conducted single unit recording from inferior temporal cortex in partial split-brain monkeys. We have shown that activity of inferior temporal neurons during memory recall can be induced by top-down signals from prefrontal cortex in the absence of bottom-up signals (Nature 401, 699-703. 1999). We also have recorded activity of prefrontal neurons during oculomotor tasks, and found that prefrontal neurons can code spatial memory information to guide behavior, even when non-spatial cues instruct switch of the target location (Soc. Neurosci. Abstr. 26, 404. 2, 2000).
(2) We have built fMRl systems for scanning macaque monkeys using 1.5T and 4.7T magnets. With 1.5T magnet, we have shown the feasibility of fMRl to reveal somatotopy in primary and second somatosensory cortex (Eur. J. Neurosci. 11, 4451-56, 1999). With 4.7T magnet we have been making high-contrast activation maps of cortical oculomor areas (Soc. Neurosci. Abstr. 27, 345. 12, 2001). In future, we plan to make functional activation maps with cognitive memory tasks, with the aid of which we will perform functional inactivation and single unit experiments

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Hasegawa I., Miyashita Y.: "Categorizing the world : expert neurons look into key features"Nature Neurosci.. 5. 90-91 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama M., Hasegawa I., Miyashita Y.: "Neural basis of object recognition"in Encyclopedia of Cognitive Science, Macmillan Ltd.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I. et al.: "Event-related functional magnetic resonance imaging in awake macaque monkeys performing coulometer tasks"Soc. Neurosci. Abstr.. 27. 345.12 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I.: "Neural mechanisms of memory retrieval : role of the prefrontal cortex"Rev. Neurosci.. 11. 113-125 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima T., Hasegawa I., Miyashita Y.: "Modulation of neuronal activity in macaque dorsal periarcuate cortex by external signals to change behavioral target"Soc. Neurosci. Abstr.. 26. 404.2 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima T., Hasegawa I., Miyashita Y.: "Modulation of neuronal activity in macaque prefrontal cortex by shifts of saccade target"Neurosci. Res.. 24. S55 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I., Hayashi T., Miyashita Y.: "Memory retrieval under the control of the prefrontal cortex"Ann. Med.. 31. 380-387 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi T., Konishi S., Hasegawa I., Miyashita Y.: "Mapping of somato sensory cortices with functional magnetic resonance imaging in macaque monkeys"Eur. J. Neurosci.. 11. 4451-4456 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H., Ohbayashi M., Nakahara K, Hasegawa I., Miyashita Y.: "Top-down signal from the prefrontal cortex in executive control of memory retrieval"Nature. 401. 699-703 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H. et al.: "Neural response in posterior split-brain monkeys performing visual stimulus-stimulus association task"Soc. Neurosci. Abstr.. 25. 316.8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H. et al.: "Functional fronto-temporal connectivity in posterior split-brain monkeys"Neurosci. Res.. 23. S254 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi T. et al.: "Mapping of somato sensory cortices with functional magnetic resonance imaging in macaque monkeys"Neurosci. Res.. 23. S296 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I, and Miyashita Y: "Categorizing the world : expert neurons look into key features"Nature Neurosci. 5. 90-91 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama M, Hasegawa I, and Miyashita Y: "Neural Basis of object recognition"in Encycopedia of Cognitive Science. Macmillan Reference Ltd. (in Press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I, Koyama M, Nakahara K, Morita M, Hayashi T, Fukushima T, and Miyashita Y: "Event-related functional magnetic resonance imaging in awake macaque monkeys performing oculomotor tasks"Soc. Neurosci. Abstr. 27. 345.12 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I: "Neural mechanisms of memory retrieval : role of the prefrontal cortex"Rev. Neurosci. 11. 113-125 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima T, Hasegawa I, and Miyashita Y: "Modulation of neuronal activity in macaque dorsal periarcuate cortex by external signals to change behavioral target"Soc. Neurosci. Abstr. 26. 404.2 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima T, Hasegawa I, and Miyashita Y: "Modulation of neuronal activity in macaque prefrontal cortex by shifts of saccade target"Neurosci. Res. 24. S55 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I, Hayashi T, and Miyashita Y: "Memory retrieval under the control of the prefrontal cortex"Ann. Med. 31. 380-387 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi T, Konishi S, Hasegawa I, and Miyashita Y: "Mapping of somatosensory cortices with functional magnetic resonance imaging in macaque monkeys"Eur. J. Neurosci. 11. 4451-4456 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H, Ohbayashi M, Nakahara K, Hasegawa I, and Miyashita Y: "Top-down signal from the prefrontal cortex in executive control of memory retrieval"Nature. 401. 699-703 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H, Ohbayashi M, Nakahara K, Hasegawa I, and Miyashita Y: "Neural response in posterior split-brain monkeys performing visual stimulus-stimulus association task"Soc. Neurosci. Abstr. 25. 316-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomita H, Ohbayashi M, Nakahara K, Hasegawa I, and Miyashita Y: "Functional front-temporal connectivity in post*or-split-brain monkeys"Neurosci. Res. 23. S254 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi T, Konishi S, Hasegawa I, and Miyashita Y: "Mapping of somatosensory cortices with functional magnetic resonance imaging in macaque monkeys"Neurosci. Res. 23. S296 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa I., Miyashita Y.: "Categorizing the world : expert neurons lock into key features"Nature Neuroscience. 5. 90-91 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koyama M., Hasegawa I., Miyashita Y.: "Neural basis of object recognition"Eneyclopedia of Cognitive Science. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hasegawa I, Koyama M., Nakahara K., Morita M., Hayashi T., Fukushima T., Miyashita Y.: "Event-related functional magnetic resonance imaging in awake macaque monkeys performing oculomotor tasks"Society for Neuroscience Abstract. 27. 345-412 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hasegawa I.: "Netural mechanisms of memory retrieval role of the prefrontal cortex"Reviews in the Neurosciences. 11. 113-125 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukushima T.,Hasegawa I.Miyashita Y.: "Modulation of neuronal activities in macaque dorsal periarcuate area by target shift cues."Society for Neuroscience Abstract. 26. 404.2 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukushima T.,Hasegawa I.Miyashita Y.: "Modulation of neuronal activity in macaque prefrontal cortex by shifts of the saccade target."Neuroscience Research Supplement. 24. S55 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koyama M.,Hasegawa I.,Miyashita Y.: "Neural basis of object recognition"Encyclopedia of Cognitive Science. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hasegawa I.Hayashi T.Miyashita Y.: "Memory retrieval under the control of the prefrontal cortex"Annals of Medicine. 31. 380-387 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hasegawa I.: "Neural mechanisms of memory retrieval : role of the prefrontal cortex"Reviews in the Neurosciences. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomita H.Ohbayashi M.Nakahara K.Hasegawa I.Miyashita Y.: "Top-down signal from the prefrontal cortex in executive control of memony retrieval"Nature. 401. 699-703 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayashi T.Konishi S.Hasegawa I.Miyashita Y.: "Mapping of somatosensory cortices with functional magnetic resonance imaging in macaque monkeys"European jounnal of Neuroscience. 11. 4451-4456 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomita H.Ohbayashi M.Nakahara K.Hasegawa I.Miyashita Y.: "Neural response in posterion split-brain monkeys performing visual stimulus-stimulus association task"Society for Neuroscience Abstract. 25. 789-789 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayashi T.Konishi S.Hasegawa I.Miyashita Y.: "Mapping of somatosensory cortices with functional magnetic resonance imaging in macaque monkeys"Neuroscience Research Supplement. 23. 296-296 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomita H.Ohbayashi M.Nakahara K.Hasegawa I.Miyashita Y.: "Functional fronto-temporal connectivity in posterion -split-brain monkeys"Neuroscience Reseanch Supplement. 23. 254-254 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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