| Project/Area Number |
11680830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TOHYAMA Harukazu Hokkaido Univ., Grad. School of Medicine, Lec., 大学院・医学研究科, 講師 (60301884)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Kazunori Hokkaido Univ., Grad. School of Medicine, Prof., 大学院・医学研究科, 教授 (20166507)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Stress-enhancement / Stress-deprivation / Patellar Tendon / Biomechanics / Tendon Autograft / Mechanical Properties / Tensile Force |
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| Research Abstract |
1. Effects of Inhibition Extrinsic Cell Infiltration on Patellar Tendons After Intrinsic Fibroblast Necrosis : We analyzed the effect of inhibition of extrinsic cell infiltration on mechanical properties of the patellar tendon after intrinsic fibroblast necrosis using 72 rabbits. As a result, the inhibition of extrinsic cell infiltration prohibited the reduction in mechanical properties of the patellar tendon that occurred following intrinsic cell necrosis.
2. Effects of Stress Enhancement on the Mechanical Properties of in situ Frozen Patellar Tendons : A biomechanical study was conducted to clarify the effect of stress enhancement on the mechanical properties of the in situ frozen-thawed patellar tendons using 30 rabbits. As a result, excessively high stress reduced the mechanical properties of the frozen-thawed patellar tendon.
3. Effects of the Presence Intrinsic Fibroblasts or Extrinsic Infiltrating Cells on the Mechanical Properties of the Extracellular Matrix in the Stress-enhance
… More
d Patellar Tendon A study was conducted to determine the effect of the presence of intrinsic fibroblasts or extrinsic infiltrating cells on the extracellular matrix of the stress-enhanced patellar tendon using 48 rabbits. As a result, intrinsic fibroblasts prohibited detrimental effects of stress enhancement on mechanical properties of the patellar tendon and extrinsic infiltrating cells increased the cross-sectional area of the patellar tendon.
4. Biomechanical Comparison between Effects of Stress-enhancement and Stress-deprivation on Mechanical Properties of Frozen-thawed Paterllar Tendons : We compared effects of stress-enhancement on mechanical properties of the frozen-thawed patellar tendon to those of stress-deprivation in a rabbit model. As results, stress-deprivation rapidly deteriorated mechanical properties of the frozen-thawed patellar tendon, while stress-enhancement gradually deteriorated them.
5. Conclusions : This project has revealed that effects of stress-enhancement on mechanical properties of the frozen-thawed patellar tendon are different from those of stress-deprivation, and that biological responses of extrinsic infiltrating cells contribute to mechanisms of these effects. Less
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