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Structures, permeability and bio-compatibility of sericin hydrogel membranes

Research Project

Project/Area Number 11680837
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionShinshu University

Principal Investigator

NAGURO Masanobu  Fac.Tex.sci.& Tech., Professor, 繊維学部, 教授 (70021178)

Co-Investigator(Kenkyū-buntansha) MINOURA Norihiko  National Inst.Mat.& Chem.Res., Research Leader, 物質工学工業研究所, 室長
GOTOH Yasuo  Fac.Tex.Sci.& Tech., Assistant, 繊維学部, 助手 (60262698)
OHKOSHI Yutaka  Fac.Tex.sci.& Tech., Associate Prof., 繊維学部, 助教授 (40185236)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Keywordssericin / hydrogel / high water content / chemical cross-link / dimethylolurea / citric acid / poly (vinyl alcohol)
Research Abstract

It is recently clarified that sericin is useful as excellent functional materials. However sericin is very weak and there have not existed any practical materials in all over the world.
The purpose of this project is to prepare a tough and practical sericin membrane by chemical cross-linking, and to study the relation between structure and physical property of the membrane, and to apply the membranes as a biomaterial. The membrane were prepared by cross-linking sericin and small amount of poly (vinyl alcohol) aqueous solution by dimethylolurea (DMU) and citric acid (CA) as cross-linking agents, and blending to sericin with poly (vinyl alcohol).
The chemical cross-link increases with increasing DMU and CA even the extraction of the excess DMU and CA.Water content is lowered to 0.25 mole ratio of the cross-linking agent, and it increases over 0.5 again. Young's modulus shows the tendency which is reverse to the result of water content. Young's modulus of the cross-linked membranes by CA is higher than that of the membranes cross-linked by DMU.
It is obvious that every hydrogel membrane prepared by blending does not dissolve in water below 40℃ and the hydrogel membranes show the tough and rubber-like properties up to about 40 wt % sericin content, because the sericin molecules bind with the amorphous PVA molecules by intermolecular hydrogen bonds. Oxygen permeability coefficients of hydrogel membranes are near the case of pure water. The contact angle of water on the surface of membranes was about 80°. These results means that these membranes are probably useful as the biomaterial such as a damage covering material and cell scaffolding material.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Masanobu Nagura: "Structure s and physical properties of cross-linked sericin membranes"J.Insect Biotechnology and Sericology. 1巻(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Nagura, R.Ohnishi, Y.Gotoh, and Y.Ohkoshi: "Structures and physical properties of cross-linked sericin Membranes"J.Insect Biotechnology and Sericology. Vol.1(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masanobu Nagura: "Structures and physical properties of cross-linked sericin membranes"J.Insect Biotechnology and Sericology. 1巻(印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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