| Project/Area Number |
11691120
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
人類学(含生理人類学)
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| Research Institution | The Graduate University for Advanced Studies(Sokendai) |
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Principal Investigator |
HORAI Satoshi The Graduate University for Advanced Studies(Sokendai), Department of Biosystems Sciences Professor, 先導科学研究科, 教授 (40126157)
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| Co-Investigator(Kenkyū-buntansha) |
YUASA Isao Tottori University Faculty of Medicine Department of Legal Medicine, Lecturer, 医学部, 講師 (00093633)
TOKUNAGA Katsushi University of Tokyo Graduate School of Medicine Department of Human Genetics, Professor, 大学院・医学系研究科, 教授 (40163977)
高畑 尚之 総合研究大学院大学, 先導科学研究科, 教授 (30124217)
颯田 葉子 総合研究大学院大学, 先導科学研究科, 助教授 (20222010)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥17,430,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2001: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2000: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1999: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Ethnic minorities / DNA polymorphic markers / Cell line / Mitochondrial DNA / HLA gene / Blood Type / Y chromosomal DNA / Microsatellite DNA / ミトコンドリア多型 |
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| Research Abstract |
Yunnan province (situated in southwest China) has more than 20 ethnic groups, who still keep their original cultural heritage and practices. At present, we have little knowledge of their genetic origins and the relationships among them. On the other hand, it has been well known to be many ethnic minorities inhabiting various geographical regions of Thailand. Notably, some ethnic groups in Thailand have the same ethnic names as those in Yunnan. However, it remains unclear whether such groups in Yunnan and Thailand share common genetic background.
In this research project, (1) we examined DNA polymorphisms on various genomic regions (e.g., mitochondrial DNA, HLA gene, blood types, Y chromosomal DNA, autosomal microsatellite DNA and β-globin gene) in several ethnic groups from Yunnan and Thailand. (2) By analyzing the obtained data for the ethnic minorities together with published data for other Asian populations (such as Han Chinese, Thai, and Japanese), we inferred the phylogenetic positions of the ethnic groups in the entire Asian populations. (3) We found that some ethnic groups in Yunnan and Thailand were closely related to each other, suggestive of past human migration between southern part of China and southeast Asia. (4) By treatment with Epstein-Barr virus, we established immortalized cell lines from peripheral blood-derived lymphocytes which were collected from the ethnic minorities.
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