| Project/Area Number |
11691202
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Digestive surgery
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| Research Institution | TEIKYO UNIVERSITY (2000-2001)
The University of Tokyo (1999) |
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Principal Investigator |
YANAGIE Hironobu Teikyo University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (30212278)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Yasutaka University of Tokyo, Institute of Medical Science, Research Associate, 医科学研究所, 助手 (40163422)
OGURA Koichi Nihon University, College of Industrial Technology, Professor, 生産工学部, 教授 (60059681)
KOBAYASHI Hisao Rikkyo University, Institute for Atomic Energy, Professor, 原子力研究所, 教授 (10062605)
MASUNAGA Shin-ichiro Kyoto University, Research Reactor Institute, Associate Professor, 原子炉実験所, 助教授 (80238914)
ONO Koji Kyoto University, Research Reactor Institute, Professor, 原子炉実験所, 教授 (90122407)
江里口 正純 東京大学, 医科学研究所, 助教授 (10114406)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥46,380,000 (Direct Cost: ¥42,300,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2001: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2000: ¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 1999: ¥15,100,000 (Direct Cost: ¥15,100,000)
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| Keywords | Boron Neutron Capture Therapy(BNCT) / Reactor for Mcdical Use / Thermal neutron / Neutron Capture Radiography / Intelligent Targeting System / Stealth Liposome / Boron Compound / Pancreas Cancer, Hepatic Cancer, Breast Cancer / 中性子捕捉療法 / BSH / BPA / 熱外中性子 / ドラッグデリバリーシステム / ステルスリポソーム |
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| Research Abstract |
We perform the international collaboration for appication of Boron Neutron capture Therapy(BNCT) to intraoperative irradiation thrapy of cancer.
(1) We prepare a polyethylene-glycol (PEG) binding liposome entrapped ^<10>B compound for the delivery system. After thermal neutron irradiation of mice injected with ^<10>B-bare liposome or ^<10>B-PEG-liposome, AsPC-1 tumour growth was suppressed relative to controls. Injection of ^<10>B-PEG-liposome caused the greatest tumour suppression with thermal neutron irradiation in vivo.
(2) We performed neutron capture autoradiography(NCAR) using CR-39 plastic track detectors. The CR-39 detectors attached with samples were exposed to thermal neutrons or cold neutrons at Rikkyo University, PSI, Institute of Jozef Stefan or Sakley Institute. We can increase the accumulation of ^<10>B atoms in the tumor tissues by PEG-liposome, which increase the retension in the blood flow and escape the phagocytosis by RES.
(3) BNCT were performed to 64 brain tumor patients consisting of glioblastoma maltiforme(GBM) and anaplastic astrocytoma at Kyoto University Reactor. BNCT was superior to the standard therapy on survival rate in Japan. Two-year survival rates were superior to the outcome by standard treatment.
(4) The BNCT group of pavia University, Italy, was performed the BNCT for isolated liver with multiple metastasis of colon cancer after perfusion of BPA. After BNCT the liver was reconnected to the patient. The outcome of the patient is still good in 7 months after operation.
(5) Eighteen patients of GBM was performed the BNCT after drip infusion of BPA at reactor of Helsinki University, Finland. The average planning target dose of neutron and normal brain dose of neutron was 30〜61Gy and 3〜6 Gy, respectively. The total 1-year survival rate was 61%.
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