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Search for Indonesian Marine Life as Medicinal Resource (2)

Research Project

Project/Area Number 11691208
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

KOBAYASHI Motomasa  Faculty of Pharmaceutical Sciences, Osaka University, Professor, 薬学研究科, 教授 (40116033)

Co-Investigator(Kenkyū-buntansha) TANAKA Junichi  College of Science, University of the Ryukyus, Associate Professor, 理学部, 助教授 (20163529)
AOKI Shunji  Faculty of Pharmaceutical Sciences, Osaka University, Assistant Professor, 薬学研究科, 助手 (60252699)
HIGA Tatsuo  College of Science, University of the Ryukyus, Professor, 理学部, 教授 (10101461)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥23,470,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2001: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2000: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1999: ¥7,600,000 (Direct Cost: ¥7,600,000)
KeywordsIndonesia / Marine Invertebrate / Marine resource / Marine sponge / Biological active
Research Abstract

The sea will continue to play important roles for the future of human being not only as the source of food and energy but also for the conservation of environment. Other than these roles, the sea is also expected to provide biologically active substances, which have potential to be developed into new medicines. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakkarta and other coastal cities. Considering these situations, it is important to initiate the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters.
The present research is carried out by the project in collaboration with Pusat Penelitian dan Pengembangan Oseanologi (Res … More earch and Development Center for Oceanology)- LIPI, Indonesia and Osaka University and University of the Ryukyus, Japan. The objectives of this proposal are to conduct a joint research on medicinal potential of Indonesian marine organisms and to promote scientific exchange between Indonesia and Japan in the disciplines encompassing marine biology, natural product chemistry, and biomedical science. The Indonesian waters are known to be rich in diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms.
The survey was proceeded at the coral reef of bitung, North Sulawesi, in August, 1999, the coral reef Kendari, South Sulawesi in August, 2000, and the coral reef of Labuanbajo, Flores Island in August, 2001. Mainly sessile invertebrates such as sponges and tunicate were surveyed and collected by scuba diving. The extracts of collecting samples were subjected to the screening bioassays (e. g. antimicrobial activity, cytotoxic activity against cultured tumor cells (KB, L1210), reversal activity of multi-drug resistance in tumor cell (KV-C2, KV-CV60, and KB-3-1 cell lines), and other viological activities. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (93 results)

All Other

All Publications (93 results)

  • [Publications] M.Kobayashi: "Marine spongean cytotoxins"J. Nat. Toxins. 8. 249-258 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Myrmekiosides A and B, novel mono-O-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge"Tetrahedron. 55. 14865-14870 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Reversal of multidrug registance in human carcinoma cell line by agosteros, marine spongian sterols"Tetrahedron. 55. 13965-13972 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Doi: "The highly solvated structure of theonellapeptolide Id, a tridecapeptide lactone from the Okinawan marine sponge"Acta Cryst.. C55. 796-798 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Tanaka: "Two new cytotoxic carbonimidic dichlorides from the nudibranch Reticulidia fungia"J. Nat. Prod.. 62. 1339-1340 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.C.Roy: "Barangamide A, a new cyclic peptide from an Indonesian sponge, Theonella swinhoei"Tetrahedron Lett.. 40. 5373-5376 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Suzuki: "S1319, a novel β-adrenoceptor agonist from a marine sponge Dysidea sp."Bio. Med. chem. Lett.. 9. 1361-1364 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Suzuki: "Tracheal relaxing effects and beta (2)-adrenoceptor selectivity of S1319, a novel sponge-derived bronchodilator agent, in isolated guinea-pig tissues"Br. J. Pharm.. 128. 716-720 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Suzuki: "Tracheal relaxing effects and beta (2)-selectivity of S1319, a novel beta (2)-adrenoceptor agonist from the marine sponge Dysidea sp"Am. J. R. Crit.. 159. A394-A394 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Lembehyne A, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp"Tetrahedron. 56. 9945-9948 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Murakami: "Participation of conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide"Bioorg. Med. Chem.. 8. 1680-1690 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Murakami: "Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A"Bio. Med. chem. Lett.. 10. 1823-1826 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Miyamoto: "Xestospongin C, a selective and membrane-permeable inhibitor of IP3 receptor, attenuates the positive inotropic effect of α-adrenergic stimulation"Br. J. Pharmacol.. 130. 650-654 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Melophline A and B, novel tetramic acids reversing the phenotype of ras-transformed cells, from the marine sponge Melophlus sarassinorum"Tetrahedron. 56. 1833-1836 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Doi: "Amphipathic structure of theonellapeptolide-Id, a hydrophobic tridecapeptide lactone from the Okinawan marine sponge Theonella swinhoei"Biopolymers. 54. 27-34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I.Erdogan: "Two cyclic hexapeptides from the marine sponge Theonella cupola"FABAD Farm. Bilimler Derg.. 25. 7-10 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.C.Roy: "New cyclic peptides from the Indonesian sponge Theonella swinhoei"Tetrahedron. 56. 9079-9092 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Suzuki: "The effects of S1319, a novel marine sponge-derived beta(2)-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells"Inflamm. Res.. 49. 86-94 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Aniya: "Dimerumic acid as an antioxidant of the mold, Monascus anka"Free Rad. 28. 999-1004 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.K.H.Ang: "In vivo antimalarial activity of the beta-carboline alkaloid manzamine A"Antim. Ag. Ch.. 44. 1645-1649 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Higa: "Toxins associated with medicinal and edible seaweeds"J. Tox. Tox. Rev.. 19. 119-137 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Kuniyoshi: "3-Bromobarekoxide, an unusual diterpene from Laurencia luzonensis"J. Chem. Soc. Chem. Commun.. 1155-1156 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I.Erdogan: "Tryptophol, a plant auxin isolated from the marine sponge Ircinia spinulosa"Bioch. Syst.. 28. 793-794 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the goronian Briareum excavatum"Tetrahedron. 57. 8951-8957 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "Facile construction of 6-carbomethoxymethyl-3-methoxy-1,2-dioxane, a core structure of spongean anti-malarial peroxides"Tetrahedron Lett.. 42. 7281-7285 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Novel neuronal nitric synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta"Chem. Pharm. Bull.. 49. 1372-1374 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "Synthesisi of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide"Tetrahedron. 57. 4323-4336 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene"Biochem. Biophys. Res. Commun.. 282. 426-431 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Molecular modeling of 5-deacetylaltohyrtin A, a spogean cytotoxic"Tetrahedron. 57. 2289-2292 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "Total synthesis of Iembehyne A, a neuritogenic spongean polyacetylene"Tetrahedron Lett.. 41. 1941-1943 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "Participation of the β-hydroxyketone part for potent cytotoxicity of callystatin A, a spongean polyketide"Bioorg. Med. Chem.. 9. 57-67 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Lembehyne A, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell"Biochem. Biophys. Res. Commun.. 289. 558-563 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Tanaka: "Cacofurans A and B. New furanoditerpenes from a marine sponge"J. Nat. Prod.. 64. 1468-1470 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Musman: "New sesquiterpene carbonimidic dichlorides and related compounds from the sponge Stylotella aurantium"J. Nat. Prod.. 64. 111-113 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Higa: "New Trends in Natural Products Chemistry"Harwood Academic Publishers, Amsterdam. 109-120 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Kobayashi: "Drugs from the sea"Basel, Karger. 46-58 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.K.Chithra: "The Biology of Ascidians"Springer Verlag, Tokyo. 341-354 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kobayashi, I. Kitagawa: "Marine spongean cytotoxins"J. Nat Toxins. 8. 249-258 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Aoki, K. Higuchi, N. Murakami, and M. kobayashi: "Myrmekiosides A and B, novel mono-O-Alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of Myrmekioderma sp"Tetrahedron. 55. 14865-14870 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Aoki, A. Setiawan, Y. Yoshioka, K, Higuchi, R. Fudetani, Z-S. Chen, T. Sumizawa, S. Akiyama, and M. Kobayashi: "Reversal of Multidrug registance in human carcinoma cell line by agosterols, marine spongian sterols"tetrahedron. 55. 13965-13972 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Doi, T. Ishida, M. kobayashi, J. R. Dechamps and J. L. Flippen-Anderson: "The highly solvated structure of theonellapeptlide Id, a tridecapeptide lactone from the Okinawan marine sponge Theanella swinhoei"Acta Cryst.. C55. 796-798 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Tanaka, and T. Higa: "Two new cytotoxic cabonimidic dichlorides from the nudibranch Reticulidia fungia"J. Nat. Prod.. 62. 1339-1340 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. C. Roy, I. I. Ohtani, J. Tanaka, T. Higa, and R. Satari: "Barangamide A, a new cyclic poptide From an indenesian sponge"Theonella swinhoei Tetrahedron Lett.. 40. 5373-5376 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Suzuki, K. Shindo, A. Ueno, T. Miura, M. Takei, M; sakakibara, H. Fukuyamachi , J. Tanaka, and T. Higa: "S1319, a novel β-adrenoceptor agonist from a marine sponge Dysidea sp"Bio. Med. Chem. Lett.. 9. 1361-1364 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Suzuki, A. Ueno, M. Takei, K. Sindo, T. miura, M. Sakakibara, T. Higa, and H. Fukamachi: "Tracheal relaxing effects and beta (2)-adrenoceptor selectivity of S1319, a novel sponge-derived bronchodilator agent, in isolated guinea-pig tissues"Br. J. Pharm.. 128. 716-720 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Suzuki, T. Miura, A. Ueno, K. Shindo, M. Takei, H. Fukamachi, and T. Higa: "Tracheal relaxing effects and beta (2)-selectively of S1319, a novel beta (2)-adrenoceptor agonist from the marine sponge Dysidea sp"Am. J. R. crit.. 159. A394-A394 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Aoki, K. Matsui, K. Tanaka, R. Satari and M. Kobayashi: "Lembehyne A, a novel neuritogenic polycetylene, from a marine sponge of Haliclona sp"Tetrahedron. 56. 9945-9948 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Murakami, M. Sugimoto, T. Nakajima, M. Kawanishi, Y. Tsutsui, and M. Kobayashi: "Participation of conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide"Bioorg. Med. Chem.. 8. 1680-1690 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Murakami, W. Wang, S. Tamura, and M. Kobayashi: "Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A"Bioorg. & Med. Chem. Lett.. 10. 1823-1826 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Miyamoto, M. Izumi, M. Hori, M. Kobayashi, H. Ozaki, and H. Karaki: "Xestospongin C, a selective and membrane-permeable inhibitor of IP3 receptor, attenuates the positive inotropic effect of α-adrenergic stimulation in guinea-pig papilllary muscle"Br. J. Phamacol.. 130. 650-654 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Aoki, K. Higuchi, Y. Ye, R. Satari, and M. Kobayashi: "Melophlins A and B, novel tetramic acids reversing the phenotype of ras-transformed cells, from the marine sponge Melophlus sarassinorum"Tetrahedron. 56. 1833-1836 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Doi, T. Ishida, M. Kobayashi, Y. Katsuya, Y. Mezaki, M. Sasaki, A. Terashima, T. Taniguchi, and C. Tanaka: "Amphipathic structure of theonellapeptolide-Id, a hydrophobic tridecapeptide lactone from the Okinawan marine sponge Thenella swinhoei"Biopolymers. 54. 27-34 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I. Erdogan, J. Tanaka, and T. Higa: "Two cyclic hexapeptides from the marine sponge Theonella cupola"FABAD Farm. Bilimler Derg.. 25. 7-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M C Roy, I. I. Ohtani,T. Ichiba, J. Tanaka, R. Satan, and T. Higa: "New cyclic peptides from the Indonesian sponge Theonella swinhoei"Tetrahedron. 56. 9079-9092 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Suzuki, A. Ueno. M.Takei. K. Shindo. T. Higa. and H. Fukamachi: "The effects of S1319, a novel marine sponge-derived beta(2)-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells"Inflamm. Res.. 49. 86-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y Aniya I. I.Ohtani,T. Higa,C. Miyagi, H. Gibo,M. Shimabukuro, H. Nakamsh., and J Taira: "Dimerumic acid as an antioxidant of the mold, Monascus anka"Free Rad. B.. 28. 999-1004 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. K. H. Ang, M. J. Holmes, T. Higa, M. T. Hamann, and U. A. K. Kara: "In vivo antimalanalactivity of the beta-carboline alkaloid manzamine A"Antim. Ag. Ch.. 44. 1645-1649 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Higa, and M. Kuniyoshi: "Toxins associated with medicinal and edible seaweeds"J. Tox. Tox. Rev.. 19. 119-137 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kuniyoshi, M. S. Marma,T. Higa, G. Bemardinelli, and C. W. Jefford: "3-Bromobarekoxide, an unusual diterpene from Laurencia luzonensis"J. Chem. Soc. Chem. Commun.. 1155-1156 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I. Erdogan, B. Sener, and T. Higa: "Tryptophol, a plant auxin isolated from the marine sponge Ircinia spinulosa"Bioch. Syst.. 28. 793-794 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Aoki M Okano, K. Matsui,T. Itoh, R. Satari, S. Akiyama, and M. Kobayashi: "Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the gorgonian Briareum excavatum"Tetrahedron. 57. 8951-8957 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M Murakami, M. Kawanishi, S. Itagaki. T. Horii, and M. Kobayashi: "Facile constructs of 6-carbomethoxymethyl-3-methoxy- 1 ,2-dioxane, a core structure of spongean anti-malarial peroxides"Tetrahedron Lett.. 42. 7281-7285 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Aoki Y Ye K Higuchi, A. Takashima, Y. Tanaka, I. Kitagawa, and M. Kobayashi: "Novel neuronal nitric synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta"Chem. Pharm. Bull.. 49. 1372-1374 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N Murakami, S. Tamura, W.Wang, T. Takagi, and M. Kobayashi: "Synthesisi of stable analogs m blood and conformational analysis of arenastatin A , a potent cytotoxic spongean depsipeptide"Tetrahedron. 57. 4323-4336 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Aoki, K Higuchi, N. Isozumi, K. Matsui, Y. Miyamoto, N. Itoh, K. Tanaka, and M. Kobayashi: "Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene"Biochem. Biophys. Res. Commun.. 282. 426-431 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Aoki N. Nemoto, Y. Kobayashi, M. Kobayashi, and 1. Kitagawa: "Molecular modeling of 5- deacetylaltohyrtin A, a spogean cytotoxic macrolide"Tetrahedron. 57. 2289-2292 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Murakami, T. Nakajima, and M. Kobayashi: "Total synthesis of lembehyne A, a neuritogenic spongean polyacetylene"Tetrahedron Lett.. 41. 1941-1943 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Murakami, M. Sugimoto, and M. Kobayashi: "Participation of the β-hydroxyketone part for potent cytotoxicity of callystatin A, a spongean polyketide"Bioorg. Med. Chem.. 9. 57-67 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Aoki K Matsui,T. Tanaka, W. Hong, and M. Kobayashi: "Lembehyne A, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell"Biochem. Biophys. Res. Commn.. 289. 558-563 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Tanaka, G. Marriott, and T. Higa: "Cacofurans A and B. New furanoditerpenes from a marine sponge"J. Nat. Prod.. 64. 1468-1470 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Musman, J. Tanaka, and T. Higa: "New sesquiterpene carbonimidic dichlorides and related compounds from the sponge Stylotella aurantium"J. Nat. Prod.. 64. 111-113 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kobayashi: "Search for biologically active substances from marine sponges"N. Fusetani (ed.) Drugs from the Sea, Basel, Karger. 46-58 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. K. Chithra, K. N. Rajasekharan, K. Padmakumar, J.Tanaka, and T. Higa: "Biological activity and chemistry of the compound ascidian Eusynstyela tincta"H. Sawada et al. (Ed.) The Biology of Ascidians, Springer Verlag, Tokyo. 341-354 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Higa, J. Tanaka, and L. T. Tan: "Cytotoxic macrocycles from marine sponges"Atta-ur-Rhaman (Ed.) New Trends in Natural Products. 109-120 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Aoki: "Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the gorgonian Briareum excavatum"Biochem.Biophys.Res.Commun.. 289. 558-563 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Aoki: "Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene"Biochem.Biophys.Res.Commun.. 282. 426-431 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Aoki: "Lembehyne A, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp"Tetrahedron. 56. 9945-9948 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] T Higa: "Bioactive compounds from coral reef invertebrates"Pure and Applied Chem. 73. 589-593 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Musman: "New sesquiterpene carbonimidic dichlorides and related compounds from the sponge Stylotella aurantium"J.Nat.Prod. 64. 111-113 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] J.Tanaka: "Cacofurans A and B, new furanoditerpenes from a marine sponge"J.Nat.Prod. 64. 1468-1470 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Kobayashi: "N.Fusetani(ed.)Drugs from the Sea, Basel, Karger"Search for bio1ogically active substances from marine sponges. 46-58 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.Murakami: "Synthesis of amide analogs of arenastatin A"Tetrahedron. 56. 9121-9128 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Murakami: "Participation of the conjugated diene part for potent cytotocity of callystatin A, a spongean polyketide"Bioorg.Med.Chem.. 8. 2651-2661 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Murakami: "New multidrug resistance modulators from Atractylodis Lanceae Rhizoma"Bioorg.Med.Chem.Lett.. 10. 2629-2632 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Murakami: "Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator "Bioorg.Med.Chem.Lett.. 10. 2521-2524 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Aoki: "Lembehyne A, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp."Tetrahedron. 56. 9945-9948 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.C.Roy: "New cyclic peptides from the Indonesian sponge Theonella swinhoei"Tetrahedron. 56. 9079-9092 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Aoki: "Agostereol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of spongia sp"Tetrahedron Letter. 39. 6303-6306 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Aoki: "Reversal of Multidrug Resistance in Human Carcinoma Cell Line by Agosterols, Marine Spongean Sterols"Tetrahedron. 55. 13965-13972 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Aoki: "Myrmekiosides A and B, Novel Mono-O-alkyl-diglycosylglycerols Reversing Tumor Cell Morphology of ras-Transformed Cells"Tetrahedron. 55. 14865-14870 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Kobayashi: "Marine Spongean Citotoxins"J.Natural Toxins. 8. 249-258 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] J.Tanaka: "Iheyamines,New Cytotoxic Bisindole Pigments from a Colonial Ascidian, Polycitorella sp"Tetrahedron Lett. 40. 303-306 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] J.Tanaka,: "Two New Cytotoxic Carbonimidic Dichlorides from the Nudibranch Reticulidia fungia"J.Nat.Prod. 60. 1339-1340 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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