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Anthro-genetics on Paleomongoloid in Pan-Pacific and Northland Areas

Research Project

Project/Area Number 11691226
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Human genetics
Research InstitutionAichi Cancer Center

Principal Investigator

TAJIMA Kazuo  Aichi Cancer Center, Div. of Epidemiol. & Prev., Chief., 疫学・予防部, 部長 (30150212)

Co-Investigator(Kenkyū-buntansha) CHIBA Hitoshi  Hokkaido Univ., Graduate Scho. of Med., Assistant Prof., 医学部, 講師 (70197622)
HOIRAI Satoshi  The Graduate Univ. for Advanced Studies, Prof., 先導科学研究科, 教授 (40126157)
SONODA Shunro  Kagoshima Univ., Faculty of Med., Prof., 医学部, 教授 (40036463)
SENOO Haruki  Akita Univ. Scho. of Med., Prof., 医学部, 教授 (90171355)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥18,450,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2001: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2000: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1999: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsMongoloid / Tibetan / HTLV / HBV / HLA / mt-DNA / Ethnoepidemiology / サーメ人 / 日本人 / アンデス先住民族 / ミイラ / 核DNA / モンゴロイド
Research Abstract

Human T-cell leukemia virus type 1 (HTLV-l) is spreading throughout the world with microgeographical clusters of hyperendemicity. Epidemiologic evidences on HTLV among Mongoloids in the world showed that HTLV-l is highly endemic in South Japan and in the Andes district of South America. In the other hand HTLV type 2 (HTLV-II) is broadly distributed in the whole South America except the Andes line. The HLA haplotypes of these two carriers were mutually exclusive, i.e., the HLA haplotypes of Andes HTLV-I carriers were common among Japanese while those of HTLV-II carriers were prevalent among North American Indians. This suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the genetic susceptibility to HTLV-I and HTLV-II infections. In a previous study in this program, gene fractions of proviral HTLV-I from Andean mummy aged 1500 years was detected. This observation suggested that HTLV-I may have existed at least 1000 years before aboriginal Andean migrated from the Asian Continent and settled down in the Andes.
In Tibetan populations in China, the hepatitis B virus (HBV) genotypes have not yet been studied up until now. HBV distributed in the world is classified into seven genotypes, designated as A to G, geographically separated. Since the prevalence of HBV infection in isolated Tibetan people in the east and west regions of Tibet was very high, the HBV genotypes were determined by PCR-microwell plate hybridization method using plasma DNA. We detected only genotype in Tibetan HBV This genotype C is known to be a predominant type of HBV among Asian Mongoloids, especially in Thailand and Korea These results revealed that the Tibetan villagers are not exposed by HTLV-I but highly infected with HBV, especially with genotype C. HBV and HLA gene sequences warrant further investigation in this context.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (75 results)

All Other

All Publications (75 results)

  • [Publications] Sonoda, S.: "HTLV-I/IIからみた人類"感染・炎症・免疫. 30. 35-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Li.H.C.: "The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy"Nature Med.. 5. 1428-1432 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujiyoshi, T.: "Characteristic distribution of HTLV type I and HTLV type II carriers among native ethnic groups in south America"Aids Res.Human Retroviruses. 15. 1235-1239 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohkura, S.: "Identification and phylogenetic characterization of a human T-cell leukemia virus type I isolate from a native inhabitant (Rapa Nui) of Easter Island"J.General.Virol.. 80. 1995-2001 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamashita, M.: "Molecular epidemiology of human T-cell leukemia virus type I (HTLV-1) Brazil : the predominant HTLV-1s in South America differ from HTLV-1s of Japan and Africa, as well as those of Japanese immigrants and their relatives in Brazil"Virology. 261(1). 59-69 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Dipierri, J.E.: "A seroepidemiological survey of HTLV-I/II carriers in the Puna Junena"Medicina (Buenos Aires). 59. 717-720 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishitani, A.: "Re-examination of HLA-G polymorphism in African Americans"Immunogenetics. 49(9). 808-811 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jin.F.: "Population genetic studies on nine aboriginal ethinic groups of Taiwan.I.Red cell enzyme systems"Anthropological Science. 107(3). 229-245 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, K.: "Origins of HTLV-1 in South America"Nature Med.. 6. 232-233 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sonoda, S.: "Ancient HTLV type I provirus DNA of Andean mummy"AIDS Res.Retrovirus. 16. 1753-1756 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H.: "Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol"J.Lipid.Res.. 38. 147-159 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H.: "Phenotype-genotype correlation in CD36 deficiency types I and II"Thromb.Haemost.. 84. 436-441 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Makino, M.: "Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications"J.Human Genetics. 45(2). 69-75 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, K.: "Geographical distribution of HTLV-I/II in South America"Asian Pacific J.Cancer Prev.. 1(Suppl.). 10-12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yashiki, S.: "HLA-A^*26,HLA-B^*4002,HLA-B^*4006 and HLA-B^*4801 alleles predispose to asult T cell leukemia : the limited recognition of HTLV type I tax peptide anchor motifs and epitopes to generate anti-HTLV type I tax CD8+ cytotoxic T lymphocytes"AIDS Res.Hum.Retrovirus. 17. 1047-1061 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu, K.: "β-globin gene haplotype characteristics of Colombian Amerinds in South America"Human Heredity. 51. 54-63 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhao, S.M.: "High prevalence of HBV in Tibet, China"Asian Pacific J.Cancer Prev.. 2(4). 1-6 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, A.: "Three major lineages of Asian Y choromosome : implication for the peopling of east and southeast Asia"Hum.Genet.. 110. 80-88 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Qian, Y.P.: "Mitochondrial DNA polymorphisms in Yunnan nationalities in China"J.Hum.Genet.. 46. 211-220 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chiba.H.: "CD36 deficiency and insulin resistance"Lancet. 9277. 243-244 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H.: "Metabolic changes in human CD36 deficiency displayed by glucose loading"Thromb Haemost. 86. 995-999 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsubara, M.: "Decreased longevity in Japanese men associated with low-molecular-weight apolipoprotein(a) phenotypes"Annal.Clin.Biochem.. 38. 120-123 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Senoo, H.: "Transport and storage of vitamin A in arctic animals"Cells Hepatic Sinusoid. 8. 207-209 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nunez, L.: "Supplement Book of Ethnoepidermiological Comparison of Andeans and Japanese"Universidad Catolica del Norte, Chile. 124 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Li, H.C. et al: "The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy"Nature Med.. 5. 1428-1432 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujiyoshi, T. et al: "Characteristics distribution of HTLV type I and HTLV type II carriers among native ethnic groups in South America. Aids Res."Human Retroviruses. 15. 1235-1239 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohkura, S. et al: "Identification and phylogenetic characterization of a human T-cell leukemia virus type I isolate from a native inhabitrant (Rapa Nui) of Easter Island"J. Gedneral. Virol.. 80. 1995-2001 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamashita, M. et al: "Molecular epidemiology of human T-cell leukaemia virus type (HTLV-1) Brazil : the predominant HTLV-1s in south America differ from HTLV-1s of Japan and Africa, as well as those of Japoanese immilgrants and their relatives in Brazil"Virology. 261(1). 59-69 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Dipierri, J.E. et al: "A seroepidemiological survey of HTLV-I/II carriers in the Puna Junena"Medicina (buenos Aires). 59. 717-720 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishitani, A. et al: "Re-examination of HLA-G polymorphism in Africa Americans"Immunoogenetics. 49(9). 808-811 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jin, F. et al: "Population genetic studies on nine aboriginal ethnic groups of Taiwan.1. Red cell enzyme systems"Anthropological Science. 107(3). 229-245 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, K. et al: "Origins of HTlv-1 IN South America"Nature Med.. 6(3). 232-233 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sonoda, S. et al: "Ancient HTLV type I provirus DNA of Andean mummy"AIDS Res. Retrovirus. 16. 1753-1756 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H. et al: "Phenotype-genotype correlation in CD36 deficiency types I and II"Thromb., Haemost. 84. 436-441 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H. et al: "Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol"J. Lipid. Res.. 38. 147-159 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Makino, m. ET AL: "Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications"J. Human Genetics. 45(2). 69-75 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, K. et al: "HTLV-1 provirus DNA in Andean mummies. Asian Pacific J. Cancer Prev."1(Suppl.). 7-9 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, K. et al: "HTLV-1 provirus DNA in Andean mummies. Asian Pacific J. Cancer Prev."1(Suppl.). 10-12 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yashiki, S. et al: "HLA-A^*26, HLA-B^*4002, HLA-B^*4006 and HLA-B^*4801 alleles predispose to asult T cell leukemia : the limited recognition of HTLV type I tax peptide anchor motifs and epitopes to generate anti-HTLV type I tax CD8+ cytotoxic T lymphocytes"AIDs Res. Hum. Retrovirus. 17. 1047-1061 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu, K. et al: "β-globin gene haplotype characteristics of Colombian Amerinds in South America"Human Heredity. 51. 54-63 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhao, S.M. et al: "High prevlence of HBV in Tibet, China"Asian Pacific J. Cancer Prev.. 2(4). 1-6 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima, A. et al: "Three major lineages of Asia Y choromosome : implication for the peopling of east and southeast Asia"Hum. Genet. 110. 80-88 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Qian, Y.P. et al: "Mitochondrial DNA polymorphisms in Yunnan nationalities in China, J."Hum. Genet. 46. 211-220 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chiba, H. et al: "CD36 deficiency and insulin resistance"Lancet. 9277. 243-244 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yanai, H. et al: "Metabolic changes in human CD36 deficiency displayed by glucose loading"Thromb. Haemost.. 86. 995-999 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsubara, M. et al: "Decreased longevity in Japanese men associated with low-molecular-weight apoliporprotein (a) phenotypes"Annal. Clin. Biochem.. 38. 120-123 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Senoo, H. et al: "Transport and storage of vitamin A in arctic animals"Cells Hepatic Sinusoid. 8. 207-209 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yashiki, S.: "HLA-A^*26, HLA-B^*4002, HLA-B^*4006 and HLA-B^*4801 alleles predispose to asult T cell leukemia : the limited recognition of HTLV type I tax peptide anchor motifs and epitopes to generate anti-HTLV type I tax CD8+ cytotoxic T lymphocytes"AIDS Res.Hum.Retrovirus. 17. 1047-1061 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu, K.: "β-globin gene haplotype characteristics of Colombian Amerinds in South America"Human Heredity. 51. 54-63 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zhao, S.M.: "High prevalence of HBV in Tibet, China"Asian Pacific J.Cancer Prev.. 2(4). 1-6 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Lema, C.: "Human papillomavirus infection among Bolivian Amazonian women"Asian Pacific J.Cancer Prev.. 2. 135-141 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Qian, Y.P.: "Mitochondrial DNA polymorphisms in Yunnan nationalities in China"J.Hum.Genet.. 46. 211-220 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tajima, A.: "Three major lineages of Asian Y choromosome : implication for the peopling of east and southeast Asia"Hum.Genet.. 110. 80-88 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsubara, M.: "Decreased longevity in Japanese men associated with low-molecular-weight apolipoprotein(a) phenotypes"Annal.Clin.Biochem.. 38. 120-123 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Chiba, H.: "CD36 deficiency and insulin resistance"Lancet. 9277. 243-244 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Senoo, H.: "Transport and storage of vitamin A in arctic animals"Cells Hepatic Sinusoid. 8. 207-209 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tajima,K.: "Origins of HTLV-I with south America"Nature Medicine. 6. 232-233 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sonoda,S.: "Ancient HTLV type I provirus DNA of Andean mummy"AIDS Res.Retrovirus. 16. 1753-1756 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Li,H.C.: "Green tea polyphenois induce apoptosis in vitro in perpehral blood T lymphocytes of adult T-cell leukemia patients"Jpn.J.Cancer Res.. 91. 34-40 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yanai,H.: "Phenotype-genotype correlation in CD36 deficiency types I and II"Thromb.Haemost.. 84. 436-441 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yanai,H.: "Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol"J.Lipid.Res.. 38. 147-159 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Makino,M.: "Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications"J.Human Genetics. 45(2). 69-75 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tajima,K.: "HTLV-1 provirus DNA in Andean mummies"Asian Pacific J.Cancer Prev.. 1(Suppl.). 7-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tajima,K.: "Geographical distribution of HTLV-I/II in South America"Asian Pacific J.Cancer Prev.. 1(Suppl.). 10-12 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nunez,L.: "Suppliment Book of Ethnoepidermiological Comparison of Andeans and Japanese"Universidad Catolica del Norte,Chile. 124 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Li, H. C.: "The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy"Nature Med.. 5. 1428-1432 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujiyoshi, T.: "Characteristic distribution of HTLV type I and HTLV type II carriers among native ethnic groups in south America"Aids Res. Human Retroviruses. 15. 1235-1239 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tajima, K.: "Origins of HTLV-1 in South America"Nature Med.. 6(3). 232-233 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Morio, S.: "Sezual behavior of commercial sex workers and their clients in Cambodia"J. Epidemiol.. 9. 175-182 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ohkura, S.: "Identification and phylogenetic characterization of human T-cell leukemia virus type I isolate from a native inhabitant (Rapa Nui) of Easter Island"J. General. Virol.. 80. 1995-2001 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamashita, M.: "Molecular epidemiology of human T-cell leukemia virus type I (HTLV-1) Brazil : the predominant HTLV-1s in South America differ from HTLV-1s of Japan and Africa, as well as those of Japanese immigrants and their relatives in Brazil"Virology. 261(1). 59-69 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishitani, A.: "Re-examination of HLA-G polymorphism in African Americans"Immunogenetics. 49(9). 808-811 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu, H.: "Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression"Proc. Natl. Acad. Sci., USA. 96(8). 4581-4585 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jin, F.: "Population genetic studies on nine aboriginal ethnic groups of Taiwan. I. Red cell enzyme systems"Anthropological Science. 107(3). 229-245 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Makino, M.: "Mitochondrial DNA mutations in Leigh syndrome and their phylogeneic implications"J. Hum. Genetics. 45(2). 69-75 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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