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Joint research on a technique of LODERS imaging.

Research Project

Project/Area Number 11694109
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionINSTITUTE FOR LIFE SUPPORT TECHNOLOGY(ILST), YAMAGATA PUBLIC CORPORATION FOR THE DEVELOPMENT OF INDUSTRY

Principal Investigator

OHTA Hiroaki  INSTITUTE FOR LIFE SUPPORT TECHNOLOGY(ILST), DEPUTY DIRECTOR GENERAL, 生物ラジカル研究所, 副所長 (00025389)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Hidekatsu  INSTITUTE FORLIFE SUPPORT TECHNOLOGY(ILST), SENIOR RESEARCHER, 生物ラジカル研究所, 主幹研究員 (10281619)
SATO Toshiyuki  INSTITUTE FOR LIFE SUPPORT TECHNOLOGY(ILST), CHIEF(YRIT), 生物ラジカル研究所, 開発研究専門員 (80281616)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordselectron spin / imaging_ / in vivo / microwave / resonator / longuitudinal relaxation time / 電子スピン共鳴
Research Abstract

Although imaging by longitudinally detected electron spin resonance (LODESR) method is a developing technique, institutes where the LODESR method has been actively researched are only our institute and University of Aberdeen. In this study, the joint research of the LODESR method was performed by these institutes. The results in our institute are development of, (1) a mutilayered element resonator for highly sensitive detection of LODESR signal, (2) a high-power low-Q RF resonator for pulse techniques, and (3) a LODESR magnetometer for wide range measurements of low fields. On the other hand, in University of Aberdeen, (4) a LODESR analyzing technique as a function of detecting frequency was developed. As a result of the joint research, (5) a pulsed LODESR measuring method at various intervals of π-pulses was developed. This is also a result of an application of (2), and makes it possible to determine longitudinal relaxation times. Measuring relaxation times is a method where the characteristics of LODESR are well utilized.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Yokoyama H., Sato T., Fukui K., Ohya-Nishiguchi H., Kamada H.: "High-power low-Q RF ESR resonator for pulse techniques"Chem. Lett.. 919-920 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato T., Yokoyama H., Ohya H., Kamada H.: "Measuring method of longitudinally detected ESR signal intensities against resonant frequencies at 250 to 950 MHz in a constant microwave field"Appl. Magn. Reson. 16. 33-43 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato T., Yokoyama H., Ohya H., Kamada H.: "A mutilayered element resonator for CW-ESR and longitudinally detected ESR at radio frequency"Appl. Magn. Reson. 17. 119-131 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yokoyama, H., Sato, T., Ohya, H., Kamada, H.: "Longitudinally Detected ESR Magnetometer for Wide Range Measurements of Low Fields"J. Magn. Reson. 150. 194-197 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Panagiotelis I, Nicholson I, Foster MA, Hutchison JM: "T^*_<1e> and T^*_<2e> maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging : application to abdominal oxygen mapping"Magn Reson Med. 46. 1223-1232 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Panagiotelis I, Nicholson I, Hutchison JM: "Electron spin relaxation time measurements using radiofrequency longitudinally detected ESR and application in oximetry"J. Magn. Reson. 149. 74-84 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yokoyama H., Sato T., Fnkui K., Ohya-Nishiguchi H., Kamada H: "High-power low-Q RF ESR resonator for pulse techniques."Chem. Lett. 919-920 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato T., Yokoyama H., Ohya H., Kamada H.: "Measuring method of longitudinally detected ESR signalintensities against resonant frequencies at 250 to 950 MHz in a constant microwave field."Appl. Magn. Reson. 16. 33-43 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato T., Yokoyama H., Ohya H., Kamada H.: "Amutilayered element resonator for CW-ESR and longitudinally detected ESR at radio frequency."Appl. Magn. Reson. 17. 119-131 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yokoyama, H., Sato, T., Ohya, H., Kamada, H.: "Longitudinally Detected ESR Magnetometer for Wide Range Measurements of Low Fields."J. Magn. Reson. 150. 194-197 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Panagiotelis I, Nicholson I, Foster MA, Hutchison JM: "T*_<ic> and T*_<2e> maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging : application to abdominal oxygen mapping."Magn Reson Med. 46. 1223-1232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Panagiotelis I, Nicholson I, Hutchison JM.: "Electron spin relaxation time measurements using radio frequency longitudinally detected ESR and application in oximetry"J. Magn. Reson. 149. 74-84 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yokoyama, H., Sato, T., Ogata, T., Ohya, H., Kamada, H: "Automatic Coupling Control of a Loop-Gap Resonator by a Variable Capacitor Attached Couplinig Coil for EPR Measurements at 650 MHz"J. Magn. Reson.. 149. 29-35 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yokoyama, H., Sato, T., Ohya, H., Kamada, H: "Longitudinally Detected ESR Magnetometer for Wide Range Measurements of Low Fields"J. Magn. Reson.. 150. 194-197 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Panagiotelis I, Nicholson I, Foster MA, Hutchison JM: "T^*_<1c> and T^*_<2c> maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging : application to abdominal oxygen mapping"Magn Reson Med. 46. 1223-1232 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Panagiotelis I, Nicholson I, Hutchison JM: "Electron spin relaxation time measurements using radiofrequency longitudinally detected ESR and application in oximetry"J. Magn. Reson.. 149. 74-84 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yokoyama H.,Tada M.,Sato T.,Ohya H,Kamada H: "Non-invasive ESR measurements for in vivo kinetics studies of a nitroxide radical in the liver of a rat by a surface-coil-type resonator under a field gradient."Chem.Lett.. 1000-1001 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yokoyama H.,Itoh O.,Aoyama M.,Obara H.,Ohya H.,Kamada H.: "In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures."Magn.Reson.Imag.. 18. 875-879 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tada M.,Yokoyama H.,Toyoda Y.,Ohya H.,Ito,T.,Ogata T.: "Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats."Appl.Magn,Reson.. 18. 575-582 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Sato,H.Yokoyama,H.Ohya,H.kamada: "Measuring method of longitudinally detected ESR signal intensities against resonant frequencies at 250 to 950 MHz in a constant microwave field"Applied Magnetic Resonance. 16. 33-43 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Sato,H.Yokoyama,H.Ohya,H.kamada: "Electrically detected magnetic resonance (EDMR) signal intensity at 300 to 900 MHz of resonant frequencies in a constant microwave field"Journal of Magnetic Resonance. 139. 422-429 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Sato,H.Yokoyama,H.Ohya,H.kamada: "A Multilayerd Element Resonator for CW-ESR and Longitudinary Detected ESR at Radio Frequency"Applied Magnetic Resonance. 17. 119-131 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Yokoyama,T.Sato,H.Ohya,H.Kamada: "High power Low-Q RF Resonator for pulse Techniques"Chemistly Letter. 919-920 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Yokoyama et al.: "EPR imaging for in vivo analysis of the half-life of a nitroxide radical in the hippocampus and cerebral cortex of rats after epileptic sezures"Free Radical Bio.Med.. 27. 442-448 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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