| Project/Area Number |
11694135
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAMOTO Yoshiharu The University of Tokyo, Graduate School of Education, Professor, 大学院・教育学研究科, 助教授 (60251427)
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| Co-Investigator(Kenkyū-buntansha) |
NOZAKI Daichi National Rehabilitation Center for the Disabled, Research Institute, Researcher, 研究員
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Fluctuation / Autonomic Regulation / Baroreflex / Heart Rate fluctuation / Stochastic Resonance / Orthostatic Dysfunction / ノイズ / 生体ゆらぎ / ホメオスタンス / 神経モデル / 動脈血圧反射 |
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| Research Abstract |
We investigated functional aspects of noise-like components of physiological signals. First, we showed that externally-added noise to the brain stern, baroreflex centers sensitized their responses in maintaining adequate blood prelusion to the brain it self. We also showed that the addition of noise was indeed useful in compensating for dysfunctions of the baroreflex centers hi certain neurological diseases. Next, we examined physiological origins of multifractal heart rate fluctuation known to be lost in a certain cardiac disease. It was shown that the rnultifractal heart rate fluctuation reflected an intrinsic, property of neuroautonomic regulatory processes. Finally, we investigated the relationship between fractal correlation of body movement time series and possible psychiatric and/or psychosomatic diseases. It was shown that the fractal correlation was lost in patients with chronic fatigue syndrome.
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