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NON-INVASIVE IMAGING OF INTERNAL BODY TEMPERATURE USING MRI FOR THERMAL THERAPIES

Research Project

Project/Area Number 11694172
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokai University

Principal Investigator

KURODA Kagayaki  ASSISTANT PROFESSOR, FACULTY OF ENGINEERING, TOKAI UNIVERSITY, 工学部, 講師 (70205243)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsMRI / Temperature / Proton chemical shift / Mapping / EPSI / LSEPSI / Phase / Laser / 超音波
Research Abstract

Our primary aim of this research project was to establish the methodology of non-invasive internal-body temperature imaging under variety of the thermal therapies. Based on the development and assessment of the elemental technologies in 2000, we have focused on the development of the internally referenced (in other word self-referenced) temperature imaging technique using naturally contained metabolite signals. The echo planar spectroscopic imaging (EPSI) technique was modified as to have line scan capability (LSEPSI) to improve the spectrum quality under existence of the magnetic field inhomogeneity. The production technique of the birdcage coil for small animals in 3T-MRI was also refined to improve the coils transmission and reception specifications. These improvement yielded clear, internally referenced temperature distribution change maps for a 20 mM citrate phantom as well as a 10 mM NAA (N-Acetyl Aspartic acid) phantom. Our trial for a rabbit brain temperature imaging using LSEP … More SI was successful to visualize the temperature distribution change using NAA of a natural abundance (-7 mM). This internally-referenced technique does not require the pixel-by-pixel subtraction unlike the phase mapping approach. This means that the technique is more durable against the inter-scan motion or the inter-scan susceptibility change.
Separate measurements for human volunteers' brains demonstrated that the water-NAA chemical shift is neither constant nor homogeneous ; It differs by locations and by individuals. The difference reaches as 0.05 ppm which corresponds to 5℃ of temperature variation. It is known that the internal brain temperature is almost homogeneous in a brain tissues, and therefore the difference is due to a factor other than temperature. Absolute brain temperature imaging still seems to be a far goal.
Overall, the 2-years research in this project has established temperature change imaging using the phase mapping method (externally referenced approach) and the LSEPSI approach (internally referenced approach) of temperature imaging. The animal coil technology for a very high field (VHF, 3T) MRI has also been completed. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] 黒田輝: "超高速磁気共鳴分光画像化法(EPSI)とその体内温度分布非侵襲画像計測への応用"インナービジョン. 14,8. 75-76 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda,K.Oshio,R.V.Mulkern,L.P.Panych,T.Nakai,T.Moriya,S.Okuda,K.Hynynen,F.A.Jolesz: "Temperature Mapping Using Water Proton Thermal Shift: Self-Referenced Method with Echo Planar Spectroscopic Imaging"Magn.Reson.Med. 43. 220-225 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 黒田輝: "MRIによる体内温度分布の非侵襲画像計測"日本機械学会誌. 102,972. 55-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 黒田輝: "超高速磁気共鳴分光画像化法(EPSI)とその体内温度分布非侵襲画像計測への応用"インナービジョン. 15,8. 87-88 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 貝沼修,奥田茂男,黒田輝,F.A.Jolesz: "MRI位相差法によるRadiofrequency ablationの温度モニタリング"J.Microwave Surg.. 15,8. 87-88 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Okuda,K.Kuroda,K.Oshio,R.V.Mulkern,V.Colucci,P.R.Morrison,O.Kainuma,F.A.Jolesz: "MR Based Temperature Monitoring for Hot Saline Injection Therapy"J.Magn.Reson.Imag.. 12. 330-338 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda,M.Jinzaki,N.McDannold,T.Nakai,T.Moriya,K.Hynynen,F.A.Jolesz: "Internally-Referenced Measurement of Prostate Temperature Using Metabolite Signals"Proc.8th Meeting ISMRM,Denver. 49 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda,O.Kainuma,S.Okuda,M.Jinzaki,P.R.Morrison,D.Kacher,S.G.Silverman,F.A.Jolesz: "Three Dimensional (3D) Temperature Imaging Using Water Proton Chemical Shift"Proc.8th Meeting ISMRM, Denver. 1340 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Non-invasive temperature imaging by MR system"Proc.ICHO 2000, Kyong-ju. 119 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Non-Invasive MR Thermography"Proc.IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering. 692-693 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda,R.V.Mulkern,K.Oshio,N.McDannold,K.Hynynen,T.Nakai,T.Okada,A.Matsumura,K.Yanaka,F.A.Jolesz: "Feasibility of Internally-Referenced Temperature Imaging Using Metabolite Signals"Proc.9th Meeting ISMRM, Grasgow. 2189 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.J.McDannold,R.V.Mulkern,K.Kuroda,K.H.Hynynen: "Is Absolute Temperature Measurement in the Breast with H1 Spectroscopic Imaging Feasible?"Proc.9th Meeting ISMRM, Grasgow. 2190 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Venkatesh,D.F.Kacher,K.Kuroda,D.Balamore,F.A.Jolesz,M.S.Albert: "Temperature Measurement Using the 129 Xe Chemical Shift"Proc.9th Meeting ISMRM, Grasgow. 2194 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Okuda,K.Kuroda,K.Oshio,H.Fujiwara,T.Kurata,M.Jinzaki,H.Shinmoto,A.Tanimoto,Y.Imai,Y.Yuasa,S.Kuribayashi: "MR-Based Temperature Monitoring for Radiofrequency Ablation with Expandable Needle Electrode"Proc.9th Meeting ISMRM, Grasgow. 2202 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 黒田輝: "第6章新しい診断・計測技術,第3節MRIによる脳内温度分布の非侵襲画像計測,226-233,高倉公朋監,脳神経外科の最先端No.2,21世紀の新領域とニューテクノロジー"先端医療技術研究所,東京. 8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Echo planar spectroscopic imaging and its application to non-invasive temperature imaging"Inner Vision. 14, 8. 75-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda, K.Oshio, R.V.Mulkern, L.P.Panych, T.Nakai, T.Moriya, S.Okuda, K.Hynynen, F.A.Jolesz: "Temperature mapping using water proton chemical shift : self-referenced method with echo planar spectroscopic imaging"Magn.Reson.Med.. 43. 220-225 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Non-invasive imaging of internal body temperature using MRI"Japanese Journal of Mechanical Engineering. 102, 972. 55-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Echo planar spectroscopic imaging and its application to non-invasive temperature imaging : 2nd Report"Inner Vision. 15, 8. 87-88 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Okuda, K.Kuroda, K.Oshio, R.V.Mulkern, V.Colucci, P.R.Morrison, O.Kainuma, F.A Jolesz: "MR Based Temperature Monitoring for Hot Saline Injection Therapy"J.Magn.Reson.Imag.. 12. 330-338 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] O.Kainuma, S.Okuda, K.Kuroda, Ferenc A.Jolesz: "Temperature monitoring of radio frequency ablation with MR phase mapping"J.Microwave Surg.. 18. 127-131 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Chapter 6, New techniques for diagnosis and instrumentation, Section 3, Non-invasive imaging of brain temperature using MRI"Eds.K.Takakura, Frontier of neuro-surgery No. 2, New fields and technologies, Setan-Iryo-Kenkyusho, Tokyo, Japan. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda, M.Jinzaki, N.McDannold, T.Nakai, T.Moriya, K.Hynynen, F.A.Jolesz: "Internally-Referenced Measurement of Prostate Temperature Using Metabolite Signals"Proc.8th Meeting ISMRM, Denver. 49 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda, O.Kainuma S.Okuda, M.Jinzaki, P.R.Morrison, D.Kacher, S.G.Silverman, F.A.Jolesz: "Three Dimensional (3D) Temperature Imaging Using Water Proton Chemical Shift"Proc.8th Meeting ISMRM, Denver. 1340 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Okuda, K.Kuroda, K.Oshio, R.V.Mulkern, V.Colucci, P.R.Morrison, O.Kainuma, F.A.Jolesz: "MRI temperature measurement for hot saline injection therapy-In vivo study"Proc.8th Meeting ISMRM, Denver. 1336 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Non-invasive temperature imaging by MR system"Proc.ICHO 2000, Kyong-ju. 119 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda: "Non-Invasive MR Thermography"Proc.IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering. 692-693 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda, R.V.Mulkern, K.Oshio, N.McDannold, K.Hynynen, T.Nakai, T.Okada, A.Matsumura, K.Yanaka, F.A.Jolesz: "Feasibility of Internally-Referenced Temperature Imaging using Metabolite Signals"Proc.9th Meeting ISMRM, Grasgow. 2189 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.J.McDannold, R.V.Mulkern, K.Kuroda, K.H.Hynynen: "Is Absolute Temperature Measurement in the Breast with H1 Spectroscopic Imaging Feasible?"Proc.9th Meeting ISMRM, Grasgow. 2190 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Venkatesh, D.F.Kacher, K.Kuroda, D.Balamore, F.A.Jolesz, M.S.Albert: "Temperature Measurement Using the 129 Xe Chemical Shift"Proc.9th Meeting ISMRM, Grasgow. 2194 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Okuda, K.Kuroda, K.Oshio, H.Fujiwara, T.Kurata, M.Jinzaki, H.Shinmoto, A.Tanimoto, Y.Imai, Y.Yuasa, S.Kuribayashi: "MR-based Temperature Monitoring for Radiofrequency Ablation with Expandable Needle Electrode"Proc.9th Meeting ISMRM, Grasgow. 2202 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kuroda,K.Oshio,R.V.Mulkern,L.P.Panych,T.Nakai,T.Moriya,S.Okuda,K.Hynynen,F.A.Jolesz: "Temperature Mapping Using Water Proton Thermal Shift : Self-Referenced Method with Echo Planar Spectroscopic Imaging"Magn.Reson.Med. 43. 220-225 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 黒田輝: "MRIによる体内温度分布の非侵襲画像計測"日本機械学会誌. 102・972. 55-56 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 黒田輝: "超高速磁気共鳴分光画像化法(EPSI)とその体内温度分布非侵襲画像計測への応用"インナービジョン. 15・8. 87-88 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kuroda,M.Jinzaki,N.McDannold,T.Nakai,T.Moriya,K.Hynynen,F.A.Jolesz: "Internally-Referenced Measurement of Prostate Temperature Using Metabolite Signals"Proc.8th Meeting ISMRM, Denver. 49 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kuroda,O.Kainuma,S.Okuda,M.Jinzaki,P.R.Morrison,D.Kacher,S.G.Silverman,F.A.Jolesz: "Three Dimensional (3D) Temperature Imaging Using Water Proton Chemical Shift"Proc.8th Meeting ISMRM, Denver. 1340 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kuroda: "Non-invasive temperature imaging by MR system"Proc.ICHO 2000,Kyong-ju. 119 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 黒田輝: "第6章新しい診断・計測技術,第3節MRIによる脳内温度分布の非侵襲画像計測、226-233,高倉公朋監,脳神経外科の最先端No.2,21世紀の新領域とニューテクノロジー"先端医療技術研究所,東京. 8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kuroda,K.Hynynen,F.A.Jolesz et al.: "Temperature Mapping Using Water Proton Thermal Shift: Self-Referenced Method with Echo Planar Spectroscopic Imaging"Magn.Reson.Med.. 43. 220-225 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒田輝: "MRIによる体内温度分布の非侵襲画像計測"日本機械学会誌. 102. 55-56 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒田輝: "超高速磁気共鳴分光画像化法(EPSI)とその体内温度分布非侵襲画像計測への応用"インナービジョン. 14. 75-76 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Okada,K.Kuroda,K.Oshio et al.: "Temperature Measurement for Hot Saline Injection Therapy"Proc.7th Meeting ISMRM,Philadelphia. 3. 1932 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Kuroda,J.Kettenbach,P.Morrison et al.: "Clinical trials of MR temperature imaging for laser ablation of brain tumor"Proc.7th Meeting ISMRM,Philadelphia. 1. 675 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒田輝: "明日の脳神経外科 第6章 新しい診断・計測技術,3.MRIによる脳内温度分布の非侵襲画像計測"先端医療技術研究所 (印刷中). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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