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Analysis of TCR/HLA/ peptide interaction and investigation of etiology of autoimmune diseases

Research Project

Project/Area Number 11694294
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

NISHIMURA Yasuharu  KUMAMOTO UNIV., GRAD. SCHL. MED. SCIENCES, PROFESSOR, 大学院・医学研究科, 教授 (10156119)

Co-Investigator(Kenkyū-buntansha) JUN-ICHI Kira  KYUSHU UNIV., GRAD. SCHL. MED. DEPT. OF NEUROLOGY NEUROLOGICAL INST., PROFESSOR, 大学院・医学研究科, 教授 (40183305)
IRIE Atushi  KUMAMOTO UNIV., GRAD. SCHL. MED. SCIENCES, RES. ASSOCIATE, 大学院・医学研究科, 助手 (30250343)
SENJU Satoru  KUMAMOTO UNIV., GRAD. SCHL. MED. SCIENCES, ASSOC. PROFESSOR, 大学院・医学研究科, 講師 (50274709)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥9,770,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2001: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2000: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsAutoimmune diseases / Molecular mimicry / Type I diabetes / Vogt-Koyanagi-Harada disease / Autoreactive CD4^+ T cells / Expression cloning of T cell epitopes / HLA class II / T cell response / 感染性微生物 / グルタミン酸脱炭酸酵素65 / MHCクラスII分子 / 発現クローニング / Vogt-小柳-原田病 / 虹彩毛様体炎 / HLA / SEREX / LEDGF / UACA / 多発性硬化症 / ミエリン蛋白 / HLAクラスII分子 / 自己抗原ペプチド / エピトープライブラリー
Research Abstract

In the previous studies, we discovered assedations between specific HLA class II alleles and susceptibility to autoimmune diseases, and examined binding peptide motifs of disease-associated HLA class II molecules. In this study, to clarify the mechanisms of the disease-association of specific HLA alleles, we carried out the following researches. Identification of self peptides recognized by disease-related autoreactive T cell clones. We established many auto-antigen specific CD4^+ T cell clones from Asian type multiple sclerosis (MS) and anti-phosopholipid antibody syndrome (APS) patients. We identified many epitopes derived from self antigens and restricting HLA class II molecules, and examined the cytokines produced by the T cell clones. In addition, we searched for the target autoantigen of Vogt -Koyanagi-Harada disease (VKH), an autoimmune diseas e in which inflammatory disorders occur in multiple organs containing melanocytes. By SEREX method, we identified LEDGF (Lens Epithelial … More Cel l Derived Growth Factor) and UACA (Uveal Autoantigen with Coiled coil domains and Ankyrin repeats) as candidates for the target antigen. 2) Establishment of a method to identify cross-reactive epitopes recognized by disease-related autoreactive T cells.We established an expression cloning system to identify epitopes for CD4^+ T cell clones. Using this system, we examined the pattern of epitopes cross-recognized by two CD4^+ T cell clones established from Type I diabetes patients and specific to glutamate decarboxylase 65 (GAD65). Based on this information, we identified several mimicry epitopes of microbial antigen origin. 3) Analysis of T cell response induced by analogues of agonistic epilopes.We generated series of L cell transfectants expressing complexes of HLA-DR4 (DRB1^*0406) and agonist or partial agonist peptides in various densities. Using the transfectants, we discovered that a certain partial agonist peptide, when presented in a very high density, can induce T cell response in a similar magnitude as a full agonist peptide, andthat the T cell response is not accompanied by phosphorylation of ZAP-70 and LAT. We identified unique profiles of produced cytokines, down-modulation of TCR, and intracellular signaling events associated with this unique T cell response. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (125 results)

All Other

All Publications (125 results)

  • [Publications] Nakatsura, T.: "Cellular and Humoral Immune Responses to A Human Pancreatic Cancer Antigen, CLP, Originally Defined by the SEREX Method"Eur. J. Immunol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Cross-linking HLA-DR molecules on Thl cells induces anaergy in association with increased level of cyclin-dependent kinase inhibitor p27Kip1"Immunol. Lts.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kamata, T.: "Amino acid residues in the αIIb subunit that are critical for ligand binding to integrin αIIbβ3 are clustered in the β-propeller model"J. Biol. Chem.. 276. 44275-44283 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masuda, M.: "Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein"Biochem. Biophys. Res. Comm.. 290. 1022-1029 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Minohara, M.: "Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls"Tissue Antigens. 57. 447-456 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maeda, A.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, cancer-associated retinopathy antigen, to achieve a clinical better prognosis in a paraneoplastic syndrome"Eur. J. Immunol.. 31. 563-572 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue, R.: "Identification of β-lactoglobulin-derived peptides and class II HLA molecules recognized by T Cells from patients with milk allergy"Clin. Exp. Allergy. 31. 1126-1134 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada, K.: "Identification of a novel autoantigen UACA in patients with panuveitis"Biochem. Biophys. Res. Comm.. 280. 1169-1176 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakatsura, T.: "Gene cloning of immunogenic antigens over-expressed in pancreatic cancer"Biochem. Biophys. Res. Comm.. 281. 936-944 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujii, S., Uemura, Y.: "Establishment of an expression cloning system for CD4^+ T cell epitopes"Biochem. Biophys. Res. Comm.. 284. 1140-1147 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishimura, Y.: "(review) Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population"Modern Rheumatology. 11. 103-112 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada, K.: "Humoral immune response directed against LEDGF in patients with VKH"Immunol. Letters. 78. 161-168 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村 泰治: "MHCによるTリンパ球への抗原提示"学術月報,特集:免疫学研究の最新動向. 54・7. 685-689 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 植村 靖史: "CLIP置換型インパリアント鎖遺伝子ライブラリーを用いた自己反応性CD4^+T細胞が認識する抗原ペプチドの多様性の解析"臨床免疫. 37・2. 157-165 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Senju, S.: "Immunocytochemical Analyses and Targeted Gene Disruption of GTPBP1"Mol. Cell Biol.. 20. 6195-6200 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lai, Z-F., Chen, Y-Z: "An amiloride sensitive and voltage-dependent Na^+ channel in an HLA-DR-restricted human T cell clone"J. Immunol.. 165. 83-90 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Mouse and Human GTPBP2, Newly identified Members of the GP-1 family of GTPase"Biochem. Biophys. Res. Commun.. 272. 456-465 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukuzawa, T.: "Both the HLA-DPB 1 and -DRB 1 allels correlate with risk for multiple sclerosis in Japanese clinical phenotypes and gender as important factors"Tissue Antigens. 55. 199-205 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ito, H.: "Analysis of T-cell Responses to the β2-Glycoprotein I-Derived Peptide Library in Patients with Anti-β2-Glycoprotein I Antibody-Associated Autoimmunity"Human Immunol.. 61. 366-377 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasukawa, M.: "Analysis of HLA-DRB 1 alleles in Japanese patients with chronic myelogenous leukemia"Am. J. Hematol.. 63. 99-101 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tabata, H.: "Ligation of HLA-DR molecules on B cells induces enhanced expression of IgM heavy chain genes in association with Syk activation"J. Biol. Chem.. 275. 34998-35005 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shigematsu, H.: "Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis : implications for molecular mimicry and cross-recognition among mitochondrial autoantigens"Hepatology. 32. 901-909 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, S.: "Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus"Mod. Rheumatol.. 10. 235-239 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higgins, JM.: "The role of α and β chains in ligand recognition by β7 integrins"J Biol Chem.. 275. 25652-25664 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 尹 忠秀: "アナログ抗原ペプチドを用いた抗腫瘍免疫の増強"臨床免疫. 190-197 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "抗原のプロセッシングとT細胞への提示機構"臨床検査. 44・4. 354-365 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "T細胞に抗原を認識させる主要組織適合抗原の構造と機能"蛋白質・核酸・酵素. 45・7. 1205-1218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "T細胞抗原受容体におけるリガンドと伝達シグナルの多様性:抗原の質的変化が応答に及ぼす影響"細胞工学. 19・2. 228-238 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka, Y.: "Identification of peptide superagonists for a self-K-ras-reactive CD4^+ T cell clone, using combinatorial peptide libraries and mass spectrometry"J. Immunol.. 162. 7155-7161 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamasaki, K.: "HLA-DPB1^*0501-associated optico-spinal multiple sclerosis : clinical, neuroimaging and immunogenetic studies"Brain. 122. 1689-1696 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yun, C.: "Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4^+ T-cell clone reacting to TEL/AML1 fusion protein"Tissue Antigens. 54. 153-161 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang XP: "Puzon-McLaughlin W, Irie A, Kovach N, Prokopishyn NL, Laferte S, Takeuchi K, Tsuji T, Takada Y. α3β1 adhesion to laminin-5 and invasin : critical and differential role of integrin residues clustered at the boundary between α3 N-terminal repeats 2 and 3"Biochemistry. 38. 14424-14431 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "T細胞の抗原認識と応答の多様性-APLを用いた研究により明らかとなったT細胞応答の本質"実験医学増刊号「免疫研究の新たな展開」. 17・12. 124-136 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村 泰治: "新版・臨床免疫学"講談社. 8(55-62) (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村 泰治: "最新 膠原病・リウマチ学"朝倉書店. 7(25-34) (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 入江 厚: "Annual Review免疫2001"中外医学社. 7(84-93) (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "わかる実験医学シリーズ:免疫がわかる"羊土社. 12(44-55) (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "Bio Science用語ライブラリー免疫"羊土社. 5(73-77) (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "現代医学の基礎"岩波書店. 23(221-243) (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "医科遺伝学"南江堂. 16(251-266) (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "医科遺伝学"南江堂. 32(110-141) (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西村泰治: "分子予防医学"医学書院. 12(324-335) (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 尹 忠秀: "Annual Review免疫2000"中外医学社. 9(280-288) (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Cross-linking HLA-DR molecules on Th1 cells induces anaergy in association with increased level of cyclin-dependent kinase inhibitor p27Kip1"Immunol. Letters. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakatsura, T.: "Cellular and Humoral Immune Responses to A Human Pancreatic Cancer Antigen, CLP, Originally Defined by the SEREX Method"Eur. J. Immunol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada, K.: "Identification of a novel autoantigen UACA in patients with panuveitis"Biochem. Biophys. Res. Comm.. 280. 1169-1176 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakatsura. T.: "Gene cloning of immunogenic antigens over-expressed in pancreatic cancer"Biochem. Biophys. Res. Comm.. 281. 936-944 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maeda, A.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, cancer-associated retinopathy antigen, to achieve a clinical better prognosis in a paraneoplastic syndrom"Eur. J. Immunol.. 31. 563-572 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Minohara, M.: "Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls"Tissue Antigens. 57. 447-456 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Nishimura: "Molecular and cellular analyses of HLA class II - associated susceptibility to autoimmune diseases in the Japanese population"Modern Rheumatology. 11. 103-112 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue, R.: "Identification of β-lactoglobulin-derived peptides and class II HLA molecules recognized by T Cells from patients with milk allerg"Clin. Exp. Allergy. 31. 1126-1134 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujii, S., Uemura, Y.: "Establishment of an expression cloning system for CD4^+ T cell epitopes"Biochem. Biophvs. Res. Comm.. 284. 1140-1147 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada, K.: "Humoral immune response directed against LEDGF in patients with VKH"Immunol. Letters. 78. 161-168 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kamata, T.: "Amino acid residues in the αIIb subunit that are critical for ligand binding to integrin αIIbβ3 are clustered in the β-propeller model"J. Biol. Chem.. 276. 44275-44283 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masuda, M.: "Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclea protein"Biochem. Biophys. Res. Comm.. 290. 1022-1029 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Senju, S.: "Immunocytochemical Analyses and Targeted Gene Disruption of GTPBP1"Mol. Cell Biol.. 20. 6195-6200 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lai, Z-F., Chen, Y-Z.: "An amiloride sensitive and voltage-dependent Na^+ channel in an HLA-DR-restricted human T cell clone"J. Immunol.. 165. 83-90 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Mouse and Human GTPBP2, Newly identified Members of the GP-1 family of GTPase"Biochem. Biophys. Res. Commun.. 272. 456-465 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukuzawa, T.: "Both the HLA-DPB1 and -DRB1 allels correlate with risk for multiple sclerosisin Japanese clinical phenotypes and gender as important factors"Tissue Antigens. 55. 199-205 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ito, H.: "Analysis of T-cell Responses to the β2-Glycoprotein I-Derived Peptide Library in Patients with Anti-β2-Glycoprotein I Antibody-Associated Autoimmunity"Human Immunol.. 61. 366-377 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasukawa, M.: "Analysis of HLA-DRB1 alleles in Japanease patients with chronic myelogenous leukemi"Am. J. Hematol.. 63. 99-101 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tabata, H.: "Ligation of HLA-DR molecules on B cells induces enhanced expression of IgM heavy chain genes in association with Syk activation"J. Biol. Chem.. 275. 34998-35005 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shigematsu, H.: "Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens"Hepatology. 32. 901-909 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, S.: "Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus"Mod. Rheumatol.. 10. 235-239 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higgins, JM.: "The role of α and β chains in ligand recognition by β 7 integrins"J. Biol. Chem.. 275. 25652-25664 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka, Y.: "Identification of peptide superagonists for a self-K-ras-reactive CD4^+ T cell clone, using combinatorial peptide libraries and mass spectrometry"J. Immunol.. 162. 7155-7161 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] .Yamasaki, K.: "HLA-DPB1^*0501-associated optico-spinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies"Brain. 122. 1689-1696 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsushita, S.: "Peptide length-dependent TCRantagonism on class II HLA-restricted responses of PBMC and T-cell clones"Eur. J. Immunol.. 29. 431-436 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yun, C.: "Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4^+ T-cell clone reacting to TEL/AML1 fusion protein"Tissue Antigens. 54. 153-161 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakatsura, T.: "Cellular and Humoral Immune Responses to A Human Pancreatic Cancer Antigen, CLP, Originally Defined by the SEREX Method"Eur J Immunol.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kudo, H.: "Cross-linking HLA-DR molecules on Th1 cells induces anaergy in association with increased level of cyclin-dependent kinase inhibitor p27Kip1"Immunol.Lts.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamata, T.: "Amino acid residuces in the αIIb subunit that are critical for ligand binding to integrin αIIbβ3 are clustered in the β-propeller model"J.Biol.Chem.. 276. 44275-44283 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masuda, M.: "Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein"Biochem.Biophys.Res.Comm.. 290. 1022-1029 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Minohara, M.: "Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls"Tissue Antigens. 57. 447-456 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Maeda, A.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, cancer-associated retinopathy antigen, to achieve a clinical better prognosis in paraneoplastic syndrome"Eur.J.Immunol.. 31. 563-572 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inoue, R.: "Identification of β-lactoglobulin-derived peptides and class II HLA molecules recognize by T Cells from patients with milk allergy"Clin.Exp.Immunol.. 31. 1126-1134 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada, K.: "Identification of a novel autoantigen UACA in patients with panuveitis"Biochem.Biophys.Res.Comm.. 280. 1169-1176 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakatsura, T.: "Gene cloning of immunogenic antigens over-expressed in pancreatic cancer"Biochem.Biophys.Res.Comm.. 281. 936-944 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujii, S., Uemura, Y.: "Establishiment of an expression cloning system for CD4^+T cell epitopes"Bilchem.Biophys.Res.Comm.. 284. 1140-1147 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishimura, Y.: "(review) Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population"Modern Rheumatology. 11. 103-112 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada, K.: "Humoral immune response directed against LEDGF in patients with VKH"Immunol.Letters. 78. 161-168 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 西村 泰治: "MHCによるTリンパ球への抗原提示"学術月報,特集:免疫学研究の最新動向. 54・7. 685-689 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 植村 靖史: "CLIP置換型インバリアント鎖遺伝子ライブラリーを用いた自己反応型CD4^+T細胞が認識する抗原ペプチドの多様性の解析"臨床免疫. 37・2. 157-165 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 西村 泰治: "新版・臨床免疫学「HLAの構造と機能」"講談社. 8(55-62) (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Senju,S.: "Immunocytochemical Analyses and Targeted Gene Disruption of GTPBP1."Mol.Cell Biol.. 20. 6195-6200 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tabata,H.: "Ligation of HLA-DR molecules on B cells induces enhanced expression of IgM heavy chain genes in association with Syk activation."J.Biol.Chem.. 275. 34998-35005 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Lai,Z-F.: "An amiloride sensitive and voltage-dependent Na^+ channel in an HLA-DR-restricted human T cel clone."j.Immunol.. 165. 83-90 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maeda,A.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin,cancer-associated retinopathy antigen, to achieve a clinical better prognosis in a paraneoplastic syndrome."Eur J Immunol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Shigematsu,H.: "Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis : implications for molecular mimicry and cross-recognition among mitochondrial autoantigens."Hepatology. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukazawa,T.: "Both the HLA-DPB1 and-DRB1 alleles correlate with risk for multiple sclerosis in Japanese : Clinical phenotypes and gender as important factors."Tissue Antigens. 55. 199-205 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Minohara,M.: "Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls."Tissue Antigens. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kudo,H.: "Mouse and Human GTPBP2, Newly identified Members of the GP-1 family of GTPase."Biochem.Biophys.Res.Commun.. 272. 456-465 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakatsura,T.: "Gene cloning of immunogenic antigens over-expressed in pancreatic cancer."Biochem.Biophys.Res.Comm.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamada,K.: "Identification of a novel autoantigen UACA in patients with panuveitis."Biochem.Biophys.Res.Comm.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ito,H.: "Analysis of T-cell responses to the β2-glycoprotein I-derived peptide libraly in patients with anti-β2-glycoprotein I antibody-associated autoimmunity."Human Immunol.. 61. 366-377 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasukawa,M.: "Analysis of HLA-DRB1 alleles in Japanease patients with chronic myelogenous leukemia."Am.J.Hematol.. 63. 99-101 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishimura,Y.: "(review) Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population."Modern Rheumatology. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Morimoto,S.: "Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus."Mod.Rheumatol.. 10. 235-239 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "抗原のプロセッシングとT細胞への提示機構"臨床検査. 44・4. 354-365 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 伊藤裕志: "HLAクラスII分子による抗原提示と疾患感受性"Molecular Medicine特集「ゲノム多様性と機能解析-MHC多型と疾患感受性」. 37・5. 558-570 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "T細胞に抗原を認識させる主要組織適合抗原の構造と機能"蛋白質・核酸・酵素. 45・7. 1205-1218 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "T細胞抗原受容体におけるリガンドと伝達シグナルの多様性:抗原の質的変化が応答に及ぼす影響"細胞工学,特集「免疫システムを支える抗原情報伝達の多様な分子機構」. 19・2. 228-238 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "HLAと疾患感受性"日本医師会雑誌,特集「臨床医のための免疫学」. 123・11. 1754 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 藤井慎嗣: "CLIP置換型インバリアント鎖遺伝子を利用したHLAクラスII・ペプチド複合体発現細胞ライブラリーの構築:がん免疫療法への応用の可能性"分子細胞治療,特集「がん免疫療法の最前線」. 1・1. 14-22 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "11巻現代医学の基礎「感染と生体防御」「免疫制御機構破綻の修復-将来の方向性-ワクチン開発の新戦略」"岩波書店(東京). 11(221-243) (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "Bio Science用語ライブラリー免疫,「概論:ペプチド抗原の提示とMHC」"羊土社(東京). 3(73-77) (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "わかる実験医学シリーズ:免疫がわかる,「MHCによるT細胞への抗原提示しくみ」"羊土社(東京). 44-55 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "南山堂医学大辞典,「組織適合性抗原」「HLA」ほか"南山堂(東京)(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 西村泰治: "膠原病・リウマチ疾患総論,「免疫遺伝学」"朝倉書店(東京)(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yun,C.: "Augmentation of immune response by altered peptide ligands of the antigenic peptide in human CD4^+T cell clone reacting to TEL/AML1 fusion protein."Tissue Antigens. 54. 153-161 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamasaki,K.: "HLA-DPB1^*0501-associated optico-spinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies."Brain. 122. 1689-1696 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanaka,Y.: "Identification of peptide superagonists for a self-K-ras-reactive CD4^+T cell clone, using combinatorial peptide libraries and mass spectrometry."J. Immunol.. 162. 7155-7161 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ito,H.: "Analysis of T-cell responses to the β2-glycoprotein I-derived peptide libraly in patients with anti-β2-glycoprotein I antibody-associated autoimmunity."Human Immunol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukazawa,T.: "Both the HLA-DPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese: Clinical phenotypes and gender as important factors."Tissue Antigens. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 尹 忠秀: "アナログ抗原ペプチドを用いた抗腫瘍免疫の増強"臨床免疫. 32(2). 190-197 (1999)

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      1999 Annual Research Report
  • [Publications] 西村 泰治: "HLA分子と結合ペプチドの構造"Diabetes Frontier. 10(2). 267-275 (1999)

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      1999 Annual Research Report
  • [Publications] 三野原 元澄: "多発性硬化症"臨床検査. 43(13). 1647-1655 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "T細胞抗原受容体におけるリガンドと伝達シグナルの多様性:抗原の質的変化が応答に及ぼす影響"細胞工学・特集「免疫システムを支える抗原情報伝達の多様な分子構造」. 19(2). 228-238 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "CLIP置換インバリアント鎖遺伝子を利用したHLAクラスII・ペプチド複合体発現細胞ライブラリー;腫瘍抗原同定への応用"分子細胞治療 特集「がん免疫療法の最前線」. 1(1). 14-21 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "T細胞に抗原を認識させる主要組織適合抗原の構造と機能"蛋白質・核酸・酵素. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "医科遺伝学「免疫遺伝学」"南江堂(東京). 32(110-141) (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "医科遺伝学「免疫病の遺伝学」"南江堂(東京). 16(251-266) (1999)

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      1999 Annual Research Report
  • [Publications] 西村 泰治: "分子予防医学「MHCとペプチド」"医学書院(東京). 12(324-335) (1999)

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      1999 Annual Research Report
  • [Publications] 尹 忠秀: "Annual Review免疫2000「抗原ペプチドのアナログによる抗腫瘍免疫の増強」"科学評論社(東京). 9(280-288) (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西村 泰治: "11巻現代医学の基礎「感染と生体防御」14「ワクチン開発の新戦略」"岩波書店(東京). 23(221-243) (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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