| Project/Area Number |
11694304
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHIMOTO Takashi Nagoya City University, Medical School, Associate Professor, 医学部, 助教授 (10094393)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Satoshi Nagoya City University, Medical School, Assistant Professor, 医学部, 講師 (50234935)
MANABE Tadao Nagoya City University, Medical School, Professor, 医学部, 教授 (80127141)
SUZUKI Tatsuya Nagoya City University, Medical School, Research Associate, 医学部, 助手 (00285222)
KUNIMATSU Mitoshi Nagoya City University, Medical School, Assistant Professor, 医学部, 講師 (70145746)
FATAKUCHI Mitsuru Nagoya City University, Medical School, Research Associate, 医学部, 助手 (60275120)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | liver transplantation / immunosuppressive protein / cancer metastasis / Indole amine 2,3-deoxygenase (IDO) / 免疾抑制蛋白 / 免疫抑制蛋白 |
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| Research Abstract |
1. We have succeeded in complete withdrawing of the immuno-suppressive drugs from 2 more cases with living related liver transplantation in our institution. Now, we have totally 3 cases with immuno-tolerance after liver transplantation.
2. Indole amine 2,3-deoxygenase (EDO) which was reported by D.H Munn in 1999, . or novel immuno-suppressive proteins were searched using SELDI- Protein Chips.
3. Inhibitor of EDO was administered to the mice with liver transplantation that had naturally developed immuno-tolerance. However, we could not obtained anovel results
4. We confirmed DNA sequence of rat IDO and induction of IDO in the allogenic orthotopic liver transplantation livers.
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