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Establishment of two dimensional bone density distribution imaging technology by an ultrasonic method and development of diagnosis system of osteoporosis

Research Project

Project/Area Number 11792012
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionDOSHISHA UNIVERSITY

Principal Investigator

OTANI Takahiko  Doshisha University, Faculty of Engineering, Professor, 工学部, 教授 (50066205)

Co-Investigator(Kenkyū-buntansha) TAKAI Shinro  Kyoto Prefectural University of Medicine, Department of Orthopaedic Surgery, Lecturer, 医学部, 講師 (10226730)
MATSUKAWA Mami  DoshishaUniversity, Faculty of Engineering, Associate Professor, 工学部, 助教授 (60288602)
SAKAGUCHI Kazuhiko  Doshisha University, Faculty of Engineering, Professor, 工学部, 教授 (40066212)
SUZAKI Takuji  HORIBA Ltd, Research and Development Center, Senior Manager, 開発センター, シニアマネージャー(研究職)
TAKADA Masahiko  Shiga University of Medical Sciences, Department of Radiology, Assistant, 放射線科, 助手 (10187974)
佐藤 昌利  京都市工業試験場, 産業工芸部, 主席研究員
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 2001: ¥7,200,000 (Direct Cost: ¥7,200,000)
Keywordsosteoporosis / cancellous bone / Biot's theory / ultrasonic wave speed / fast wave / slow wave / ultrasonic wave attenuation / acoustical imaging / cancellous bone / porous structure / trabecullar structure / trabecular structure
Research Abstract

1. Realization of high resolution two dimensional imaging of bone density.
High resolution focusing ultrasonic transmitter and receiver have been developed by use of piezopolymer and the lateral resolution (the ultrasonic beam width) of 1.6 mm has been achieved. Two dimensional imaging of bone density of bovine cancellous bone specimens (in vitro) and the distal end of radius of human subjects (in vivo) has been realized by the novel ultrasonic method using the high resolution ultrasonic transducers with mechanical two dimensional scanning.
2. Quantitative evaluation of the density and the elastic modulus of the trabecular structure of cancellous bone.
(1) The causality between the ultrasonic propagation parameters (propagation speeds and transmitted signal amplitudes of both the fast and slow waves) and the cancellous bone density has been revealed. The novel ultrasonic image is compared with the micro focus X-ray computed tomography image.
(2) The ultrasonic wave propagation path for in … More vivo measurement of cancellous bone is modelized and the density and the elastic modulus of cancellous bone is formulated and expressed by the ultrasonic wave parameters and the electro-acoustic conversion parameters. A new quantitative measurement method of bone density and bone elasticity is proposed.
(3) Computer programs for two dimensional bone density imaging based on the ultrasonic transmitted waves are developed.
3. Analysis of mechanical properties and trabecular structure of cancellous bone.
Three dimensional trabecular structure of cancellous bone has been analyzed and mechanical properties (load characteristics and fracture behavior) have been studied. The mechanical properties of cancellous bone are compared with the bone density value measured by the ultrasonic method.
4. Development and evaluation of tissue-mimicking materials (phantom) and artificial bone.
Ultrasonic wave characteristics of cancellous bone mimicking material (porous honeycomb ceramics) and soft-tissue mimicking material (particle compounded gels) have been studied as standard media (phantom) to calibrate the ultrasonic diagnostic equipment. Artificial bone made by wallastinite ceramics, artificial articular cartilage using PVA-Hydrogel have been studied.
5. Future perspective of the researches.
The next stage of the researches is to establish a bone strength index based on the ultrasonic or elastic properties and on the statistical analysis of huge clinical data. The next stage has already been selected and started as a development project of the Japan Science and Technology Corporation to create a new industry. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (60 results)

All Other

All Publications (60 results)

  • [Publications] 岩崎祐喜他: "骨粗鬆症海綿骨の骨梁構造変化に関する研究(第2報)"日本臨床バイオメカニクス学会誌. Vol.20. 225-229 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Physical Principles and Theoretical Concepts of Transient Acoustic Field"Japanese Journal of Applied Physics. Vol.39 Pt.1, No.5B. 2888-2897 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 佐藤昌利他: "水分を多く含む顆粒を用いたプレス成形体の圧力伝達機構の解析"材料(J. Soc. Mat. Sci., Japan). Vol.49 No.6. 611-616 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 福田幸久他: "膝関節の衝撃伝達機構に関する力学的研究(第2報)"日本臨床バイオメカニクス学会誌. Vol.21. 205-210 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 江坂拓南他: "骨粗鬆症海綿骨の力学的特性に関する研究(第2報)"日本臨床バイオメカニクス学会誌. Vol.21. 449-454 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.FUKUDA et al.: "Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage"Clinical Biomechanics. Vol.15. 516-521 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大谷隆彦: "集束音場のパルス応答"電子情報通信学会技術研究報告. US2000-96. 27-34 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大谷隆彦: "集束音場のパルス応答"海洋音響学会誌. Vol.28 No.3. 139-146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.SATO et al.: "Compaction behavior of granules for semi-dry press forming obtained with a stirring granulator"Materials Science for the 21st Century (The Society of Materials Science, Japan). Vol.B. 107-110 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 光成淳史他: "大腿骨頚部骨折の生力学的研究(第3報)-海綿骨のせん断破壊特性-"日本臨床バイオメカニクス学会誌. Vol.21. 265-268 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.WATANABE et al.: "Prediction of mechanical properties of healing fracture using acoustic emission"Journal of Orthopaedic Research. Vol.19 No.4. 548-553 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 渡部欣忍他: "延長仮骨の成熟期間に影響を与えた因子-AE法による骨癒合評価をもとに-"日本創外固定・骨延長学会誌. No.12. 87-93 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大谷隆彦: "海綿骨の超音波伝搬特性"Osteoporosis Japan. Vol.9 no.4. 630-636 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.MATSUKAWA et al.: "Application of a Suspension Theory to Particle-Dispersed Agarose Gels"Japanese Journal of Applied Physics. Vol.41 Part 1, No.5B. 3163-3167 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.MATSUKAWA et al.: "Ultrasonic wave properties in the particle compounded agarose gels"Ultrasonics. Vol.40. 323-327 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 佐々木一人他: "微粒子混合ゲル中の超音波伝搬-懸濁液中の音波伝搬理論の適用可能性について-"電子情報通信学会技術研究報告. US2002-21. 19-24 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A.HOSOKAWA: "Ultrasonic wave propagation in water-saturated honeycomb ceramics"Poromechanics II (Proceedings of the Second Biot Conference on Poromechanics, Grenoble). 677-682 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 吉野信之他: "人工膝関節手術の軟部組織バランス測定器の開発"日本臨床バイオメカニクス学会誌. Vol.23. 191-195 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西浦 淳他: "射出成形機を用いて作製したPVA-Hの生体内安定性評価"日本臨床バイオメカニクス学会誌. Vol.23. 305-309 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.OTANI: "Acoustic properties of cancellous bone and evaluation of bone density"Journal Revista de Acustica. Vol.XXXIII. ULT-01-016 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大谷隆彦: "骨粗鬆症の進行と超音波の応答"Osteoporosis Japan. Vol.11(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuki IWASAKI et al.: "Changes in trabecular architecture of osteoporotic bone(in Japanese)"Journal of Japanese Society for Clinical Biomechanics and Related Research. 20. 225-229 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Physical Principles and Theoretical Concepts of Transient Acoustic Field"Japanese Journal of Applied Physics. 39, Pt.1, No.5B. 2888-2897 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masatoshi SATO et al.: "Analysis of load propagation mechanisms in compacts of granules with fair amount of water(in Japanese)"Journal of the Society of Materials Science of Japan. 49, No.6. 611-616 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yukihisa FUKUDA et al.: "Impact load transmission of the knee joint (2nd report)(in Japanese)"Journal of Japanese Society for Clinical Biomechanics and Related Research. 21. 205-210 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takunan ESAKA et al.: "Mechanical properties of osteoporotic bone II(in Japanese)"Journal of Japanese Society for Clinical Biomechanic and Related Research. 21. 449-454 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. FUKUDA et al.: "Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage"Clinical Biomechanics. 15. 516-521 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Transient response of the acoustic focusing field(in Japanese)"Technical Report of the Institute of Electronics Information and Communication Engineers. US2000-96. 27-34 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Transient response of the acoustic focusing field"Journal of the Marine Acoustics Society of Japan(in Japanese). 28, No.3. 139-146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. SATO et al.: "Compaction behavior of granules for semi-dry press forming obtained with a stirring granulator"Materials Science for the 21st Century (The Society of Materials Science, Japan). B. 107-116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Atsushi MITSUNARI et al.: "Mechanical study of femoral neck fracture (3rd report) ― Fracture behavior of cancellous bone under shear ―"Journal of Japanese Society for Clinical Biomechanics and Related Research. 22. 265-268 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. WATANABE et al.: "Prediction of mechanical properties of healing fracture using acoustic emission"Journal of Orthopaedic Research. 19, No.4. 548-553 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshinobu WATANABE et al.: "Factors affecting the periods of maturation of callus during the distraction osteogenesis ― Mechanical assessment based on the acoustic emission technology ―"Journal of the Japanese Association of External Fixation and Limb Lengthening. 12. 87-93 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Ultrasonic wave propagation characteristics(in Japanese)"Osteoporosis Japan. 9, no.4. 630-636 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. MATSUKAWA et al.: "Application of a Suspension Theory to Particle-Dispersed Agarose Gels"Japanese Journal of Applied Physics. 41, Part 1, No.5B. 3163-3167 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. MATSUKAWA et al.: "Ultrasonic wave properties in the particle compounded agarose gels"Ultrasonics. 40. 323-327 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuto SASAKI et al.: "Ultrasonic wave propagation in the particle compounded gels― Applicability of Urick's theory in suspensions ―(in Japanese)"Technical Report of the Institute of Electronics Information and Communication Engineers. US2002-21. 19-24 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nobuyuki YOSHINO et al.: "Development of soft-tissue balancer for total knee arthroplasty(in Japanese)"Journal of Japanese Society for Clinical Biomechanics and Related Research. 23. 191-195 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jun NISHIURA et al.: "Evaluation of Biostability of PVA-H shaped by injection modeling method(in Japanese)"Journal of Japanese Society for Clinical Biomechanics and Related Research. 23. 305-309 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. OTANI: "Acoustic properties of cancellous bone and evaluation of bone density"Journal Revista de Acustica, (Biomedical ultrasonics). XXXIII. ULT-01-016 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko OTANI: "Progress of osteoporosis and ultrasonic wave response(in Japanese)"Osteoporosis Japan. 11, in print. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A. HOSOKAWA: "Ultrasonic wave propagation in water-saturated honeycomb ceramics, Poromechanics II (Proceedings of the Second Biot Conference on Poromechanics, Grenoble)"A. A. Balkema Publishers. 677-682 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大谷隆彦: "集束音場のパルス応答"海洋音響学会誌. 28巻3号. 139-146 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光成淳史, 坂口一彦 他: "大腿骨頚部骨折の生力学的研究(第3報) -海綿骨のせん断破壊特性-"日本臨床バイオメカニクス学会誌. 22巻. 265-268 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.MATSUKAWA et al.: "Ultrasonic wave velocity and attenuation in the particle compounded hydrogels"Japanese Journal of Applied Physics, Part 1. Vol.41 No.5B(掲載予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.WATANABE, S.TAKAI et al.: "Prediction of mechanical properties of healing fracture using acoustic emission"Journal of Orthopaedic Research. Vol.19 No.4. 548-553 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 渡部欣忍, 高井信朗 他: "延長仮骨の成熟期間に影響を与えた因子 -AE法による骨癒合評価をもとに-"日本創外固定・骨延長学会雑誌. 12号. 87-93 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 細川篤: "ハニカムセラミックス中の超音波伝搬 -第二種の波動に関する検討"日本音響学会講演論文集. 2巻. 1129-1130 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.SATO, H.SHIOMI: "Compaction Behavior of Granules for Semi-Dry Press Forming Obtained with a Stirring Granulator"Materials Science for the 21st Century. Vol.B. 107-110 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahiko OTANI: "Physical Principles and Theoretical Concepts of Transient Acoustic Field"Jpn.J.Appl.Phys.. Vol.39,Pt.1 No.5B. 2888-2897 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大谷隆彦: "集束音場のパルス応答"電子情報通信学会技術研究報告. US2000-96. 27-34 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 江坂拓南,岡正典,坂口一彦 他: "骨粗鬆症海綿骨の力学的特性に関する研究(第2報)"日本臨床バイオメカニクス学会誌. 21巻. 449-454 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.FUKUDA,S.TAKAI et al: "Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage."Clin.Biomech.. Vol.15. 516-521 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 福田幸久,高井信朗 他: "膝関節の衝撃伝達機構に関する力学的研究(第2報)"日本臨床バイオメカニクス学会誌. 21巻. 205-210 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤昌利,中野達明,塩見治久: "水分を多く含む顆粒を用いたプレス成形体の圧力伝達機構の解析"材料. 49巻・6号. 611-616 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 細川篤,岩佐陽介: "多孔性セラミックス中の超音波伝搬"日本音響学会講演論文集. 3月. 1019-1020 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 秋本忠輝,松川真美 他: "粒子混合ゲル中の超音波伝搬特性"日本音響学会講演論文集. 3月. 933-934 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 今泉邦雄、大谷、須崎: "海綿骨内の間隙内流体成分の超音波伝搬特性の及ぼす影響"日本音響学会講演論文集. 3月. 903-904 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 今泉邦雄、大谷、須崎: "海綿骨中の超音波伝搬における波形とスペクトル成分"日本音響学会講演論文集. 3月. 905-906 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎祐喜、坂口、岡、速水、中村: "骨粗鬆症海綿骨の骨梁構造変化に関する研究(第二報)"日本臨床バイオメカニクス学会誌. 20巻. 225-229 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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