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Creative functional conversion of food resources with poor utility into alternative medical foods

Research Project

Project/Area Number 11794007
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field 食品科学・栄養科学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUMOTO Kiyoshi  Faculty of A griculture, KYUSHU UNIVERSITY, Professor, 大学院・農学研究院, 教授 (80038322)

Co-Investigator(Kenkyū-buntansha) UEZONO Keiko  Institute of Health Science, KYUSHU UNIVERSITY, Associate Professor, 健康科学センター, 助教授 (00168618)
TERAHARA Norihiko  Minami-Kyushu Univ., Faculty of Horticulture., 園芸学部, 教授 (60155471)
KAWASAKI Terukazu  Kyushu Sangyo Univ., Center of Health and Sports Science, Professor, 健康・スポーツ科学センター, 教授 (00038704)
MATSUI Toshiro  Faculty of Agriculture, KYUSHU UNIVERSITY, Associate Professor, 大学院・農学研究院, 助教授 (20238942)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 2001: ¥8,100,000 (Direct Cost: ¥8,100,000)
KeywordsHypertenstion / Diabetes / Functional food design / adult disease
Research Abstract

1. Postprandial suppression of blood glucose level (BGL) by anthocyanins.
In order to optimize the postprandial BGL by food components for the prophylaxis of diabetes, various plants rich in authocyanins were investigated with respect to α-glucosidase (AGH) inhibition. As a result of in vitro screening on AGH inhibition, Ipomoea batatas cv Yamagawamurasaki purple sweet potato (YGM) had a potent maltase inhibition with the IC50 value of 0. 26 mg/ml. The YGM extract also showed a potent in vivo supressive effect of BGL after single oral administration of maltose in SD rats. As a result of isolation of active compound in YGM, acylated anthocyanins were found to show a potent AGH (maltase) inhibitory activity.
2. Depressor mechanism of ACE inhibitory peptide (IVY) derived from wheat germ hydrolysate.
In order to elucidate the depressor effect of Ile-Val-Tyr (IVY) isolated from wheat germ hydrolysate, in vivo ****hypertensive effect of it in SHR was primarily investigated. After intravenous ad … More iminstration of IVY (5mg/kg), a significant (P<0. 05) blood pressure (BP) reduction was observed at 8 min (ΔMBP=19. 2 mmHg), and the reduction was held for 20 min. By using rat and human plasma. IVY was found to be metabolized by the action of aminopeptidases in plasma to form a subsequent ACE inhibitor with hypotensive effect, VY. Thus, the intake of IVY or wheat germ hydrolysate would serve in reguating BP by the combined depressor effect of IVY and VY, after absorption.
3. latent antihypertensive effect of buckwheat (BW) protein.
Latent production of ACE inhibitors from tartary BW, and the characterization of peptides responsible fcr ACE inhibition were investigated. Sequential digestion with pepsin, trypsin and chymotrypsin resulted in a significant increase of ACE inhibitory activity (IC50 ; 0. 14 mg-protein/ml). rutin did not show the ACE inhibition. About 30 mmHg of BP reduction in SHR was observed after single oral adiministration of BW digest at 4 h. From the BW digest, 11 peptides were identified as an ACE inhibitor. The findings in this study demonstrated that BW protein had a latent ability to exert an in vivo antihypertensive effect after the gastrointestinal digestion process. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] T.Matsui, et al.: "Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action"Bioscience, Biotechnology, and Biochemistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Matsui, et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins(1)"Journal of Agricultural and Food Chemistry. 49・4. 1948-1951 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Matsui, et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins(2)"Journal of Agricultural and Food Chemistry. 49・4. 1952-1956 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Matsui, et al.: "Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein"Journal of Peptide Science. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Matsui, et al: "Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma"Biological and Pharmacological Bulletin. 23・4. 427-431 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Matsui, M. Kobayashi, S. Hayashida, and K. Matsumoto: "Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action."Biosci. Biotechnol. Biochem.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.-H. Li, T. Matsui, K. Matsumoto, R. Yamasaki, and T. Kawasaki: "Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein."J. Peptide Sci.. (in accept).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Matsui, T. Ueda, T. Oki, K. Sugita, N. Terahara, and K. Matsumoto: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity"J. Agric. Food Chem.. 49(4). 1948-1951 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Matsui, T. Ueda, T. Oki, K. Sugita, N. Terahara, and K. Matsumoto: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 2. α-Glucosidase Inhibition by Isolated Acylated Anthocyanins."J. Agric. Food Chem.. 49(4). 1952-1956 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Matsui, C.-H. Li, T. Tanaka, T. Maki, Y. Osajima, and K. Matsumoto.: "Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma."Biol. Pharm. Bull.. 23(4). 427-431 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Matsui et al.: "Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action"Bioscience, Biotechnology, and Biochemistry. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Matsui et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins(1)"Journal of Agricultural and Food Chemistry. 49・4. 1948-1951 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Matsui et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins(2)"Journal of Agricultural and Food Chemistry. 49・4. 1952-1956 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Matsui et al.: "Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein"Jounal of Peptide Science. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Matsui et al.: "Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma."Biological and Pharmacological Bulletin. 23巻4号. 427-431 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Matsui et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins(1)"Journal of Agricultural and Food Chemistry. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Matsui et al.: "α-Glucosidase Inhibitory Action of Natural Acylated Anthocyains(2)"Journal of Agricultural and Food Chemistry. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Toshiro Matsui: "Depressor Efect of Wheat Germ Hydrolysate and the Metabolizm in Rat and Human Plasma"Biological and Pharmacological Balletin. 23巻4号(掲載予定). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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