| Project/Area Number |
11794028
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| Research Category |
Grant-in-Aid for University and Society Collaboration
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| Allocation Type | Single-year Grants |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
ANIYA Yoko Faculty of Medicine Professor, 医学部, 教授 (90045055)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIBA Toshio Okinawa Industrial Technology Center, Research and Development Division, Chief of the Division, 研究開発部, 主任研究員
TAKAMINE Husae Faculty of Medicine Associate Professor, 医学部, 助教授 (80045062)
NOGUCHI Katsuhiko Faculty of Medicine Associate Professor, 医学部, 助教授 (70156181)
長嶺 勝 琉球大学, 遺伝子実験施設, 助教授 (20189161)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2001: ¥12,600,000 (Direct Cost: ¥12,600,000)
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| Keywords | medicinal herb / Okinawa / reactive oxygen species / antioxidants / hepatoprotection / bactericidal action / ischemia / reperfusion / quercetin / 薬草 / 抗酸化作用 / iNOS / モモタマナ / タンニン / 抗菌作用 / 虚血再灌流障害 / フラボノイド / ベニバナボロギク / 健康食品 / グァバ |
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| Research Abstract |
Since reactive oxygen species (ROS) are contributed to pathogenesis of various diseases antioxidants which can scavenge ROS are expected to prevent ROS-related disorders. In the present study antioxidant action of selected Okinawan medicinal herbs which have been used as folk medicine or edible plants was evaluated. As antioxidants, isochlorogenic acid, quercetin 3-galactoside, quercetin 3-glucoside, catechin, quercitrin and chlorogenic acid from Crassocephalum crepidioides, corilagin and chebulagic acid from Terminalia catapa, chlorogenic acid, quercetin 3-rhamnoside and quercetin 3-glucoside from Peucedanum japonicum were isolated. C.ctepidioides and Lanonium wrightii showed hepatoprotective action against carbon tetrachloride -induced liver injuries. Psidium guajava and L. wrightii as well as quercetin and gallic acid depressed ischemia/reperfusion disorders of isolated rat hearts. T. catapa and its antioxidant components showed strong bactericidal activity against various bacteria including methicillin-highly resistant S. aureus. P. japonicum and some antioxidant components also showed an inhibition of nitric oxide formation from macrophages. Thus it was suggested that these medicinal herbs with antioxidant action are beneficial for development of health promoting materials.
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