| Project/Area Number |
11794032
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| Research Category |
Grant-in-Aid for University and Society Collaboration
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Akita University |
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Principal Investigator |
SUGIYAMA Toshihiro Akita University, School of Medicine, Professor, 医学部, 教授 (00127242)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Kunihiko Akita University, School of Medicine, Associate Professor, 医学部, 助教授 (60197796)
KATO Yukio Hiroshima University, School of Dentistry, Professor, 歯学部, 教授 (10112062)
MANABE Motomu Akita University, School of Medicine, Professor, 医学部, 教授 (30138309)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2001: ¥14,500,000 (Direct Cost: ¥14,500,000)
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| Keywords | Tissue Engineering / Liver regeneration / Stem Cells / Cultured skin / Shh / Mesenchyme / Bone regeneration / フィーダー細胞 / ケラチノサイト / 肝臓幹様細胞 / 毛幹細胞 / 骨髄間葉系細胞 / 骨再生 / 毛再生 / 発毛促進 |
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| Research Abstract |
On this research, we tried to develop new technologies to regenerate the liver, skin-hair, and cartilagebone from the adult tissue stem cells.
1. Liver. We established several cell clones from the liver epithelium and succeeded to induce the differentiation of them to the hepatocytes in vitro. We also tried and partially succeeded to recover the liver function on the experimental animals by using these cells.
2. Skin-Hair. We developed a new-technology to accelerate the formation of the cultured epithelium by using Sonic hedgehog expressing feeder cells. This result indicates that the application of the knowledge from the molecular biology is useful to develop the tissue engineering.
3. Mesenchyme. We obtained mesenchymal stem cells from the human bone marrow and succeeded to differentiate them to the osteoblast, chondrocytes, and adipocytes. We are trying to apply these cells to the plastic surgery.
The connective research among regions was very powerful and useful for the combined and prompt research.
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