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Molecular epidemiology of acute coronary syndrome in Japan : Large-scale, prospective, multicenter clinical investigation

Research Project

Project/Area Number 11794035
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

HORI Masatsugu  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (20124779)

Co-Investigator(Kenkyū-buntansha) SATO Hiroshi  Osaka University Graduate School of Medicine, Assistant professor, 医学系研究科, 助手 (10294092)
SATO Hideyuki  Osaka University Graduate School of Medicine, Assistant professor, 医学系研究科, 助手 (70167435)
TAKEDA Hiroshi  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (20127252)
MATSUMURA Yasushi  Osaka University Hospital, Associate Professor, 医学部附属病院, 助教授 (90252642)
葛谷 恒彦  大阪大学, 医学系研究科, 助教授 (80150340)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥18,300,000 (Direct Cost: ¥18,300,000)
Fiscal Year 2001: ¥18,300,000 (Direct Cost: ¥18,300,000)
KeywordsAcute myocardial infarction / Large-scale, prospective, multicenter clinical investigation / DNA bank / Serum Bank / 多施設共同大規模臨床検査 / DNA-バンク
Research Abstract

In 2000, we performed (1) to examine the predictors of in-hospital mortality alter acute myocardial infarction, (2) to investigate the association between Chlamydia pneumoniae IgG and/or IgA antibodies and the onset of acute myocardial infarction and joint effects of Chlamydia pneumoniae infection and classic coronary risk factors on risk of acute myocardial infarction, and (3) to clarify genetic background in the pathogenesis of acute myocardial infarction.
(1) Predictors of in-hospital morality alter acute myocardial infarction
We showed that collateral vessel influences better in-hospital mentality and its effect is modified by aging, diabetes mellitus, and preinfarction angina.
(2) The effect of Chlamydia pneumoniae infection on the onset of acute myocardial infarction
We showed that the predictive value of Chlamydia pneumoniae IgA antibody titer for acute myocardial infarction is only weakly positive and of marginal statistical significance. However, the joint effects of high C pneumoniae IgA antibody titers together with classic coronary risk factors such as obesity, hypercholesterolemia, and smoking are greater.
(3) The association between genetic background and the pathogenesis of acute myocardial infarction
We performed a genome-wide association study using the high-throughout multiplex PCR-Invader assay method at 92,788 randomly selected gene-based singe-nucleotide polymorphisms (SNPs). We found that two SNPs were significantly associated with acute myocardial infarction. We are now making a dense SNP map of this locus for linkage disequilibrium mapping, followed by functional analyses of gene products.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Ohnishi Y: "A high-throughput SNP typing system for genome-wide association studies"Journal of Human Genetics. 46. 471-477 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinjo K: "Circadian variation of the onset of acute myocardial infarction in the Osaka area, 1998-1999: characterization of morning and nighttime peaks"Japanese Circulation Journal. 65. 617-620 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwakura K: "Predictive factors for development of the no-reflow phenomenon in patients with reperfused anterior wall acute myocardial infarction"Journal of American College of Cardiology. 38. 472-477 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sanada S: "Cardioprotective effect afforded b transient exposure to phosphodiesterase III inhibitors : role of protein kinase A and p38 mitogen-activated protein kinase"Circulation. 104. 705-710 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohnishi Y: "A high-throughput SNP typing system for genome-wide association studies"Journal of Human Genetics. 46. 471-477 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinjo K: "Circadian variation of the onset of acute myocardial infarction in the Osaka area, 1998-1999 : characterization of morning and nighttime peaks"Japanese Circulation Journal. 65. 617-620 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwakura K: "Predictive factors for development of the no-reflow phenomenon in patients with reperfused anterior wall acute myocardial infarction"Journal of American College of Cardiology. 38. 472-477 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sanada S: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors : the role of protein kinase A and p38 mitogen-activated protein kinase"Circulation. 104. 705-710 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohnishi Y: "A high-throughput SNP typing system for genome-wide association studies"Journal of Human Genetics. 46. 471-477 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 南都伸介: "勤労者の心疾患の臨床的特長-特に急性心筋梗塞を対象として-"日本職業・災害医学会会誌. 48. 192-196 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kinjo K: "Circadian variation of the onset of acute myocardial infarction in the Osaka area,1998-1999:characterization of morning and nighttime peaks"Japanese Circulation Journal. 65. 617-620 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 南都伸介: "勤労者の心疾患の特徴-急性冠症候群研究会(OACIS)データからの急性心筋梗塞症における解析-"日本職業・災害医学会会誌. 49. 57-60 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Iwakura K: "Predictive factors for development of the no-reflow phenomenon in patients with reperfused anterior wall acute myocardial infarction"Journal of American College Cardiology. 38. 472-477 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sanada S: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors : the role of protein kinase A and p38 mitogen-activated protein kinase"Circulation. 104. 705-710 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohnishi,Y: "Identification of 187 single nucleotide polymorphism among 41 candidate genes for ischemic heart disease in Japanese populations"Human Genetics. 106. 288-292 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kitakaze,M: "Nifidioine-induced coronary vasodilation in ischemic hearts is attribute to bradkinin and NO-dependent mechanisms in dogs."Circulation. 101. 311-317 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 金城都博: "本邦における急性心筋梗塞の概日リズムの特徴と背景因子"日本循環器病学会抄録集. 64. 193 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 塩谷一成: "本邦における急性心筋梗塞の週内変動"日本循環器学会抄録集. 64. 193 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 塩谷一成: "心筋梗塞後のうつ症状と心血管イベントについての検討"日本循環器病学会抄録集. 64. 589 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 金城都博: "ダイレクトPTCAを施行した急性心筋梗塞における虚血性イベントの予測因子としてのCRPの役割"日本心臓病学会抄録集. 362. 413 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大西洋三: "Identification of 187 Single Nucleotide Polymorphisms among 41 Candidate Genes for Ischemic Heart Disease In Japanese Population"Human Genetics. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒飛俊哉: "冠危険因子と急性心筋梗塞の院内予後の性差についての検討"日本心臓病学会. 34巻. 404 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒飛俊哉: "高齢者急性心筋梗塞に対するdirect PTCAの有効性と安全性"日本心臓病学会. 34巻. 283 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 塩谷一成: "急性心筋梗塞患者の復識状況とその阻害因子"日本心臓病学会. 34巻. 270 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒飛俊哉: "急性心筋梗塞患者の急性期予後規定因子-来院時心電図についての検討"日本循環器病学会. 63巻. 189 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 塩谷一成: "A Unique Business Custom Triggers Myocardial Infarction Under Economic Recession"American Heart Association. 100巻・18号. 851 (1990)

    • Related Report
      1999 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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