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Study of brain plasticity during intensive training in stroke patients

Research Project

Project/Area Number 11835025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionKagoshima University

Principal Investigator

ETOH Seiji  Faculty of Medicine, Kagoshima University, Research Associate, 医学部, 助手 (70295244)

Co-Investigator(Kenkyū-buntansha) TANAKA Nobuyuki  Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (40041454)
OGATA Atuko  University Hospital, Faculty of Medicine, Kagoshima University, Research Associate, 医学部・附属病院, 助手 (40305123)
KAWAHIRA Kazumi  Faculty of Medicine, Kagoshima University, Associate Professor, 医学部, 助教授 (20117493)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsstroke / transcranial magnetic stimulation / intensive training / hemiplegia
Research Abstract

The mechanisms which leads to recovery of motor function after a stroke are poorly understood. We need the development of the technique of rehabilitation to the hemiplegic arm in stroke patients. Change of amplitude of motor evoked potential(MEP) is thought to be one of the factors which may contribute to recovery. We have investigated the change of MEPs in stroke patients during conventional and intensive training. The subjects were 27 patients with hemiplegia due to stroke (55.1±13.4 years old, 15.1±12.7 weeks after onset). They received intensive training of the himiplegic upper limbs for 2 to 6 weeks in addition to the basic conventional training for 2 weeks. After training, Uedas grade and Brunnstrom stage were improved. Focal transcranial magnetic stimulation(TMS) to the pollicis abductor brevis was followed up by evaluating amplitude of MEPs in 12 patients. The affected hemisphere was marked out over the central area in a 1cm or 2cm grid. TMS were given to 10 to 20 points using a figure-of-eight coil to elicit MEPs in contralateral abductor pollicis brevis muscle. The amplitudes of MEPs were measured peak-to-peak on each hemisphere at rest or under weak voluntary contraction. Based on the change of am plitude of MEP, 12 patients were devided into 3 groups, 1) decreased MEP amplitude group (1 case), 2) increased MEP amplitude group (4 cases), 3) no changed MEP amplitude group (7 cases). In decreased MEP group, the patient recoverd to the level of Brunnstrom stage V I.In increased MEP group, the patients recovered to the level of Brunnstrom stage I V or V.In no changed MEP group, the patients recovered to the level of Brunnstrom stage V or V I.Functional outcome of decreased and no changed MEP group was better than that of increased MEP group. These results suggests any relationship between the cortical excitability and the functional recovery after stroke.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 衛藤誠二: "脳卒中片麻痺上肢訓練時の経頭蓋骨磁気刺激による運動誘発電位の変化"リハビリテーション医学. 37巻12号. 925-933 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Seiji Etoh: "The change of motor evoked potentials during training of hemiplegic hand in stroke patients"Japanese Journal of Rehabilitation Medicine. vol 37. 925-933 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 衛藤誠二: "脳卒中片麻痺上肢訓練時の経頭蓋磁気刺激による運動誘発電位の変化"リハビリテーション医学. 37巻12号. 925-933 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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