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Dynamics of memory state of the brain

Research Project

Project/Area Number 11837016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionKyushu Institute of Technology

Principal Investigator

HAYASHI Hatsuo  Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Professor, 大学院・生命体工学研究科, 教授 (00108664)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsHippocampus / CA3 and CA1 regions / Periodic stimulation / Field potential responses / Synaptic plasticity / Multi-recording / Chaos / Dynamics / CA3領野の周期刺激 / CA1領野の電場電位応答 / 時空応答 / CA3領野の自発リズム
Research Abstract

In this research project, long-term potentiation (LTP) at synapses in the rat hippocampus followed by spontaneous bursting discharges was induced and dynamical features of the responses of the hippocampal CA3 and CA1 regions to periodic stimulation were investigated, (l) LTP at afferent synapses to CA3 did not contribute to generate the spontaneous activity of CA3 but LTP at recurrent excitatory synapses in CA3 did. (2) The CA3 region where LTP was induced in recurrent excitatory circuits caused phase-locked and chaotic responses to periodic mossy fiber stimulation. (3) LTP can be induced in a local area of the CA3 region. The local area was maintained even if LTP was enhanced and resulted in spontaneous epileptiform bursts. The local area might correspond to a memory state. (4) The excitatory pathway from contralateral CA3 to CA1 via ipsilateral CA3 was augmented by tetanic stimulation of the contralateral CA3, while the direct pathway from the contralateral CA3 to CA1 was not. (5) Field potential responses of CA1 to periodic stimulation of ipsilateral CA3 depend on the stimulus frequency; the feature of the responses to 20 40 Hz stimulation changes dramatically with time. The negative field potential after an initial transient especially caused phase-locked and chaotic responses. This results from the dynamical features of CA3.
The above results conclude that the CA3 region, which has rich recurrent excitatory connections, causes phase-locked and chaotic responses to periodic stimulation when LTP is induced in CA3, and those activities are projected to CA1 excitatory through Schaffer collaterals and inhibitory through interneurons.

Report

(3 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] K.Nakashima, H.Hayashi, S.Ishizuka: "Spontaneovs epileptiform bursts induced in different regions of rat longitudinal CA3 slices by mossy fiber stimulation ---"Proceedings of the 3rd International Workshop on Neural Coding. 79-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Hinayasumi, H.Shiraishi, K.Nakashima, H.Hayashi: "Temporal change of the spatial distribution of the hippocampal CA1 response to periodic hippocampal CA3 stimulation"Proceedings of the 3rd International Workshop on Neural Coding. 147-150 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Nakashima, H.Hayashi, S.Ishizuka: "LTP-induced synchronous activity of CA3 is stably localized by feed-forward and recurrent inhibition ---"Proceedings of the 7th International Conference on Neural In formation Processing. 1. 55-58 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Nakashima, H.Hayashi, O.Shimizu, S.Ishizuka: "Long-term change in synaptic transmission in CA3 circuits followed by spontaneons fhythmic activity in rat hippocampal ---"Neuroscience Research. 30. 325-336 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Nakashima, T.Umemura, H.Hayashi, S.Ishizuka: "Frequency dependence of the spatial pattern of synchronized activity in rat hippocampus in vivo and in vitro"Proceedings of the International Enference on Neural Information Processing. 1. 9-13 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Nakashima, H. Hayashi and S. Ishizuka: "Spontaneous epileptiform bursts induced in different regions of rat longitudinal CA3 slices by mossy fiber stimulation at different site"Proceedings of the 3rd International Workshop on Neural Coding. 79-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Hinayasumi, H. Shiraishi, K. Nakashima, H. Hayashi and S. Ishizuka: "Temporal change of the spatial distribution of the hippocampal CA1 response to periodic hippocampal CA3 stimulation"Proceedings of the 3rd International Workshop on Neural Coding. 147-150 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Nakashima, H. Hayashi and S. Ishizuka: "LTP-induced synchoronous activity of CA3 is stably localized by feed-forward and recurrent inhibition in longitudinal rat hippocampla slices"Proceedings of the 7th International Confarence on Neural Information Processing. Vol.1. 55-58 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Nakashima, H. Hayashi, O. Shimizu and S. Ishizuka: "Long-term change in synaptic transmission in CA3 circuites followed by spontaneous rhythmic activity in rat hippocampal slices"Neuroscience Research. Vol.30. 325-336 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Nakashima, T. Umemura, H. Hayashi and S. Ishizuka: "Frequency dependence of the spatial pattern of synchronized activity in rat hippocampus in vivo and in vitro"Proceedings of the International Conference on Neural Information Processing. Vol.1. 9-13 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中島孔志,林初男,石塚智: "ラット海馬CA3縦断面スライスに苔状線維高頻度刺激で起こしたリズムとペニシリンで起こしたリズムの時空活動の違い。"第23回日本神経科学大会第10回日本神経回路学会合同大会講演論文集. 300 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Nakashima,H.Hayashi and S.Ishizuka: "LTP-induced synchronous activity of CA3 is stably localized by feed-forward and recurrent inhibition"Proceedings of the 7th International Conference on Neural Information Processing. vol1. 55-58 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中島 孔志 他: "苔状線維局所刺激によりラット海馬CA3縦断面スライスの2つの局所領域に生じた自発性てんかん様バーストリズムとLTPの分布"日本神経回路学会講演論文集. 85-86 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 日南休 泰明 他: "ラットの海馬CA3領域の周期刺激に対する海馬CA1領域の応答の空間分布とその時間変化"日本神経回路学会講演論文集. 132-133 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中島 孔志 他: "CA3錐体細胞相間の興奮性シナプスのLTPと自発性のてんかん様バースト"日本生物物理学会講演予稿集. s56-s56 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koushi Nakashima 他: "Spontaneous epileptiform bursts induced in different regions of rat longitudinal CA3 slices by mossy fiber stimulation at different sites"Proceedings of a the 3rd International Workshop on Neural Coding. 79-82 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yasuaki Hinayasumi 他: "Temporal change of the spatial distribution of the hippocampal CA1 response to periodic hippocampal CA3 stimulation"Proceedings of the 3rd International Workshop on Neural Coding. 147-150 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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