| Project/Area Number |
11838005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | Gifu University |
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Principal Investigator |
KOZAWA Osamu Gifu University, School of Medicine, Associate professor, 医学部, 助教授 (90225417)
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| Co-Investigator(Kenkyū-buntansha) |
UEMATSU Toshihiko Gifu University, School of Medicine, Professor, 医学部, 教授 (50151832)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | platelet / heat shock protein / vascular smooth muscle / aggregation / 凝集 |
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| Research Abstract |
We investigated the effects of p20, a low molecular weight heat shock protein, on platelet aggregation and the mechanism. We obtained the results as follows:
1. p38 mitogen-activated protein kinase is required for vasopressin-stimulated HSP27 induction in vascular smooth muscle cells, and the activation of p38 mitogen-activated protein kinase is dependent on protein kinase C.
2. αB-crystallin, which is discharged from vessel walls in response to endothelial injury, acts intercellularly as a regulator of platelet function. Moreover, these findings could be a part of new concept of antiplatelet therapy in the treatment of cardiovascular diseases.
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