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A new detection system for artificial synthetic steroid like compound using KO mouse lacking estrogen.

Research Project

Project/Area Number 11839016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionKochi Medical School

Principal Investigator

SHIZUTA Yutaka  Kochi Medical School, Dept.Medical Chemistry, Professor, 医学部, 教授 (50025631)

Co-Investigator(Kenkyū-buntansha) KUGE Hideaki  Kochi Medical School, Dept.Medical Chemistry, Research Associate, 医学部, 助手 (70304673)
TODA Katsumi  Kochi Medical School, Dept.Medical Chemistry, Adjunct Professor, 医学部, 助教授 (40197893)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsestrogen / biohazard estrogen / a new assay method / KO mouse
Research Abstract

To establish a new detection system for harmful estrogen like chemical compounds. KO mouse lacking estrogen have been prepared. This female mouse becomes infertile due to immature ovary and uterus and they decay after growth but at becomes fertile when the mouse is supplement with estrogen directly birth. Many kind of estrogen analogs competitive action of estrogens to the mouse again those organs. The male mouse is also fertile due to abnormal sexual behavior, but it becomes fertile after supplemented with estrogen. It also lacks aggression against other male mouse. This is reversed by supplementation with estrogen, and the action of estrogen is inhibited by many estrogens analogs. Thus, KO mouse lacking estrogen prepared in this study is useful for bioassay of biohazard estrogen like chemical substances. We have also developed chemical assay method for harmful estrogen like stubstances in the brain of the mouse before and after estrogen treatment.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report

Research Products

(15 results)

All Other

All Publications

  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2000 Final Research Report Summary
  • [Publications]

    • Related Report
      2000 Annual Research Report
  • [Publications]

    • Related Report
      2000 Annual Research Report
  • [Publications]

    • Related Report
      2000 Annual Research Report
  • [Publications]

    • Related Report
      1999 Annual Research Report
  • [Publications]

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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