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Evaluation of the effects of endocrine disruptors in synthetic compounds on several biological organisms.

Research Project

Project/Area Number 11839026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionNIHON UNIVERSITY

Principal Investigator

KIMURA Junpei  College of Bioresource Sciences, Nihon University, Associate Professor., 生物資源科学部・獣医学科, 助教授 (30177919)

Co-Investigator(Kenkyū-buntansha) ASAHINA Kiyoshi  College of Bioresource Sciences, Nihon University, Professor., 生物資源科学部, 教授 (10147671)
INOUE Tadashi  College of Bioresource Sciences, Nihon University, Professor., 生物資源科学部, 教授 (90124213)
KATASE Takao  College of Bioresource Sciences, Nihon University, Professor., 生物資源科学部, 教授 (70070696)
MORITOMO Tadaaki  College of Bioresource Sciences, Nihon University, Assistant, 生物資源科学部, 講師 (20239677)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsendocrine disruptor / smear test / plastic / nonylphenol / estrogenic activity / フタル酸エステル / ビスフェノールA / 内分泌撹乱物質 / 膣前庭 / 組換え酵母検出系 / プラスチック製品 / エストロゲン / コルチゾル
Research Abstract

The estrogenic activity of thirty seven endocrine disruptors including byproducts from plastic gloves and food wraps, and chemicals related to nonylphenol, medical drugs and phytoestrogens, were measured by in vitro and in vivo tests. There was a good correlation between the results obtained from two in vitro tests which included a recombinant yeast test and a cultured mammary cancer cell test. Eighteen chemicals were subjected to an in vivo rat vaginal smear test. Those of the chemicals subjected, eight showed a positive correlation between results obtained from the present study and the results from Dodds's results (1938). From these correlation, the evaluation methods of plastic compounds, medical drugs and phytoestrogens in food safety and living environment were discussed.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 片瀬隆雄: "内分泌かく乱物質研究の最前線"季刊化学総説. 50. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Kimura et al.: "The Application of a Three-dimensional Internal Structure Microscopy (3D-ism) in the Observation of Mare Ovary"Anatomia Histologia Embryologia. (In press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Kimura et al.: "Immunohistochemical Localization of Inhibin and Steroidogenic Enzymes in the Ovary of Common Tree Shrew and Northern Smooth-tailed Tree Shrew"Anatomia Histologia Embryologia. 29. 267-271 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Kimura et al.: "The Application of a Three-dimensional Internal structure Microscopy (3D-ism) in the Observation of Mare Ovary"Anatomia Histologia Embryologia. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Kimura et al.: "Immunohistochemical Localization of Inhibin and Steroidogenic Enzymes in the Ovary of Common Tree Shrew and Northern Smooth-tailed Tree Shrew."Anatomia Histologia Embryologia. 29. 267-271 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 片瀬隆雄: "内分泌かく乱物質研究の最前線"季刊化学総説. 50. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] J.Kimura et al.: "The Application of a Three-dimensional Internal Structure Microscopy (3D-ism) in the Observation of Mare Ovary"Anatomia Histologia Embryologia. In press. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] J.Kimura et al.: "Immunohistochemical Localization of Inhibin and Steroidogenic Enzymes in the Ovary of Common Tree Shrew and Northern Smooth-tailed Tree Shrew"Anatomia Histologia Embryologia. 29. 267-271 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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