ヒト女性乳癌における男性ホルモン、アンドロゲンの局所産生と作用機序の解明
| Project/Area Number |
11F01735
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
MCNAMARA Keely (2013) 東北大学, 大学院医学系研究科, 助教
笹野 公伸 (2011-2012) 東北大学, 大学院・医学系研究科, 教授
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| Co-Investigator(Kenkyū-buntansha) |
MCNAMARA Keely 東北大学, 大学院・医学系研究科, 外国人特別研究員
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2013: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2012: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Androgen / Breast Cancer / Steroid receptors / breast cancer / androgen / Triple Negative Breast Cancer / アンドロゲン / 受容体 |
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| Research Abstract |
Results of the research above revealed that AR expression in TNBC specimens correlated with lower levels of proliferation and this association was stronger in samples that also expressed enzymes for androgen synthetic pathways. This result was actually contrary to our original hypothesis, based on the research reports from others that groups characterized by very high levels of androgen receptor in the absence of estrogen receptor had a worse prognosis, and is contrary to the results of the dominate group in this area of research. The novelty of this finding was recognized by the research being awarded a prize in the presidential poster competition at the international scientific meeting ENDO2012, lead to an invitation to speak at the 15^<th> International congress on hormonal steroid and hormones & cancer in Kanazawa in 2012 and was subsequently published in the journal cancer science. Since this original contradictory finding we have been searching through possible explanations that reconcile an overall trend showing the pathological analysis reveals the androgen receptor to be a potential suppressor of proliferation, yet cell line and molecular analysis suggesting the androgen receptor as a potential oncogene. Recent data, currently under consideration for publication in the journal breast cancer research and treatment suggests that in triple negative breast cancer there may be at least two distinct types of AR expressing TNBC. In tandem with two recent reports from other groups this may provide important information in patient selection when choosing AR targeting agents as a therapy in TNBC. In addition to this, recent papers suggesting a role of ERβ in breast cancer, combined with the known overlap between androgen receptor and ERβ receptor ligands has led to an expansion of the project to investigate these factors in TNBC.
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| Strategy for Future Research Activity |
(抄録なし)
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Report
(3 results)
Research Products
(20 results)
