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神経性および局所性調節による運動時の相互的循環制御機構の解明

Research Project

Project/Area Number 11J00040
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

渡邊 和仁  筑波大学, 大学院人間総合科学研究科, 特別研究員(DC1)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2013: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2012: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2011: ¥700,000 (Direct Cost: ¥700,000)
Keywords静的ハンドグリップ運動 / 循環反応の個人差 / 筋代謝受容器反射 / 動脈圧受容器反射 / 運動中の経時的変化 / 心臓自律神経活動 / 運動後阻血
Research Abstract

高強度運動時には、筋代謝受容器反射や動脈圧受容器反射といわれる神経性の末梢反射調節や、末梢血管の局所性調節などが複合的に働き血圧や血流を調節するが、これらの循環調節機構がどのような関連を持ち運動時の循環動態を制御しているのかについては解明されていない。本年度においては、動脈圧受容器への負荷が徐々に増加するような継続的な静的ハンドグリップ運動中の循環反応とその調節メカニズムを、個人差を加味して検討することを目的として実験を行った。
健康な男女28名を被験者とし、最大発揮張力の50%での静的ハンドグリップ運動(HG)を15秒、30秒、45秒、60秒または疲労困憊まで行うこととし、血圧(動脈圧受容器への負荷)を多段階に変化させた。また、各HG後に前腕阻血を4分間行うことで筋代謝受容器刺激を行った。測定項目は、動脈血圧、心拍数、心拍出量、総末梢血管抵抗、下肢血流量および下肢血管抵抗とした。運動時の循環反応の個人差を変動係数(CV)により定量するとともに、それらの個人差に筋代謝受容器刺激時の循環反応や血圧変動と心拍数変動から評価する動脈圧受容器反射の感受性(BRS)が関係するか調べた。その結果、運動時間が30秒以上の場合、心拍出量およが総末梢血管抵抗の反応のCVは血圧反応のCVよりも顕著に大きな値を示した。』また、運動時間が60秒以上の場合、心拍出量および総末梢血管抵抗の反応は筋代謝受容器刺激時のそれらの反応との間に正の相関関係がみられたが、筋代謝受容器刺激時のBRSの反応との間に関係はみられなかった。以上のことから、HGを開始しある一定時間経過すると、それ以降は疲労困憊まで心拍出量および末梢血管抵抗の反応に顕著な個人差が生じること、また、疲労困憊に近い状況ではそれらの個人差に筋代謝受容器反射が関与するが、それらの個人差の成因は運動時間によって一様ではなく、他の調節機構も含め複合的に関与する可能性があることが示唆された。

Strategy for Future Research Activity

(抄録なし)

Report

(3 results)
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (23 results)

  • [Journal Article] Individual differences in cardiac and vascular components of the pressor response to isometric handgrip exercise in humans2014

    • Author(s)
      Kazuhito Watanabe, Masashi Ichinose, Rei Tahara and Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: VOL. 306 Issue: 2 Pages: 251-260

    • DOI

      10.1152/ajpheart.00699.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans2013

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe、 Naoto Fujii, Narihiko Kondo and Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: (In press) Issue: 11 Pages: 1568-1575

    • DOI

      10.1152/ajpheart.00833.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans2013

    • Author(s)
      Fujii N. Ichinose M, Honda Y,Tsuji B, Watanabe K, Kondo N & Nishi yasu T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 113 Issue: 1 Pages: 51-62

    • DOI

      10.1007/s00421-012-2413-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular regulation during exercise - Contribution of peripheral reflexes2012

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe Naoto Fujii and Takeshi Nishiyasu
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 3 Pages: 437-445

    • DOI

      10.7600/jpfsm.1.437

    • NAID

      10031158974

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans2012

    • Author(s)
      Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N & Nishiyasu T
    • Journal Title

      Am J Physiol Regul integr Comp Physiol

      Volume: 303 Issue: 9 Pages: R975-R983

    • DOI

      10.1152/ajpregu.00169.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of muscle metaboreflex function through graded reduction in foreann blood flow during rhythmic handgrip exercise in humans2011

    • Author(s)
      Masashi Ichinose, Stephane Delliaux, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: VOL.301 Issue: 2 Pages: 609-616

    • DOI

      10.1152/ajpheart.00076.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 呼吸パターンの違いが中強度一定負荷運動時の酸素摂取量及び心拍数に及ぼす影響―水中巻き足運動時の呼吸特性に着目して―2013

    • Author(s)
      佐々木 洋輔, 高木 英樹, 辻 文, 渡邊 和仁, 村瀬 陽介, 椿本 昇三, 西保 岳
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館・学術総合センター・共立講堂(東京都千代田区)
    • Year and Date
      2013-09-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] 静的ハンドグリップ運動時における心拍出量および末梢血管抵抗の反応の個人差2013

    • Author(s)
      渡邊 和仁, 一之瀬 真志, 田原 麗衣, 西保 岳
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館・学術総合センター・共立講堂(東京都千代田区)
    • Year and Date
      2013-09-21
    • Related Report
      2013 Annual Research Report
  • [Presentation] lndividual differences in cardiac and vascular components of the pressor response to isometric handgrip exercise in humans2013

    • Author(s)
      Kazuhito Watanabe
    • Organizer
      第29回身心統合科学(Body and Mimd Integrated Sciences)セミナー
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Year and Date
      2013-07-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] Individual differences in cardiac and vascular components of the pressor responses to isometric handgrip exercise in humans2013

    • Author(s)
      Kazuhito Watanabe, Masashi Ichinose, Rei Tahara and Takeshi Nishiyasu
    • Organizer
      Experimental biology 2013
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-04-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functions of the endothelial dilation and the reflex from skeletal muscle in badminton players are different between dominant and non-dominant arms2013

    • Author(s)
      Rei Tahara, Kazuhito Watanabe、 Masashi Ichinose, Masashi Suita, Seiji Maeda and Takeshi Nishiyasu
    • Organizer
      15th International Conference on Environmental Ergonomics
    • Place of Presentation
      Queenstown,(New Zealand)
    • Year and Date
      2013-02-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] バドミントン競技選手における血管内皮機能および反射性循環調節に関する研究-利き腕と非利き腕に着目して-2012

    • Author(s)
      田原麗衣, 渡邊和仁, 一之瀬真志, 吹田真士, 前田清司, 西保岳
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自発的過換気による動脈血二酸化炭素分圧低下が高強度間欠的運動時のパフォーマンス及び 呼吸代謝応答に及ぼす影響2012

    • Author(s)
      橋本峻, 辻文, 藤井直人, 渡邊和仁, 西保岳
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 下肢における段階的圧迫タイツ着用が暑熱下運動時の熱放散反応に及ぼす影響2012

    • Author(s)
      辻文, 渡邊和仁, 西保岳
    • Organizer
      第20回日本運動生理学会大会
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Muscle metaboreflex modulates dynamic cardiovascular and cerebrovascular responses to acute hypotension in humans2012

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe Bun Tsuji and Takeshi Nishiyasu
    • Organizer
      The 59th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      San Francisco, Califomia(米国)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of voluntary hypocapnic hyperventilation on thermoregulatory responses in exercising humans2012

    • Author(s)
      Naoto Fujii, Yasushi Honda, Ken Komura, Bun Tsuji, Akira Sugihara, Kazuhito Watanabe, Narihiko Kondo and Takeshi Nishiyasu
    • Organizer
      Experimental biology 2012
    • Place of Presentation
      San Diego, California(米国)
    • Year and Date
      2012-04-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環反応2011

    • Author(s)
      一之瀬真志, 渡邊和仁, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋代謝受容器反射活性時における動脈圧受容器反射による心拍調節機能:活動部位の違いに着目して2011

    • Author(s)
      渡邊和仁, 一之瀬真志, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 安静加温時における動脈血圧反応と換気亢進反応との関係2011

    • Author(s)
      藤井直人, 一之瀬真志, 辻文, 渡邊和仁, 近藤徳彦, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] The influence of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans2011

    • Author(s)
      Naoto Fujii, Yasushi Honda, Stephane Delliaux, Bun Tsuji, Kazuhito Watanabe, Akira Sugihara, Narihiko Kondo, Takeshi Nishiyasu
    • Organizer
      14th International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio, Greece
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans2011

    • Author(s)
      Kazuhito Watanabe, Masashi Ichinose, Stephane Delliaux, Naoto Fujii, Takeshi Nishiyasu
    • Organizer
      14th International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio, Greece
    • Year and Date
      2011-07-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hypervolemia from fluid ingestion at rest : effects of sodium and glucose2011

    • Author(s)
      Akira Sugihara, Naoto Fujii, Bun Tsuji, Kazuhito Watanabe, Takehiro Niwa, Takeshi Nishiyasu
    • Organizer
      14th International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio, Greece
    • Year and Date
      2011-07-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans2011

    • Author(s)
      Kazuhito Watanabe, Masashi Ichinose, Stephane Delliaux, Naoto Fujii, Takeshi Nishiyasu
    • Organizer
      Biotechnology and Biological Sciences Research Council-Japanese Partnership Symposium
    • Place of Presentation
      Leeds, United Kingdom
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of pre-exercise ingestion of sodium and glucose on physiological responses and performance during exercise in the heat2011

    • Author(s)
      Akira Sugihara, Naoto Fujii, Bun Tsuji, Kazuhito Watanabe, Takehiro Niwa, Takeshi Nishiyasu
    • Organizer
      Biotechnology and Biological Sciences Research Council-Japanese Partnership Symposium
    • Place of Presentation
      Leeds, United Kingdom
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] The influence of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans2011

    • Author(s)
      Naoto Fujii, Yasushi Honda, Stephane Delliaux, Bun Tsuji, Kazuhito Watanabe, Akira Sugihara, Narihiko Kondo, Takeshi Nishiyasu
    • Organizer
      Biotechnology and Biological Sciences Research Council-Japanese Partnership Symposium
    • Place of Presentation
      Leeds, United Kingdom
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during activation of the muscle metaboreflex in the forearm and calf in humans2011

    • Author(s)
      Kazuhito Watanabe, Masashi Ichinose, Naoto Fujii, Bun Tsuji, Akira Sugihara, Takehiro Niwa, Takeshi Nishiyasu
    • Organizer
      16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Arena and convention centre (Liverpool, UK)
    • Year and Date
      2011-07-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of pre-exercise ingestion of sodium and glucose on physiological responses and performance during exercise in the heat2011

    • Author(s)
      Akira Sugihara, Naoto Fujii, Bun Tsuji, Kazuhito Watanabe, Takehiro Niwa, Takeshi Nishiyasu
    • Organizer
      16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Arena and convention centre (Liverpool, UK)
    • Year and Date
      2011-07-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Arterial blood pressure response to severe passive heating at rest relates to hyperthermia-induced hyperventilation in humans2011

    • Author(s)
      Naoto Fujii, Masashi Ichinose, Yasushi Honda, Bun Tsuji, Kazuhito Watanabe, Narihiko Kondo, Takeshi Nishiyasu
    • Organizer
      16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Arena and convention centre (Liverpool, UK)
    • Year and Date
      2011-07-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Muscle metaboreflex modulates dynamic cardiovascular responses to acute hypotension in humans2011

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu
    • Organizer
      The 58th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      Denver, Colorado
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report

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Published: 2011-12-12   Modified: 2024-03-26  

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