Project/Area Number |
11J00743
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Research Category |
Grant-in-Aid for JSPS Fellows
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Allocation Type | Single-year Grants |
Section | 国内 |
Research Field |
Public health/Health science
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Research Institution | University of Tsukuba |
Principal Investigator |
菅原 歩美 筑波大学, 医学医療系, 特別研究員(PD)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2013: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2012: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2011: ¥600,000 (Direct Cost: ¥600,000)
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Keywords | 生活習慣 / 糖尿病発症 / 血糖変動 / 糖尿病性腎症 / やせ / ダイエット / 母子関係 |
Research Abstract |
やせや肥満の背景には、食事や運動だけでなく、喫煙や飲酒・睡眠などの生活習慣が関連している。多くの研究では、対象者の飲酒量と喫煙量には相関関係が見られるが、適量飲酒者の喫煙が糖尿病発症に及ぼす影響は明らかでない。そこで本研究では茨城県民の住民健診の縦断的データを使用し、飲酒・喫煙を層別化して組み合わせた際の糖尿病発症リスクを検討することを目的とした。結果は日本疫学会、日本糖尿病学会において発表された。【方法】対象者は、1993年に茨城県検診を受診した40-79歳の男性63865名とし、糖尿病罹患者(空腹時血糖値≧7.0mo1/1または随時血糖値≧11.1mol/lまたは糖尿病治療中)(n=3116)、データ欠損者(n=346)、継続受診しなかった者(n=16809)、喫煙または飲酒をやめた者(n=20671)を除外した22923名を2007年まで追跡した。喫煙は「なし、タバコ20本/日未満、20本/日以上」、飲酒は「なし、アルコール摂取量15g/日未満、15g-30g日、30g/日以上」に分類し、両者の組み合わせによる糖尿病発症リスクを検討した。リスク比はCox比例ハザードモデルを使って計算した。解析にはSAS9.3を使用した。【結果】非喫煙かつ非飲酒群と比較して、一日にタバコ20本以上の喫煙かつアルコール摂取量30g以上の群では糖尿病発症のハザード比は1.42(95%信頼区間 : 1.21-1.67)となった。また、非喫煙群では、J字型の傾向を示した。一方喫煙群では、タバコ20本/日未満の群では、それぞれ1.26(0.94-1.69), 1.27(1.04-1.54), 1.38(113-1.68)、20本/日以上の群では飲酒量が増えるにつれて直線的に糖尿病発症のハザード比が上昇した。【総括】喫煙と飲酒が重なることで、どちらかのみを摂取している場合よりもさらに糖尿病発症リスクが上昇した。また、適量飲酒による糖尿病発症リスク低下の効果は、喫煙によって打ち消される可能性が示唆される。
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Strategy for Future Research Activity |
(抄録なし)
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome : A Meta-Analysis.2013
Author(s)
Fujihara K, Kodama S, Horikawa C, Yoshizawa S, Sugawara A, Hirasawa R, Shimano H, Yachi Y, Suzuki A, Hanyu O, Sone H
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Journal Title
Sleep Disord
Volume: 2013
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Quality and accuracy of Internet information concerning a healthy diet2013
Author(s)
Hirasawa R, Yachi Y, Yoshizawa S, Horikawa C, Heianza Y, Sugawara A, Sone Y, Kondo K, Shimano H, Saito K, Kodama S, Sone H.
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Journal Title
Int J Food Sci Nutr
Volume: 64
Issue: 8
Pages: 1007-1013
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis2012
Author(s)
Kodama S, Horikawa C, Fujihara K, Heianza Y; Hirasawa R, Yachi, Sugawara A, Tanaka S, Shimano H, Iida KT, Saito K, Sone H.
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Journal Title
Am J Epidemiol.
Volume: 176
Pages: 959-69
Related Report
Peer Reviewed
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[Journal Article] Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan2011
Author(s)
Sugawara A, Sato M, Totsuka K, Saito K, Kodama S, Fukushi A, Yamanashi Y, Matsushima E, Fujiwara Y, Suzuk E, Kondo K, Yamamoto Y, Sone H
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Journal Title
Eating and Weight Disorders
Volume: 16
Related Report
Peer Reviewed
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[Presentation] Predictive ability of simple clinical information without blood tests for future incident diabetes : a meta-analysis.2013
Author(s)
Yoshizawa S, Kodama S, Fulihara K, Horikawa C, Sugawara A, Heianza Y, Yachi Y, Tanaka S, Minagawa S, Yamada T, Suzuki A, Hanyu O, Kodama S, Shimano H, Sone H
Organizer
49th European Association for the Study of Diabetes
Place of Presentation
The Fira de Barcelona's Gran Via exhibition centre Barcelona Barcelona, Spain
Year and Date
2013-09-24
Related Report
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[Presentation] Trajectory of body mass index before the development of type 2 diabetes in Japanese men : Toranomon hospital health management center study (TOPICS)2013
Author(s)
Heianza Y, Arase Y, Hara S, Fujihara K, Hsieh S, Sugawara A, Suzuki A, Hanyu O, Saito K, Kaadama S, Sjhimano H. Sone H
Organizer
49th European Association for the Study of Diabetes
Place of Presentation
The Fira de Barcelona's Gran Via exhibition centre Barcelona, Spain
Year and Date
2013-09-24
Related Report
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[Presentation] Relationship of Living Alone with Undiagnosed Diabetes in Japan : Toranomon Hospital Health Management Center Study. 73rd American Diabetes Association Scientific Sessions.2013
Author(s)
Heianza Y, Arase Y, Kodama S, Hsieh SD, Sugawara A, Tanaka S, Suzuki A, Hanyu O, Saito K, Shimano H, Hara S, Sone H.
Organizer
73rd American Diabetes Association Scientific Sessions.
Place of Presentation
McCormick Place Convention Center, Chicago, USA
Year and Date
2013-06-22
Related Report
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[Presentation] Combined Risk of Alcohol Intake and Smoking for Development of Type 2 Diabetes in the General Population in Japan : the Ibaraki Prefectural Health Study. 73rd American Diabetes Association Scientific Sessions.2013
Author(s)
Sugawara A, Sairenchi T, Fujihara K, Irie F, Watanabe H, Suzuki H, Shimano H, Hanyu O, Sone H, Ota H, Ibaraki Health Plaza.
Organizer
73rd American Diabetes Association Scientific Sessions.
Place of Presentation
McCormick Place Convention Center, Chicago. USA
Year and Date
2013-06-22
Related Report
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[Presentation] Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome-A Meta-Analysis.2013
Author(s)
Eujihara K, Kodama S, Horikawa C, Sugawara A, Heianza Y, Yachi Y, Saito K, Shimano H, Hanyu O, Sone H.
Organizer
73rd American Diabetes Association Scientific Sessions.
Place of Presentation
McCormick Place Convention Center, Chicago. USA
Year and Date
2013-06-22
Related Report
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[Presentation] Determining Optimal Combined Thresholds of HbAlc and Fasting Plasma Glucose as Predictors of Type 2 Diabetes: The Toranomon Hospital Health Management Center Study2012
Author(s)
Sugawara A, Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Yamada N, Hara S, Sone H,
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-10
Related Report
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[Presentation] Study group. Differences in Relationships between Diabetes Duration and Diabetes-Related Psychological Distress : Japan Diabetes Clinical Data Management Study2012
Author(s)
Sugawara A, Kawai K, Yuhara A, Oishi M, Sugimoto H, Yokoyama H, Yagi N, Okada A, Iwasaki K, Miyazawa K, Okuguchi F, Dake F, Saito A, Saito K, Sone H, Japan Diabetes Clinical Data Manegement
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-10
Related Report
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[Presentation] Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study2012
Author(s)
Heianza Y, Arase Y; Tsuji H, Sugawara A, Saito K, Hsieh SD, Amakawa K, Kodama S, Yamada N, Hara S, Sone H.
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-10
Related Report
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[Presentation] Quality and Accuracy of Internet Information Concerning a Healthy Diet2012
Author(s)
Hirasawa R, Sugawara A, Saito K, Kodama S, Yachi Y, Yoshizawa S, Horikawa R, Heianza Y, lbe Y, Sone H.
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-10
Related Report
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[Presentation] A Meta-Analysis of the Quantitative Relationship Between Fat Intake and Incident DM2012
Author(s)
Tajima R, Kodama S, Horikawa C, Yachi Y; Sueawara A, Heianza Y, Hirasawa R, Fujihara K, Saito K, Iida TK, Sone H.
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-10
Related Report
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[Presentation] 成人における糖尿病と難聴の関連性:メタアナリシスにおける評価2012
Author(s)
堀川千嘉, 児玉暁, 菅原歩美, 平安座依子, 由澤咲子, 齋藤あき, 伊部陽子, 平澤玲子, 谷内洋子, 齋藤和美, 曽根博仁
Organizer
第22回日本疫学会学術総会
Place of Presentation
東京
Year and Date
2012-01-26
Related Report
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[Presentation] 2型糖尿病発症予測に最適なHbAlcと空腹時血糖値の閾値の組み合わせの検討:TOPICS2012
Author(s)
平安座依子, 原茂子, 謝勲東, 齋藤和美, 辻裕之, 菅原歩美, 齋藤あき, 児玉暁, 荒瀬康司, 山田信博, 曽根博仁
Organizer
第46回日本成人病学会学術集会
Place of Presentation
東京
Year and Date
2012-01-15
Related Report
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[Presentation] 2型糖尿病における知識と負担感との関連の検討2012
Author(s)
菅原歩美, 湯原淳良、 大石まり子, 杉本英克, 横山宏樹, 屋宜宣治, 岡田朗, 岩崎皓一, 宮澤一裕, 奥口文宣, 嵩文彦, 齋藤あき, 西垣結佳子, 川井紘一, 曽根博仁
Organizer
第46回日本成人病学会学術集会
Place of Presentation
東京
Year and Date
2012-01-14
Related Report
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[Presentation] "Healthy diet"に関する国際的ウェブ情報のクオリティの検証2012
Author(s)
平澤玲子, 谷内洋子, 伊部陽子, 由澤咲子, 堀川千嘉, 齋藤あき, 平安座依子, 菅原歩美, 戸塚久美子, 齋藤和美, 児玉暁, 曽根博仁
Organizer
第46回日本成人病学会学術集会
Place of Presentation
東京
Year and Date
2012-01-14
Related Report
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[Presentation] Potential impact of elevated HbAlc and impared fasting glucose on population for predicting risk of diabetes : The Toranomon Hospital Health Management Center Study2011
Author(s)
Heianza Y, Hara S, Horikawa C, Saito K, Sugawara A, Fujiwara K, Kodama S, Hsieh SD, Tsuji H, Shimano H, Yamada N, Arase Y, Sone H
Organizer
47th EASD Annual Meeting
Place of Presentation
Lisbon, Portugal
Year and Date
2011-09-13
Related Report
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[Presentation] Screening using various cutoffs of HbAlc and impaired fasting plasma glucose for predicting future diabetes : The Toranomon hospital health management center study2011
Author(s)
Horikawa C, Heianza Y, Hara S, Arase Y, Saito K, Fujiwara K, Sugawara A, Tsuji H, Kodama S, Hsieh SD, Shimano H, Yamada N, Sone H
Organizer
47th EASD Annual Meeting
Place of Presentation
Lisbon, Portugal
Year and Date
2011-09-13
Related Report
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[Presentation] Low BMI at age 20 years predicts gestational diabetes independent of BMI in early pregnancy : Tanaka Women's Clinic Study2011
Author(s)
Yachi Y, Horikawa C, Heianza Y, Sugawara A, Saito A, Fujiwara K, Nishibata I, Yasuhara M, Kobayashi K, Kodama S, Saito K, Tanaka Y, Sone H
Organizer
47th EASD Annual Meeting
Place of Presentation
Lisbon, Portugal
Year and Date
2011-09-13
Related Report
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[Presentation] HbAlc variability and risk of development of microalbuminuria in Japanese patients with type 2 diabetes : a pilot study, Tsukuba Kawai Diabetes Registry32011
Author(s)
Sugawara A, Kawai K, Motohashi S, Fujiwara K, Hirasawa R, Igawa K, Kobayashi K, Saito K, Yamazaki K, Sone H
Organizer
71th American Diabetes Association Scientific Sessions
Place of Presentation
San Diego, USA
Year and Date
2011-06-25
Related Report
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[Presentation] Diabetes and Risk of Hearing Impairment : A Meta-analysis2011
Author(s)
Horikawa C, Kodama S, Heianza Y, Saito A, Hirasawa R, Sugawara, A, Totsuka K, Maki M, Saito K, Sone H
Organizer
71th American Diabetes Association Scientific Sessions
Place of Presentation
San Diego, USA
Year and Date
2011-06-25
Related Report
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[Presentation] Is the waist-to-statue ratio a better predictor than other anthropometric in dicators to predict future diabetes risk? A meta-analysis2011
Author(s)
Kodama S, Horikawa C, Heianza Y, Sugawara A, Ibe Y, Yachi Y, Maki M, Shu M, Saito K, Sone H
Organizer
71th American Diabetes Association Scientific Sessions
Place of Presentation
San Diego, USA
Year and Date
2011-06-25
Related Report
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[Presentation] 経口ブドウ糖負荷前・負荷後血糖の心血管疾患リスクの量的関係の解析(メタアナリシス)2011
Author(s)
齋藤和美, 児玉暁, 堀川千嘉, 伊部陽子, 平澤玲子, 谷内洋子, 菅原歩美, 小林和人, 高橋昭光, 島野仁, 山田信博, 曽根博仁
Organizer
第54回日本糖尿病学会年次学術集会
Place of Presentation
札幌
Year and Date
2011-05-20
Related Report
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[Presentation] 2型糖尿病患者における、糖・脂質摂取比(C/F比)が糖・脂質代謝に及ぼす影響のメタアナリシス2011
Author(s)
萱原歩美, 児玉暁, 牧美保, 堀川千嘉、藤原和哉, 平安座依子, 齋藤あき, 西垣結佳子, 伊部陽子, 平澤玲子, 谷内洋子, 齋藤和美, 曽根博仁
Organizer
第65回日本栄養・食糧学会大会
Place of Presentation
東京
Year and Date
2011-05-15
Related Report
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[Presentation] 食生活に関する国際的ウェブ情報のクオリティの検証-Mediterranean dietを例に-2011
Author(s)
平澤玲子, 谷内洋子, 堀川千嘉, 平安座依子, 齋藤あき, 藤原和哉, 菅原歩美, 齋藤和美, 飯田薫子, 藤原葉子, 近藤和雄, 曽根博仁
Organizer
第65回日本栄養・食糧学会大会
Place of Presentation
東京
Year and Date
2011-05-14
Related Report
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[Presentation] 二十歳時から妊娠時までのBMI変化と妊娠糖尿病発症リスクとの関連(TWC Study)2011
Author(s)
谷内洋子, 田中康弘, 穴迫唯衣, 菅原歩美, 戸塚久美子, 赤松利恵, 近藤和雄, 鈴木恵美子, 飯田薫子, 児玉暁, 齋藤和美, 曽根博仁
Organizer
第65回日本栄養・食糧学会大会
Place of Presentation
東京
Year and Date
2011-05-14
Related Report
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