• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

内分泌攪乱物質の環境リスク

Research Project

Project/Area Number 12055101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

松井 三郎  京都大学, 地球環境学堂, 教授 (90092808)

Co-Investigator(Kenkyū-buntansha) 森 千里  千葉大学, 医学研究科, 教授 (90174375)
田辺 信介  愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
井口 泰泉  自然科学研究機構, 統合バイオサイエンスセンター, 教授 (90128588)
吉原 新一  広島国際大学, 薬学部, 教授 (00037607)
有薗 幸司  熊本県立大学, 環境共生学部, 教授 (70128148)
森澤 眞輔  京都大学, 工学研究科, 教授 (50026340)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥115,700,000 (Direct Cost: ¥115,700,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2002: ¥37,600,000 (Direct Cost: ¥37,600,000)
Fiscal Year 2001: ¥61,000,000 (Direct Cost: ¥61,000,000)
Keywords内分泌撹乱物質 / 環境リスク / 国際シンポジウム / 毒性メカニズム / 人体汚染 / 野生生物汚染 / 代謝機構 / バイオアッセイ・バイオマーカー / 人体影響 / バイオアッセイ / DNAマイクロアレイ
Research Abstract

特定領域研究「内分泌撹乱物質の環境リスク」(平成12年度〜16年度)の研究成果の発表と今後の展望について議論するため、平成17年1月22、23日に京都大学時計台記念館国際交流ホールII、IIIにおいて、国際シンポジウムを開催した。タイトルは"International Symposium, The Environmental Risk of Endocrine Disrupter - Fruits of Research and Future Perspectives- "である。主に総括班のメンバーが講演を行った。セッションは(1)人体への曝露、影響、毒性メカニズム、(2)地球規模または地域の環境汚染、(3)バイオアッセイ、バイオマーカー、(4)リスク評価、(5)総合討論、という構成で行った。また、ゲストスピーカーとして、黒田洋一郎先生(水酸化PCBによる脳神経影響について)、関澤純先生(リスクコミニュケーション)、エリザベス ジレット先生(農薬の脳神経影響の疫学調査)、アーマド イスマイル先生(マレーシアにおける有機スズ化合物の汚染状況)、クルンザカラム カンナン先生(Perfluorinated Acidsの地球規模汚染)、ポール ラム先生(バイオマーカーを利用した環境汚染モニタリング)らを招き、活発な討議を行った。講演18題、ポスター発表31題の発表があった。最後に領域代表者が司会してシンポジウムの総括を行った。

Report

(5 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (27 results)

All 2005 2004 Other

All Journal Article (6 results) Publications (21 results)

  • [Journal Article] Necessity to measure PCBs and organochlorine pesticide concentrations in human umbilical cords for fetal exposure : assessment.2005

    • Author(s)
      Fukata H, Omori M, Osada H, Todaka E, Mori C
    • Journal Title

      Environ Health Perspect (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mercury contamination in human hair and fish from Cambodia : levels, specific accumulation and risk assessment.2005

    • Author(s)
      Agusa, T., Tanabe, S.et al.
    • Journal Title

      Environmental Pollution 134(1)

      Pages: 79-86

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tissue-specific estrogenic and non-estrogenic effects of a xenoestrogen, nonylphenol.2005

    • Author(s)
      Watanabe, H., A.Suzuki, M.Goto, D.B.Lubahn, H.Handa, T.Iguchi
    • Journal Title

      J.Mol.Endocr. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comparative Study of the Endocrine-disrupting Activity of Bisphenol A and 19 Related Compounds.2005

    • Author(s)
      S.Kitamura, S.Yoshihara, et al.
    • Journal Title

      Toxicological Sciences (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comparison of Gene Expression Patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a Natural Arylhydrocarbon Receptor Ligand Indirubin2004

    • Author(s)
      J.Adachi, Y.Mori, S.Matsui, T.Matsuda
    • Journal Title

      Toxicol.Sci 80

      Pages: 161-169

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 化学物質による健康リスクの予見的評価2004

    • Author(s)
      森澤眞輔
    • Journal Title

      科学と工業 78

      Pages: 400-405

    • Related Report
      2004 Annual Research Report
  • [Publications] Y.Shimizu, S.Matsui et al.: "Evaluation of microorganic pollution in lake sediments : Application to Akanoi Bay"Environ Technol. 24(7). 889-896 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Yasui, S.Matsui, T.Matsuda et al.: "Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells"Carcinogenesis. 24(5). 911-917 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mori C, Komiyama M, Adachi T et al.: "Application of toxicogenomic analysis to risk assessment of delayed long-term effects of multiple chemicals including endocrine disruptors in human fetuses."Environ Health Persp. 111. 803-809 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kubota, R., Kunito, T., Tanabe, S.: "Occurrence of several arsenic compounds in the liver of birds, cetaceans, pinnipeds, and sea turtles."Environmental Toxicology and Chemistry. 22(6). 1200-1207 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato, H., T.Ota, T.Furuhashi, Y.Ohta, T.Iguchi: "Changes in reproductive organs of female rats treated with bisphenol A-during the neonatal period."Reprod.Toxicol.. 17. 283-288 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Ishibashi, K.Arizono, et al.: "Monitoring of environmental pollutants by a combination of biomarkers in minamata river water using goldfish(Carassius auratus)"Environmental Sciences. 10(3). 175-186 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Matsui, B.C.Lee, F.Kawami, Y.Shimizu, T.Matsuda: "High-performance liquid chromatography-bioassay profiles of endocrine disrupters discharged from point and non-point pollution sources in Lake Biwa basin"Lakes & Reservoirs : Research and Management. 7. 289-293 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Shimizu, J.Takahashi, J.Matubara, K.Ikeda, S.Matsui: "Sorption of polycyclic aromatic hydrocarbons into liposomes (artifical cell membranes) and the effects of dissolved natural organic matter"Lakes & Reservoirs : Research and Management. 7. 295-300 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松田知成, 松井三郎: "ヒト尿中に存在する強力なAhRリガンド、インディルビン"医学のあゆみ. 201. 157-158 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Yasui, S.Matsui, Y.R.S Laxmi, N.Suzuki, S.Kim, S.Shibutani, T.Matsuda: "Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells"Carcinogenesis. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] I.Watanabe, T.Kunito, S.Tanabe, M.Amano, Y.Koyama, N.Miyazaki, E.A.Petov, R.Tatsukawa: "Accumulation of Heavy Metals in Caspian Seals (Phoca caspica)"Arch. Environ. Contam. Toxicol. 43. 109-120 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松井三郎, 田辺信介, 森千里, 井口泰泉, 吉原新一, 有薗幸司, 森澤眞輔: "環境ホルモンの最前線"有斐閣. 252 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 井口泰泉 監修: "環境ホルモンの最新動向と測定・試験・機器開発"シーエムシー出版. 330 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Adachi, Y.Mori, S.Matsui, T.Matsuda, et al.: "Indirubin and indigo are potent Aryl hydrocarbon receptor ligands present in human urine"J. Biol. Chem. 276(34). 31475-31478 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Watanabe, D.L.Buchanan, H.Handa, T.Iguchi: "Global analysis of gene expression induced by environmental endocrine disruptors"Perspective in Comparative Endocrinology. 147-151 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ichiro Takeuchi et al.: "Caprella watch : a new approach for monitoring butyltin residues in the ocean"Marine Environmental Research. 52(2). 97-113 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Mori: "Possible effects of endocrine disruptors on male reproductive function"Acta Anatomica Nipponica. 76. 361-368 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Yoshiwara: "Metabolic Activation of Bisphenol A by Rat Liver 89 Fraction"Toxicological Sciences. 62. 221-227 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Morisawa et al.: "The Dynamic Performances of DDTs in the Environment and Their Exposure to Japanese : A Historical Perspective after the Ban"Journal of Risk Analysis. 22(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 井口泰泉: "奪われし未来、増補改訂版"翔泳社. 32 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 田辺信介: "有機塩素化合物のグローバルな動態,内分泌攪乱物質研究の最前線 季刊化学総説No.50"学会出版センター. 73-78 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi