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Dynamics of Developmental Systems

Research Project

Project/Area Number 12061101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute for Basic Biology (2004-2006)
Okazaki National Research Institutes (2000-2003)

Principal Investigator

UENO Naoto  基礎生物学研究所, 形態形成研究部門, 教授 (40221105)

Co-Investigator(Kenkyū-buntansha) 八杉 貞夫  東京都立大学, 大学院・理学研究科, 教授 (70011591)
野地 澄晴  徳島大学, 工学部, 教授 (40156211)
井出 宏之 (井出 浩之)  東北大学, 大学院・理学研究科, 教授 (70022704)
西川 伸一  京都大学, 大学院・理学研究科, 教授 (60127115)
勝木 元也  岡崎国立共同研究機構, 基礎生物学研究所, 所長 (20051732)
小林 悟  筑波大学, 生物科学系, 講師 (90225508)
西田 宏記  東京工業大学, 生命理工学部, 助教授 (60192689)
平良 眞規  東京大学, 大学院・理学研究科, 助教授 (60150083)
田代 康介  九州大学, 大学院・生物資源環境科, 助教授 (00192170)
Project Period (FY) 2004 – 2008
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥52,400,000 (Direct Cost: ¥52,400,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2004: ¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 2003: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2002: ¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 2001: ¥12,200,000 (Direct Cost: ¥12,200,000)
Keywordsearly development / embryonic induction / cell-to-cell interation / microarray / organogenesis / evolution / morphology / gene network / 胚誘導 / 器官形成 / 進化 / 形態 / 遺伝子ネットワーク / 再生 / 形態形成 / シグナル伝達 / 幹細胞 / 組織再生 / 生物多様性 / 遺伝子プログラム
Research Abstract

「発生システムのダイナミクス」における班員の、体軸の決定、胚葉の組織パターン形成、器官形成などの諸現象に関わる分子レベルでの詳細な研究から、発生システムを構築する遺伝子群は発生過程あるいは再生過程においても繰り返し用いられていることが実証されてきた。また、さまざまな動植物種を用いた比較発生学研究によって、「発生システム」は種をも超えて保存されていることも明らかにされ、システム自身が生物の進化とともに永続的に変化、適応してきたことを強く示唆することができた。すなわち、本特定領域研究によって「発生システム」の進化そのものが生物の多様性獲得の原動力となっていることを示すことができたと考えている。本特定領域研究では遺伝子群自身の存在はすでに明らかにされたものとし、時系列における発生制御遺伝子の活性化パターンの解析から、異なる遺伝子カスケード間のクロストーク、フィードバック制御など、発生現象を制御する複雑なシステムをより大局的にとらえ未知の発生原理に迫ることを試みた。また、それぞれのレベルで質の高い研究を生み出すことができた。本特定領域研究の終了にあたり、比較的若手の班員のなかからとくに優れた研究成果を挙げたものを選び、約50人の参加者による合宿形式で、成果発表、討論を行うことにより、初期発生、再生、器官形成、進化の観点から21世紀の生物学に残された課題は何か討論するとともに、将来の発生生物学を展望するための会議を行った。
会議は若手班員が成果発表し、シニア研究者が議論を誘導するという形式で行われた。合宿形式ということもあって、会議終了後、参加者の一部では、夜中まで討論が続くという極めて有意義な集まりとなった。

Report

(8 results)
  • 2006 Annual Research Report
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (67 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (38 results) Publications (29 results)

  • [Journal Article] Monounsaturated fatty acid modification of Wnt protein : its role in Wnt secretion.2006

    • Author(s)
      Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., Takada, S.
    • Journal Title

      Dev. Cell 11

      Pages: 791-801

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleosome regulator Xhmgb3 is required for cell proliferation of the eye and brain as a downstream target of Xenopus rax/Rx1.2006

    • Author(s)
      Terada, K., Kitayama, A., Kanamoto, T., Ueno, N., Furukawa, T.
    • Journal Title

      Dev. Cell 291

      Pages: 398-412

    • Related Report
      2006 Annual Research Report
  • [Journal Article] XGAP, and ArfGAP, is required for polarized localizaton of PAR proteins and cell polarity in Xenopus gastrulation.2006

    • Author(s)
      Hyodo-Miura, J., Yamamoto, TS., Hyodo, AC., Iemusa, S., Kusakabe, M, Nishida, E., Natsume T., Ueno, N.
    • Journal Title

      Dev. Cell 11

      Pages: 69-79

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transgenic Xenopus laevis strain expressing cre recombinase in muscle cells.2006

    • Author(s)
      Waldner C., Sakamaki, K., Ueno N., Turan, G., Ryffel GU.
    • Journal Title

      Dev. Dyn. 235

      Pages: 2220-2228

    • Related Report
      2006 Annual Research Report
  • [Journal Article] FGF signal regulates gastrulation cell movements and morphology through its target NRH.2005

    • Author(s)
      Chung, H.A., Hyodo-Miura, J., Nagamune, T., Ueno, N.
    • Journal Title

      Dev. Biol. 282

      Pages: 95-110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development.2005

    • Author(s)
      Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., Yasugi, S.
    • Journal Title

      Development 132

      Pages: 2783-2793

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] caudal is required for gnathal and thoracic patterning and for posterior elongation in the intermediate-germband cricket Gryllus bimaculatus.2005

    • Author(s)
      Shinmyo, Y., Mito, T., Matsushita, T., Sarashina, I., Miyawaki, K., Ohuchi, H., Noji, S.
    • Journal Title

      Mech. Dev. 122

      Pages: 231-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Non-canonical functions of hunchback in segment patterning of the intermediate germ cricket Gryllus bimaculatus.2005

    • Author(s)
      Mito T, Sarashina I, Zhang H, Iwahashi A, Okamoto H, Miyawaki K, Shinmyo Y, Ohuchi H, Noji, S.
    • Journal Title

      Development 132

      Pages: 2069-2079

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development.2005

    • Author(s)
      Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., *Yasugi, S.
    • Journal Title

      Development 132

      Pages: 2783-2793

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] caudal is required for gnathalandthoracicpatterning and for posterior elongation in the intermediate-germband cricket Gryllus bimaculatus.2005

    • Author(s)
      Shinmyo, Y., Mito, T., Matsushita, T., Sarashina, I., Miyawaki, K., Ohuchi, H., *Noji, S.
    • Journal Title

      Mech. Dev. 122

      Pages: 231-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Non-canonical functions of hunchback in segment patterning of the intermediate germ cricket Gryllus bimaculatus.2005

    • Author(s)
      Mito T, Sarashina I, Zhang H, Iwahashi A, Okamoto H, Miyawaki K, Shinmyo Y, Ohuchi H, *Noji, S.
    • Journal Title

      Development 132

      Pages: 2069-2079

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] FGF signal regulates gastrulation cell movements and morphology through its target NRH2005

    • Author(s)
      Chung, H.A.et al.
    • Journal Title

      Dev.Biol. 282

      Pages: 95-110

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of asymmetrically localized transcripts along the animal-vegetal axis of the Xenopus egg.2005

    • Author(s)
      Kataoka, K.et al.
    • Journal Title

      Dev Growth Differ. 47

      Pages: 511-521

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transgenic frogs expressing the highly fluorescent protein venus under the control of a strong mammalian promoter suitable for monitoring living cells.2005

    • Author(s)
      Sakamaki, K.
    • Journal Title

      Dev Dyn.et al. 233

      Pages: 562-569

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of MADS-box genes in charophycean green alga and its implication for the evolution of MADS-box genes2005

    • Author(s)
      Tanabe*, Y. et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 102(7)

      Pages: 2436-2441

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Screening of FGF target genes in Xenopus by microarray : temporal dissection of the signalling pathway using a chemical inhibitor.2004

    • Author(s)
      Chung, H.A., Hyodo-Miura, J., Kitayama, A., Terasaka, C., Nagamune, T., Ueno, N.
    • Journal Title

      Genes Cells 9

      Pages: 749-761

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo2004

    • Author(s)
      Hiramatsu, H., Yasugi, S.
    • Journal Title

      Int. J. Dev. Biol. 48

      Pages: 1141-1148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Screening of FGF target genes in Xenopus by microarray : temporal dissection of the signalling pathway using a chemical inhibitor.2004

    • Author(s)
      Chung, H.A., Hyodo-Miura, J., Kitayama, A., Terasaka, C., Nagamune, T., *Ueno, N.
    • Journal Title

      Genes Cells 9

      Pages: 749-761

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo.2004

    • Author(s)
      Hiramatsu, H., *Yasugi, S.
    • Journal Title

      Int. J. Dev. Biol. 48

      Pages: 1141-1148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nanos suppresses somatic cell fate in Drosophila germline2004

    • Author(s)
      Hayashi, Y. et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 10338-10342

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum2004

    • Author(s)
      Matsumoto, Ken et al.
    • Journal Title

      Nature Neuroscience 7

      Pages: 605-612

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Morphpgens, their identification and regulation.2004

    • Author(s)
      Tabata, T. et al.
    • Journal Title

      Development 131(4)

      Pages: 703-712

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Lamprey Hox genes and the evolution of jaws.2004

    • Author(s)
      Takio, Y. et al.
    • Journal Title

      Nature 429

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.2003

    • Author(s)
      Ohkawara, B., Yamamoto, T., Tada, M., Ueno, N.
    • Journal Title

      Development 130

      Pages: 2129-2138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.2003

    • Author(s)
      Ohkawara, B., Yamamoto, T., Tada, M., *Ueno, N.
    • Journal Title

      Development 130

      Pages: 2129-2138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo2003

    • Author(s)
      Yamamoto, M. et al.
    • Journal Title

      Nature 428

      Pages: 387-392

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Action range of BMP is defined by its N-terminal basic amino acid core.2002

    • Author(s)
      Ohkawara, B., Iemura, S.-I., ten Dijke, P., Ueno, N.
    • Journal Title

      Curr. Biol. 12

      Pages: 1-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A C. elegans TGF-β, DBL-1, controls the expression of LON-1 that regulates polyploidization and body length.2002

    • Author(s)
      Morita, K., Flemming, A., Sugihara, Y., Mochii, M., Suzuki, Y., Yoshida, S., Wood, B., Kohara, Y., Leroi, A.M., Ueno N.
    • Journal Title

      EMBO J. 21

      Pages: 1063-1073

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach.2002

    • Author(s)
      Takeda, J., Tabata, H., Fukuda, K., Yasugi, S.
    • Journal Title

      Dev. Growth & Differ 44

      Pages: 501-508

    • NAID

      10010211924

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development.2002

    • Author(s)
      Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., Yasugi, S.
    • Journal Title

      Dev. Dyn. 223

      Pages: 33-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correlation of expression patterns of homothorax, dachshund, and Distal-less with the proximodistal segmentation of cricket leg bud.2002

    • Author(s)
      Inoue, Y., Mito, T., Miyawaki, K., Matsushima, K., Shinmyo, Y., Heanue, T.A., Mardon, G., Ohuchi, H., Noji, S.
    • Journal Title

      Mech. Dev. 113

      Pages: 141-148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model.2002

    • Author(s)
      Mito, T., Inoue, Y., Kimura, S., Miyawaki, K., Niwa, N., Shinmyo, Y., Ohuchi, H., Noji, S.
    • Journal Title

      Mech. Dev. 114

      Pages: 27-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Action range of BMP is defined by its N-terminal basic amino acid core.2002

    • Author(s)
      Ohkawara, B., Iemura, S.-L, ten Dijke, P., *Ueno.N.
    • Journal Title

      Curr. Biol. 12

      Pages: 1-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] elegans TGF-b, DBL-1, controls the expression of LON-1 that regulates polyploidization and body length.2002

    • Author(s)
      Morita, K., Flemming, A., Sugihara, Y., Mochii, M., Suzuki, Y.Yoshida, S., Wood, B., Kohara, Y., Leroi, A.M., *Ueno N.A C.
    • Journal Title

      EMBO J. 21

      Pages: 1063-1073

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach.2002

    • Author(s)
      Takeda, J., Tabata, H., Fukuda, K., *Yasugi, S.
    • Journal Title

      Dev. Growth & Differ. 44

    • NAID

      10010211924

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development.2002

    • Author(s)
      Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., *Yasugi, S.
    • Journal Title

      Dev. Dyn. 223

      Pages: 33-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correlation of expression patterns of homothorax, dachshund, and Distal-less with the proximodistal segmentation of cricket leg bud. Mech. Dev.113, 141-148, 20022002

    • Author(s)
      Inoue, Y., Mito, T., Miyawaki, K., Matsushima, K., Shinmyo, Y., Heanue, T.A., Mardon, G., Ohuchi, H., *Noji, S.
    • Journal Title

      Mech. Dev. 113

      Pages: 141-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model.2002

    • Author(s)
      Mito, T., Inoue, Y., Kimura, S., Miyawaki, K., Niwa, N., Shinmyo, Y., Ohuchi, H., *Noji, S.
    • Journal Title

      Mech. Dev. 114

      Pages: 27-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Tsuda, M.: "Conserved role of nanos proteins in germ cell development."Science. 301. 1239-1241 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mitsui, K. et al.: "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."Cell. 113. 631-642 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi, K.: "Role of ERas in promoting tumour-like properties in mouse embryonic stem cells."Nature. 423. 541-545 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kinoshita, N.: "PKCd is essential for Dishevelled function in a non-canonical Wnt pathway that regulates Xenopus convergent extension movements."Genes Dev.. 17. 1663-1676 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Agata, K.: "Regeneration and gene regulation of planarians."Curr.Opinion Genet.Dev.. 13. 492-496 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sardet, C. et al.: "Maternal mRNAs of PEM and macho 1, the ascidian muscle determinant, associate and move with a rough endoplasmic reticulum network in the egg cortex"Development. 130. 5389-5349 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morita, K., Flemming, A., Sugihara, Y., Mochii, M., Suzuki, Y., Yoshida, S., Wood, B., Kohara, Y., Leroi, A.M., Ueno N.: "A C. elegans TGF-b, DBL-1, regulates polyploidization and body length"EMBO J.. 12. 205-209 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kurata, T., Ueno, N.: "Xenopus Nbx, a novel NK-1 related gene essential for neural crest formation"Dev.Biol.. 21. 1063-1073 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohawara, B., Yamamoto, T., Tada, M., Ueno, N.: "Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis"Development. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Fukuda, K., Yasugi, S.: "Veisatile roles for sonic hedgehog in gut development"J.Gastroenterol.. 37. 239-246

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., Yasugi, S.: "Pre-gut erdoderm of chick embryos is regionalized by 1.5 days of development"Dev Dyn. 223. 33-47

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeda, J., Tabata, H., Fukuda, K., Yasugi, S.: "Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach"Dev.Grwoth & Differ.. 44. 501-508

    • Related Report
      2002 Annual Research Report
  • [Publications] Mito, T., Inoue, Y., Kimura, S., Miyawaki, K., Niwa, N., Shinmyo, Y., Ohuchi, H., Noji, S.: "Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model"Mech.Dev.. 114. 27-35 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki H, Yamaoka T, Ohuchi H, Yasue A, Nohno T, Kawano H, Kato S, Itakuni M, Nagayama M, Noji S: "Identification of cis-elements regulating expression of Fgf10 during limb development"Int J Dev Biol.. 46(7). 963-967 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tao, K., Yoshimoto, Y., Yoshioka, H., Nohno, T., Noji, S., Ohuchi, H.: "FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin"Mech.Dev.. 116. 39-49 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 網蔵令子, 小林悟: "生体の科学"極顆粒の構築とミトコンドリアrRNA. 7

    • Related Report
      2002 Annual Research Report
  • [Publications] Sekimura, T., Noji, S., Ueno, N., Maini, P.K: "Morphogenesis and Pattern Formation in Biological Systems"Springer-Verlag Tokyo(in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohkawara, B., Iemura, S.-I., ten Dijke, p., Ueno, N.: "Action range of BMP is defined by its N-terminal basic amino acid core"Curr.Biol.. 12. 1-20 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., Yasugi, S.: "The pre-gut endoderm of chick embryo is regionalized by 1.5 days of development"Dev.Dyn.. 223. 33-47 (2002)

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  • [Publications] Makabe, K.W., Kawashima, T., Kawashima, S. et al.: "Springer-Verlag, Tokyo"Maternal genetic information stored in fertilized eggs of the ascidian, Halocynthia Roretzi. "Biology of Ascidian" Sawada, H., Yokosawa, H. and Lamberg, C.C.(eds). 13 (2001)

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  • [Publications] Nishikata, T., Wada, M.R., Tanaka, K.J.: "Springer-Verlag, Tokyo"RNA-binding proteins in ascidian development. "Biology of Ascidians" Sawada, H., Yokosawa, H. and Lambert, C.C.(eds). 8 (2001)

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  • [Publications] Tanaka, K.J., Nishikata, T.: "Springer-Verlag, Tokyo"Functional analysis of Ciona intestinalis Y-box protein. "Biology of Ascidians" Sawada, H., Yokosawa, H. and Lambert, C.C.(eds). 7 (2001)

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  • [Publications] Kurata,T. et al.: "Visualization of endogenous BMP signaling during Xenopus development"Differentiation. 67(1). 33-40 (2000)

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  • [Publications] Nishita,M. et al.: "Interaction between Wnt and TGF-beta signalling pathways during formation of Spemannユs organizer"Nature. 403. 781-785 (2000)

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  • [Publications] Sukegawa,A. et al.: "The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodecrmal epithelium."Development. 127. 1971-1980 (2000)

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  • [Publications] Sakamoto,N. et al.: "Role for cGATA-5 in transcriptional regulation of the embryonic chicken pepsino-gen gene by epithelial-mesenchymal interactions in the developing chicken stomach"Developmental Biology. 223. 103-113 (2000)

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  • [Publications] Niwa,N. et al.: "Correlation of diversity of leg morphology in Gryllus bimaculatus (cricket) with divergence in dpp expression pattern during leg development"Development. 127. 4373-4381 (2000)

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  • [Publications] Ishimaru,Y. et al.: "Asymmetric expression of antivin/leftyl in the early chick embryo"Mechanism of Development. 90. 115-118 (2000)

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  • [Publications] 上野直人,野地澄晴: "新・形づくりの分子メカニズム"羊土社. 160 (2000)

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Published: 2001-04-01   Modified: 2018-03-28  

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