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Genomic analysis on genetic factors of human diseases and elucidation of their molecular mechanisms

Research Project

Project/Area Number 12203002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

SUGANO Sumio  The University of Tokyo, Graduate School of Frontier Sciences, PROFESSOR, 大学院新領域創成科学研究科, 教授 (60162848)

Co-Investigator(Kenkyū-buntansha) HATA Akira  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医科学研究院, 教授 (00244541)
MIKI Tetsuro  EHIME UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (00174003)
TOKUNAGA Katsushi  THE UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医学系研究科, 教授 (40163977)
NIIKAWA Norio  NAGASAK UNIVERSITY, GRADUATE SCHOOL OF BIOMEDICAL SCIENCE, PROFESSOR, 大学院医歯薬学総合研究科, 教授 (00111170)
MAEDA Tadakazu  KITAZATO UNIVERSITY, GRADUATE SCHOOL OF SCIENCE, PROFESSOR, 理学部, 教授 (90265728)
成富 研二  琉球大学, 大学院・医学研究科, 教授 (20101446)
三輪 史朗  (財)冲中記念成人病研究所, 理事長(研究職) (40034954)
福嶋 義光  信州大学, 医学部, 教授 (70273084)
林 健志  九州大学, 生体防御医学研究所, 教授 (00019671)
濱口 秀夫  筑波大学, 基礎医学系, 教授 (00091918)
五條堀 孝  国立遺伝学研究所, 遺伝情報解析, 教授 (50162136)
笹月 健彦  国立国際医療センター研究所, 所長(研究職) (50014121)
矢崎 義雄  国立国際医療センター病院, 総長(研究職) (20101090)
Project Period (FY) 2000 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,982,100,000 (Direct Cost: ¥2,982,100,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥856,200,000 (Direct Cost: ¥856,200,000)
Fiscal Year 2003: ¥860,900,000 (Direct Cost: ¥860,900,000)
Fiscal Year 2002: ¥855,900,000 (Direct Cost: ¥855,900,000)
Fiscal Year 2001: ¥406,100,000 (Direct Cost: ¥406,100,000)
KeywordsAllergic asthma / A genome / circulatory organ / high blood pressure / Diabetes / アレルギー / 喘息 / 多因子疾患 / リュウマチ / DNAチップ
Research Abstract

We held an international symposium "The Impact of the Genome Science for the Future Medicine" and a public forum "Genome Science and Society" from January 17^<th> to January 21^<st>, 2006 co-sponsoring with JSPS Research For the Future Program (RFFP: ended at the fiscal year of 2004) and Grant-in-Aid for Scientific Research on Priority Areas "Applied Genomics" (2004-2009). The speakers of the international symposium were 5 from JSPS RFFP, 6 from this program, 3 from "Applied Genomics" and 9 from abroad. For the public forum, Mr Yoichro Murakami gave the Key note speech and there were 6 scientific sessions and panel discussions by the speakers. We got about 550 participants.
We also held a symposium for general public entitled "What does Genome determine and How? : Towards the understanding of the life as a system" in January 18^<th> and 19^<th>, 2006 with the co-sponsor of all 4 of the Grant-in-Aid for Scientific Research on Priority Areas related genome science ( "Integrated Genome", "Medical Genome Science", "Genome Biology", "Genome Informatics"). This symposium consisted of 3 sessions and one panel discussion: Session1: "Genome to Cell" (Chair: Dr. Toshihisa Takagi, with 4 Speakers), Session2: "Genome to Complex Living Functions" (Chair: Dr. Sumio Sugano with 6 Speakers), Session3: "Genome to Human" (Chair: Dr. Naotake Ogasawara with 7 Speakers). The speakers on the panel discussion were Drs Takashi Kadowaki, Naotake Ogasawara, Hideko Urusihara, Asao Fujiyama, Toshihisa Takagi and Kazuto Kato and chaired by Dr. Yuji Kohara. There were about 700 participants. We made final report for our Grant-in-Aid for Scientific Research on Priority Areas Program.

Report

(7 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (75 results)

All 2005 2004 2003 2002 2001 2000 Other

All Journal Article (50 results) Book (1 results) Publications (24 results)

  • [Journal Article] 15'SAGE : 5'-end Serial Analysis of Gene Expression database.2005

    • Author(s)
      Kasai Y, et al.
    • Journal Title

      Nucleic Acids Res. 33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The genome of the social amoeba Dictyostelium discoideum.2005

    • Author(s)
      Eichinger L, et al.
    • Journal Title

      Nature 435

      Pages: 43-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Substitution Rate and Structural Divergence of 5'UTR Evolution : Comparative Analysis Between Human and Cynomolgus Monkey cDNAs.2005

    • Author(s)
      Osada N, et al.
    • Journal Title

      Mol Biol Evol. 22

      Pages: 1976-1982

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] dbQSNF : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.2005

    • Author(s)
      Tahira T, et al.
    • Journal Title

      Hum Mutat. 226

      Pages: 69-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cell surface labeling and mass spectrometry reveal diversity of cell-surface markers and signaling molecules expressed in undifferentiated mouse embryonic stem cells.2005

    • Author(s)
      Nunomura K, et al.
    • Journal Title

      Mol Cell Proteomics. 4

      Pages: 1968-1976

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 5'SAGE : 5'-end Serial Analysis of Gene Expression database.2005

    • Author(s)
      Kasai Y, et al.
    • Journal Title

      Nucleic Acids Res. 33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The genome of the social amoeba Dictyostelium discoideum2005

    • Author(s)
      Eichinger L, et al.
    • Journal Title

      Nature. 435

      Pages: 43-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genome-wide analysis reveals strong correlation between CpG islands with nearby transcription start sites of genes and their tissue specificity.2005

    • Author(s)
      Yamashita R, et al.
    • Journal Title

      Gene. 350

      Pages: 129-136

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] dbQSNP : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.2005

    • Author(s)
      Tahira T., et al.
    • Journal Title

      Hum Mutat. 226

      Pages: 69-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The genome of the social amoeba Dictyostelium discoideum.2005

    • Author(s)
      Eichinger L., et al.
    • Journal Title

      Nature 435

      Pages: 43-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] dbQSNP : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.2005

    • Author(s)
      Tahira T, et al.
    • Journal Title

      Hum Mutat. 226

      Pages: 69-77

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Complete sequencing and characterization of 21,243 full-length human cDNAs.2004

    • Author(s)
      Ota T, et al.
    • Journal Title

      Nat Genet. 36

      Pages: 40-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Full-malaria 2004 : an enlarged database for comparative studies of full-length cDNAs of malaria parasites, Plasmodium species.2004

    • Author(s)
      Watanabe, J., et al.
    • Journal Title

      Nucleic Acids Res. 32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DBTSS, DataBase of Transcriptional Start Sites : progress report 2004.2004

    • Author(s)
      Suzuki, Y., et al.
    • Journal Title

      Nucleic Acids Res. 32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 5'-end SAGE for the analysis of transcriptional start sites.2004

    • Author(s)
      Hashimoto SI., et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1146-1149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs.2004

    • Author(s)
      Oyama M, et al.
    • Journal Title

      Genome Res. 10B

      Pages: 2048-2052

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.2004

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Genome Res. 14

      Pages: 1711-1718

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Promoter prediction analysis on the whole human genome.2004

    • Author(s)
      Bajic VB, et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1467-1473

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 5'-end SAGE for the analysis of transcriptional start sites.2004

    • Author(s)
      Hashimoto SI, et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1146-1149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Complete sequencing and characterization of 21,243 full-length human cDNAs2004

    • Author(s)
      Ota T., et al.
    • Journal Title

      Nat Genet 36

      Pages: 40-45

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D2004

    • Author(s)
      Matsuzaki M., et al.
    • Journal Title

      Nature 428

      Pages: 653-657

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 5'-end SAGE for the analysis of transcriptional start sites2004

    • Author(s)
      Hashimoto SI, et al.
    • Journal Title

      Nat Biotechnol 22

      Pages: 1146-1149

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs2004

    • Author(s)
      Oyama M., et al.
    • Journal Title

      Genome Res 10B

      Pages: 2048-2052

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions2004

    • Author(s)
      Suzuki Y., et al.
    • Journal Title

      Genome Res 14

      Pages: 1711-1718

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Promoter prediction analysis on the whole human genome2004

    • Author(s)
      Bajic VB, et al.
    • Journal Title

      Nat Biotechnol 22

      Pages: 1467-1473

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Construction of a full-length enriched and a 5'-end enriched cDNA library using the oligo-capping method.2003

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Methods Mol Biol. 221

      Pages: 73-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of 5'-end sequences of chimpanzee cDNAs.2003

    • Author(s)
      Sakate R, et al.
    • Journal Title

      Genome Res. 13

      Pages: 1022-1026

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.2003

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Oncogene. 22

      Pages: 3307-3318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level.2003

    • Author(s)
      Shibui-Nihei A et al.
    • Journal Title

      Gene. 311

      Pages: 137-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.2003

    • Author(s)
      Kikuchi S. et al.
    • Journal Title

      Science. 301

      Pages: 376-379

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas : identification of 305 genes differentially expressed between favorable and unfavorable subsets.2003

    • Author(s)
      Ohira M, et al.
    • Journal Title

      Oncogene 22

      Pages: 5525-5536

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Small open reading frames in 5' untranslated regions of mRnas.2003

    • Author(s)
      Yamashita R, et al.
    • Journal Title

      C R Biol. 326

      Pages: 987-991

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level.2003

    • Author(s)
      Shibui-Nihei A, et al.
    • Journal Title

      Gene. 311

      Pages: 137-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas : identification of305 genes differentially expressed between favorable and unfavorable subsets.2003

    • Author(s)
      Ohira M, et al.
    • Journal Title

      Oncogene. 22

      Pages: 5525-5536

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of transcriptomes of human malaria parasite Plasmodium falciparum using full-length enriched library : identification of novel genes and diverse transcription start sites of messenger RNAs.2002

    • Author(s)
      Watanabe J, et al.
    • Journal Title

      Gene. 291

      Pages: 105-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain.2002

    • Author(s)
      Omori Y, et al.
    • Journal Title

      Biochem Biophys Res Commun. 293

      Pages: 470-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs.2002

    • Author(s)
      Osada N, et al.
    • Journal Title

      Genomics. 79

      Pages: 657-662

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DBTSS : DataBase of human Transcriptional Start Sites and full-length cDNAs.2002

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Nucleic Acids Res. 30

      Pages: 328-331

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Transcription Factor Response Element for Gene Expression During Circadian Night.2002

    • Author(s)
      Ueda R.H, et al.
    • Journal Title

      Nature 418

      Pages: 534-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning, mRNA expression and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2).2002

    • Author(s)
      Komatsu T, et al.
    • Journal Title

      DNA Seq. 13

      Pages: 217-220

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Transcription Factor Response Element for Gene Expression During Circadian Night.2002

    • Author(s)
      Ueda R.et al.
    • Journal Title

      Nature. 418

      Pages: 534-539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] HUNT : launch of a full-length cDNA database from the helix research institute.2001

    • Author(s)
      Yudate, H.T., et al.
    • Journal Title

      Nucl. Acid Res. 29

      Pages: 185-188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and characterization of the potential promoter regions of 1031 kinds of human genes.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Genome Res. 11

      Pages: 677-684

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      EMBO Rep. 2

      Pages: 388-393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Construction of full-length-enriched cDNA libraries. The oligo-capping method.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Methods Mol Biol. 175

      Pages: 143-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      EMBO Rep. 2

      Pages: 388-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Statistical analysis of 5' untranslated region of human mRNA using "Oligo-capping" cDNA libraries.2000

    • Author(s)
      Suzuki, Y., et al.
    • Journal Title

      Genomis 64

      Pages: 286-297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative PCR : A Simple and Sensitive Method to Quantify Low-Abundant mRNA Species.2000

    • Author(s)
      Ohmori, Y., et al.
    • Journal Title

      Genomics 67

      Pages: 140-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Statistical analysis of 5' untranslated region of human mRNA using "Oligo-capping" cDNA libraries.2000

    • Author(s)
      Suzuki, Y, et al.
    • Journal Title

      Genomis 64

      Pages: 286-297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative PCR : A Simple and Sensitive Method to Quantify Low-Abundant mRNA Species.2000

    • Author(s)
      Ohmori, Y, et al.
    • Journal Title

      Genomics 67

      Pages: 140-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Methods Mol Biol. (221)2003

    • Author(s)
      Suzuki Y
    • Publisher
      Construction of a full-length enriched and a 5'-end enriched cDNA library using the oligo-cappping method
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Jin Y.: "A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG"EMBO J. 22(4). 905-912 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakate R.: "Analysis of 5'-end sequences of chimpanzee cDNAs"Genome Res.. 13(5). 1022-1026 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuda A.: "Large-scale identification and characterization of human genes that activate NF-kappa B and MAPK signaling pathways"Oncogene. 22(21). 3307-3318 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arai M.: "Gene Expression Profiling Reveals the Mechanism and Pathophysiology of Mouse Liver Regeneration"J.Biol Chem.. 278(32). 29813-29818 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kikuchi S.: "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice"Science. 301. 376-379 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito Y.: "Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4"Cancer Res.. 63. 6651-6657 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watakabe A.: "Similarity and variation in gene expression among human cerebral cortical subregions revealed by DNA macroarrays : technical consideration of RNA expression profiling from postmortem samples"Molecular Brain Research. 88. 74-82 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Katoh T.: "Genetic Isolates in East Asia : A Study of Linkage Disequilibrium in the X chromosome"American Journal of Human Genetics. 71. 395-400 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuroki K.: "Polymorphisms of human CD19 gene : possible association with susceptibility to systemic lupus erythematosus in Japanese"Genes and Immunity. 3(Suppl 1). S21-S30 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hara K.: "Genetic variation in te gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population"Diabetes. 51(2). 536-540 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Himeji D.: "Characterization of caspase-8L : a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade"Blood. 99. 4070-4078 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki Y.: "DBTSS : DataBase of Human Transcriptional Start Sites and full-length cDNAs"Nucleic Acids Res.. 30. 328-331 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hata, A: "Domain-specific mutation of TGF-beta-1 latency-associated peptide cause Camurati-Engelmann disease due to the formation of a constitutively active form of TGF-beta-1"J Biol Chem. 276. 11469-11470 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kimura, A: "A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region"Genomics. 71. 263-270 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto, K: "Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese"Hum Mol Genet. 10(13). 1379-1386 (2001)

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      2001 Annual Research Report
  • [Publications] Sugano, S: "Identification and characterization of the potential promoter regions of 1031 kinds of human genes"Genome Res. 11. 677-684 (2000)

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      2001 Annual Research Report
  • [Publications] Maeda, T: "Preparative two-dimensional gel electrophoresis with agarose gels in the first dimension for high molecular mass proteins"Electrophoresis. 21. 1653-1669 (2000)

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      2001 Annual Research Report
  • [Publications] Mano, H: "Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction"Blood. 98. 422-427 (2001)

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      2001 Annual Research Report
  • [Publications] Kobashi,G: "Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women."Am J Med.Genet. 93. 122-125 (2000)

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      2000 Annual Research Report
  • [Publications] Uemura,K: "Deletion polymorphism of ACE gene is associated with higher blood pressure after hospitalization in normotensive subjects."Hypertens.Res. 23. 201-205 (2000)

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      2000 Annual Research Report
  • [Publications] Yokouchi,Y: "Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families."Genomics.. 66(2). 152-160 (2000)

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      2000 Annual Research Report
  • [Publications] Kinoshita,A: "Domain specific mutations in the human transforming growth factor beta 1 gene (TGFB1) result in Camurati-Engelmann disease."Nature Genet. 26(1). 19-20 (2000)

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      2000 Annual Research Report
  • [Publications] Suzuki,Y: "Statistical analysis of 5' untranslated region of human mRNA using "Oligo-capping" cDNA libraries."Genomics. 64. 286-297 (2000)

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      2000 Annual Research Report
  • [Publications] Shimada,H: "Analysis of genes under the downstream regulation of the t (8;21) fusion protein AML-MTG8 : overexpresion of the TIS11b (ERF-1,cMG1) gene induces myeloid cell proliferation in response to G-CSF."Blood. 96. 655-663 (2000)

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      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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